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Correlation between the bone-remodeling and angiogenesis on the diploic vein

Research Project

Project/Area Number 21890249
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKeio University

Principal Investigator

TORIUMI Haruki  Keio University, 医学部, 研究員(非常勤) (30528203)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥1,157,000 (Direct Cost: ¥890,000、Indirect Cost: ¥267,000)
Fiscal Year 2009: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
Keywords板間静脈 / 頭頸部微小循環 / 骨微小循環 / 骨代謝 / 骨リモデリング / 血管新生 / 頭痛 / 脳血管障害 / Diploic veins / 骨内微小循環 / in vivo イメージング / 頭蓋内循環 / 片頭痛 / シェアストレス / 血管内皮 / 微小循環解析 / 骨内循環
Research Abstract

To examine the development of the diploic veins in the calvarium, FITC-dextran was injected into the tail vein. The total area of the diploic veins showed a continuous, age-dependent development. We also measured the red blood cell (RBC) velocities in the diploic veins using an in vivo imaging technique and revealed RBCs with a significantly high velocity and unidirectional characteristics at the entrance route. The route passed from the basal periosteum of the cranial bone via the dura mater and into the diploic veins. Our findings indicate the existence of communications between intra- and extra-cranial circulation.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (17 results)

All 2011 2010 2009

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (6 results)

  • [Journal Article] Developmental and circulatory profile of the diploic veins2011

    • Author(s)
      Toriumi H, Shimizu T, Shibata M, Unekawa M, Tomita Y, Tomita M, Suzuki N
    • Journal Title

      Microvascular Research 81巻

      Pages: 97-102

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Capillary Remodeling and Collateral Growth without Angiogenesis after Unilateral Common Carotid Artery Occlusion in Mice.2011

    • Author(s)
      Tomita M, Tomita Y, Unekawa M, Toriumi H, Suzuki N
    • Journal Title

      Neuroimage 56巻

      Pages: 1001-1010

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Capillary Remodeling and Collateral Growth without Angiogenesis after Unilateral Common Carotid Artery Occlusion in Mice.2011

    • Author(s)
      Guo H, Itoh Y, Toriumi H, Yamada S, Tomita Y, Hoshino H, Suzuki N
    • Journal Title

      Microcirculation 18巻

      Pages: 221-227

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Developmental and circulatory profile of the diploic veins2011

    • Author(s)
      Toriumi H, Shimizu T, Shibata M, Unekawa M, Tomita Y, Tomita M, Suzuki N
    • Journal Title

      Microvascular Research

      Volume: 81 Pages: 97-102

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Capillary Remodeling and Collateral Growth without Angiogenesis after Unilateral Common Carotid Artery Occlusion in Mice.2011

    • Author(s)
      Tomita M, Tomita Y, Unekawa M, Toriumi H, Suzuki N
    • Journal Title

      Neuroimage

      Volume: 56 Pages: 1001-1010

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Capillary Remodeling and Collateral Growth without Angiogenesis after Unilateral Common Carotid Artery Occlusion in Mice.2011

    • Author(s)
      Guo H, Itoh Y, Toriumi H, Yamada S, Tomita Y, Hoshino H, Suzuki N
    • Journal Title

      Microcirculation

      Volume: 18 Pages: 221-227

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resident endothelial cells surrounding damaged arterial endothelium reendothelialize the lesion.2010

    • Author(s)
      Itoh Y, Toriumi H, Yamada S, Hoshino H, Suzuki N
    • Journal Title

      Arterioscler Thromb Vasc Biol. 30巻

      Pages: 1725-1732

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] RBC velocities in single capillaries of mouse and rat brains are the same, despite 10-fold difference in body size.2010

    • Author(s)
      Unekawa M, Tomita M, Tomita Y, Toriumi H, Miyaki K, Suzuki N
    • Journal Title

      Brain Research. 1320巻

      Pages: 69-73

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resident endothelial cells surrounding damaged arterial endothelium reendothelialize the lesion.2010

    • Author(s)
      Itoh Y, Toriumi H, Yamada S, Hoshino H, Suzuki N
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 30 Pages: 1725-1732

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RBC velocities in single capillaries of mouse and rat brains are the same, despite 10-fold difference in body size.2010

    • Author(s)
      Unekawa M, Tomita M, TomitaY, Toriumi H, Miyaki K, Suzuki N
    • Journal Title

      Brain Research.

      Volume: 1320 Pages: 69-73

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dually supplied T-junctions in arteriolo-arteriolar anastomosis in mice : key to local hemodynamic homeostasis in normal and ischemic states?2009

    • Author(s)
      Toriumi Haruki
    • Journal Title

      Stroke 40

      Pages: 3378-3383

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウス中大脳動脈閉塞モデルにおける虚血周辺領域の微小血管およびアストロサイトの経時的形態観察2010

    • Author(s)
      鳥海春樹、正本和人、冨田裕、畝川美悠紀、田桑弘之、伊藤義彰、菅野巌、鈴木則宏
    • Organizer
      第22回日本脳循環代謝学会総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] TRPV1受容体を介した三叉神経の侵害刺激がCSD発生に及ぼす影響2010

    • Author(s)
      鳥海春樹、畝川美悠紀、黒井俊哉、佐藤仁、舟久保恵美、岩下達雄、小泉健三、柴田護、清水利彦、鈴木則宏
    • Organizer
      第38回日本頭痛学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] The circulatory profile of the diploic veins2010

    • Author(s)
      Toriumi H, Unekawa M, TomitaY, Shibata M, Shimizu T,Suzuki N
    • Organizer
      9th World Congress for Microcirculation
    • Place of Presentation
      Paris, France
    • Related Report
      2010 Final Research Report
  • [Presentation] The circulatory profile of the diploic veins2010

    • Author(s)
      Toriumi H, Unekawa M, Tomita Y, Shibata M, Shimizu T, Suzuki N
    • Organizer
      9^<th> World Congress for Microcirculation
    • Place of Presentation
      Paris, France
    • Related Report
      2010 Annual Research Report
  • [Presentation] 板間静脈の発達と週齢に依存した血流動態変化2009

    • Author(s)
      鳥海春樹
    • Organizer
      第37回日本頭痛学会総会
    • Place of Presentation
      宇都宮
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dually supplied T-junctions in arteriolo-arteriolar anastomosis in mice2009

    • Author(s)
      鳥海春樹
    • Organizer
      Brain'09
    • Place of Presentation
      Chicago, US
    • Year and Date
      2009-06-30
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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