| Project/Area Number |
21890280
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
MORIMOTO Koji Ritsumeikan University, 立命館グローバル・イノベーション機構, ポストドクトラルフェロー (10543952)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
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| Keywords | 有機化学 / ヘテロ芳香族 / 超原子価ヨウ素 / ビアリール / ヘテロ芳香族化合物 / ヨードニウム塩 / クロスカップリング / ヘテロ芳香族ビアリール類 / Head to Tail / 機能性材料 / 抗腫瘍活性天然物 / 生理活性天然物 |
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| Research Abstract |
Biaryl compounds are versatile building blocks in the synthesis of natural products, pharmaceuticals, agricultural chemicals and π-conjugated organic materials. Therefore, the development of convenient cross-coupling reaction for giving biaryls is one of the important subjects in organic chemistry.
I have developed the biaryl cross-coupling reaction of heteroaromatic compounds via diaryl iodonium salts, leading to various heterobiaryls. In addition, we also developed a metal-free regioselective oxidative synthesis of head-to-tail (H-T) bithiophenes using hypervalent iodine (III) reagent. This unique unsymmetrical coupling reaction was realized through the iodonium intermediate for the switching reactivity of 3-substituted thiophenes, and exclusive nucleophilicity of the neutral 3-substituted thiophenes at the 2-position.
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