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The modulatory effects on the nucleus accumbens neurons by the activation of dopamine receptors

Research Project

Project/Area Number 21890265
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionTokushima Bunri University (2010)
Nihon University (2009)

Principal Investigator

KOHNOMI Shuntaro  Tokushima Bunri University, 香川薬学部, 助教 (40548947)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
Keywordsオーラルジスキネジア / 側坐核 / ドパミン / 電気生理学 / 中型有棘細胞 / fast-spiking介在細胞
Research Abstract

We investigated the modulatory effects via dopamine receptor on the unitary inhibitory postsynaptic current between two medium spiny neurons, or a medium spiny neuron and a fast-spiking interneuron, using simultaneous electrophysiological recording. We have revealed that these two types of synapse were deferentially modulated via dopamine D_<2,3> receptors.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (3 results)

All 2010 Other

All Presentation (2 results) Remarks (1 results)

  • [Presentation] 側坐核中型有棘細胞間の側方抑制はドパミンD_2受容体の活性化により抑制される2010

    • Author(s)
      鴻海俊太郎
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 側坐核中型有棘細胞間の側方抑制はドパミンD2受容体の活性化により抑制される2010

    • Author(s)
      鴻海俊太郎、越川憲明、小林真之
    • Organizer
      第83回薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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