Involvement of TRPC channels in sympathetically-regulated bone metabolism
| Project/Area Number |
21890276
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
KODAMA Daisuke Aichi Gakuin University, 歯学部, 助教 (40549979)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,392,000 (Direct Cost: ¥1,840,000、Indirect Cost: ¥552,000)
Fiscal Year 2010: ¥1,066,000 (Direct Cost: ¥820,000、Indirect Cost: ¥246,000)
Fiscal Year 2009: ¥1,326,000 (Direct Cost: ¥1,020,000、Indirect Cost: ¥306,000)
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| Keywords | 交感神経 / 骨芽細胞 / イオンチャネル / 交感神経系 / Kチャネル / Gタンパク共役型受容体 |
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| Research Abstract |
By using patch clamp methods, effects of noradrenaline on ion channels were investigated in human osteoblast, SaM-1. The results in this study indicated that noradrenaline inhibited K channels via α1B-adrenergic receptors. The effect was independent of protein kinase C and intracellular Ca^<2+> concentration. This suggested that G_q protein-coupled receptor was not involved in the effect. This study will aid our understanding of the mechanism behind the regulation of bone metabolism by the sympathetic nervous system.
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Report
(3 results)
Research Products
(8 results)
