ADAM22 localization mechanism and myelin formation at the Axon.

• Project/Area Number: 21890269
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General physiology
• Research Institution: Meiji Pharmaceutical University
• Principal Investigator: OGAWA Yasuhiro Meiji Pharmaceutical University, 薬学部, 助教 (00531948)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000); Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000); Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
• Keywords: 遺伝子 / 神経科学 / 脳・神経

Research Abstract

The purpose of this study was to analyze the function of ADAM22 in the neuronal axonal side. We found new interacting molecules with ADAM22, and showed that these molecules associate with ADAM22. Our data suggest that ADAM22 modulate ion-channel activity in neurons.

Research Products

• [Journal Article] ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. (2010)
  • Author(s): Ogawa Y., Oses-Prieto J., Kim M.Y., Horresh I., Peles E., Burlingame A.L., Trimmer J.S., Meijer D., Rasband M.N.
  • Journal Title: Journal of Neuroscience 30 Pages: 1038-1048
  • Peer Reviewed
• [Journal Article] ADAM22, aKv1channel-itneracting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. (2010)
  • Author(s): Ogawa Y, et al.
  • Journal Title: Journal of Neuroscience Volume: 30 Pages: 1038-1048
  • Peer Reviewed
• [Journal Article] ADAM22, aKvlchannel-itneracting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons (2010)
  • Author(s): Ogawa Y, et al.
  • Journal Title: Journal of Neuroscience 30 Pages: 1038-1048
  • Peer Reviewed
• [Journal Article] Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins. (2009)
  • Author(s): Ogawa Y, Rasband MN.
  • Journal Title: Journal of Neuroscience Research 87 Pages: 3502-3510
  • Peer Reviewed
• [Journal Article] Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins. (2009)
  • Author(s): Ogawa Y, et al.
  • Journal Title: Journal of Neuroscience Research Volume: 87 Pages: 3502-3510
  • Peer Reviewed
• [Journal Article] Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins (2009)
  • Author(s): Ogawa Y, et al.
  • Journal Title: Jurnal of Neuroscience Reserach 87 Pages: 3502-3510
  • Peer Reviewed
• [Presentation] Kv1チャネルと結合するADAM22はジャクスタパラノードにMAGUKsタンパク質を局在させる (2010)
  • Author(s): 小川泰弘(代表)
  • Organizer: Neuro2010
  • Place of Presentation: 神戸コンベンションセンター