Functional analysis of stress-response protein in the mouse brain

• Project/Area Number: 21890263
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Tokyo University of Pharmacy and Life Science
• Principal Investigator: UMEMURA Mariko Tokyo University of Pharmacy and Life Science, 生命科学部, 助教 (30521489)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: 脳 / 転写因子 / ストレス応答 / 脳・神経 / マウス / 脳神経疾患 / モデルマウス

Research Abstract

ATF5 is a stress-response transcription factor. The physiological role of ATF5 was investigated by the generation of ATF5-deficient mice. The ATF5-deficient mice showed abnormal brain morphology and 70% of these mice died within three days of birth. ATF5-knockdown caused an inhibition of neurite outgrowth in migrating neurons of the cerebral cortex. Furthermore, we found that ATF5(-/-) male mice exhibited reduced aggressiveness toward intruders.

Research Products

• [Journal Article] Analysis of membrane topology and identification of essential residues for the yeast endoplasmic reticulum inositol acyltransferase gwt1p (2011)
  • Author(s): Sagane K, Umemura M, Ogawa-Mitsuhashi K, Tsukahara K, Yoko-O T, Jigami Y
  • Journal Title: J Biol Chem. 286 Pages: 14649-14658
  • Peer Reviewed
• [Journal Article] Regulation of the human CHOP gene promoter by the stress response transcription factor ATF5 via the AARE1 site in human hepatoma HepG2 cells (2010)
  • Author(s): Yamazaki T, Ohmi A, Kurumaya H, Kato K, Abe T, Yamamoto H, Nakanishi N, Okuyama R, Umemura M, Kaise T, Watanabe R, Okawa Y, Takahashi S, Takahashi Y
  • Journal Title: Life Sci. 28 Pages: 294-301
  • Peer Reviewed
• [Journal Article] Regulation of the human CHOP gene promoter by the stress response transcription factor ATF5 via the AARE1 site in human hepatoma HepG2 cells (2010)
  • Author(s): Yamazaki T., et al
  • Journal Title: Life Sciences Volume: 87 Pages: 294-301
  • Peer Reviewed
• [Presentation] ATF5 mRNA発現調節機構における翻訳開始点の変動とNMDの寄与 (2011)
  • Author(s): 幡野仁哉,梅村真理子,鈴木実菜子,山崎高志,高橋滋,高橋勇二
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-26
• [Presentation] ATF5 mRNA発現調節機構における翻訳開始点の変動とNMDの寄与 (2011)
  • Author(s): 幡野仁哉, 梅村真理子, 鈴木実菜子, 山崎高志, 高橋滋, 高橋勇二
  • Organizer: 日本農芸化学会 2011年度 大会
  • Place of Presentation: 京都女子大学
  • Year and Date: 2011-03-26
• [Presentation] Nonsense-mediated mRNA decayによるATF5 mRNA発現抑制機構の解明 (2010)
  • Author(s): 梅村真理子,幡野仁哉,山崎高志,高橋滋,高橋勇二
  • Organizer: BMB2010(第33回日本分子生物学会・第83回日本生化学会合同大会)
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] Nonsense-mediated mRNA decayによるATF5 mRNA発現抑制機構の解明 (2010)
  • Author(s): 梅村真理子, 幡野仁哉, 山崎高志, 高橋滋, 高橋勇二
  • Organizer: BMB2010(第33回日本分子生物学会・第83回日本生化学会 合同大会)
  • Place of Presentation: 神戸ポートピアアイランド
  • Year and Date: 2010-12-09
• [Presentation] 軟体動物エストロゲン受容体様タンパク質のNon-genomic functionの解析 (2010)
  • Author(s): 水上薫,雑賀絢,長澤香幸,梶原昌朗,秋山五香,梅村真理子,高橋滋,高橋勇二
  • Organizer: BMB2010(第33回日本分子生物学会・第83回日本生化学会合同大会)
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] 軟体動物エストロゲン受容体様タンパク質のNon-genomic funtionの解析 (2010)
  • Author(s): 水上薫, 雑賀絢, 長澤香幸, 梶原昌朗, 秋山五香, 梅村真理子, 高橋滋, 滴橋勇二
  • Organizer: BMB2010(第33回日本分子生物学会・第83回日本生化学会 合同大会)
  • Place of Presentation: 神戸ポートピアアイランド
  • Year and Date: 2010-12-07
• [Presentation] ATF5 mRNA発現抑制に対するNMDの関与 (2010)
  • Author(s): 幡野仁哉、梅村真理子、山崎高志、高橋滋、高橋勇二
  • Organizer: 日本農芸化学会2010年度大会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-28
• [Presentation] 肺神経内分泌細胞の分化過程におけるShhシグナル経路の関与 (2009)
  • Author(s): 藤井かおり、地田義明、梅村真理子、吉見立也、高橋滋、高橋勇二
  • Organizer: 日本分子生物学会32回年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Remarks] ホームページ等
• [Remarks]
  • URL: http://www.1s.toyaku.ac.jp/Life-Science/lemp-4/