| Project/Area Number |
21890246
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
TOMI Masatoshi Keio University, 薬学部, 講師 (30334717)
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|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
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| Keywords | 胎盤関門 / トランスポーター / 発現制御 / 胎児栄養環境 / 胎盤 / クレアチン / 妊娠 / エネルギー代謝 / ヌクレオシド / 血液胎盤関門 / 有機アニオン / OAT4 / CNT2 / 分化 |
|---|
| Research Abstract |
The placental barrier regulates fetal transfer of maternal substances and thus maintains fetal environment. Therefore, it is important to elucidate functional regulations at the placental barrier. In this study, we clarified regulations of transporter expression at the placental barrier by (1) differentiation to the placental barrier, (2) gestational diabetes, and (3) caloric restriction. These results represent that the molecular expression at the placental barrier are regulated by placental differentiation and maternal nutrition environment in order to maintain fetal environment.
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