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Epigenetics analysis in abnormal behavior through dopamin receptors

Research Project

Project/Area Number 21890281
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionRitsumeikan University

Principal Investigator

INDEN Masatoshi  Ritsumeikan University, 薬学部, 助教 (70512424)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
Keywordsパーキンソン病 / ドパミン神経 / セロトニン神経 / 6-hydroxydopamine / フルオキセチン / L-dopa / リン酸化ヒストンH3 / 線条体
Research Abstract

In this study, we demonstrated that pre-treatment with fluoxetine, an SSRIs, significantly suppressed L-DOPA-induced ERK1/2 and histone H3 phosphorylation, as well as L-DOPA-induced rotational behavior in 6-OHDA-lesioned rats. These data indicate that L-DOPA-derived DA, released as a "false transmitter" from 5-HT terminals, enhances levels of phosphorylated ERK and histone H3, and this results in abnormal behavior. Fluoxetine may attenuate these effects of a false transmitter via 5-HT receptor. In further support of this supposition, these effects of fluoxetine were abolished by pre-treatment with WAY 100135, a 5-HT1A antagonist.
These results suggest that fluoxetine may influence motor function in PD via pharmacological modification of interactions between serotonergic and dopaminergic neuronal networks.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (12 results)

All 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (4 results)

  • [Journal Article] Detoxification of 6-hydroxydopamine induced Parkinsonian neurodegeneration by G-CYPMPO, a novel radical trapper.2011

    • Author(s)
      Kitamura Y, Kamibayashi M, Inden M, Yanagida T, Shibaike T, Takata K, Yasui H, Yamashita M, Taniguchi T
    • Journal Title

      Neurochem Int 58

      Pages: 721-727

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Parkinsonian rotenone mouse model : reevaluation of long-term administration of rotenone in C57BL/6 mice.2011

    • Author(s)
      Inden M, Kitamura Y, Abe M, Tamaki A, Takata K, Taniguchi T
    • Journal Title

      Biol Pharm Bull 34

      Pages: 92-96

    • NAID

      130000402269

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detoxification of 6-hydroxydopamine-induced Parkinsonian neurodegeneration by G-CYPMPO, a novel radical trapper.2011

    • Author(s)
      Kitamura, et al.
    • Journal Title

      Neurochem Int.

      Volume: 58 Pages: 721-727

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parkinsonian rotenone mouse model : reevaluation of long-term administration of rotenone in C57BL/6 mice.2011

    • Author(s)
      Inden, et al.
    • Journal Title

      Biol Pharm Bull.

      Volume: 34 Pages: 92-96

    • NAID

      130000402269

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The 6-hydroxydopamine-induced nigrostriatal neurodegeneration produces microglia-like NG2 glial cells in the rat substantia nigra.2010

    • Author(s)
      Kitamura Y, Inden M, Minamino H, Abe M, Takata K, Taniguchi T
    • Journal Title

      Glia 58

      Pages: 1686-1700

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The 6-hydroxydopamine-induced nigrostriatal neurodegeneration produces microglia-like NG2 glial cells in the rat substantia nigra.2010

    • Author(s)
      Kitamura, et al.
    • Journal Title

      Glia

      Volume: 58 Pages: 1686-1700

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adenosine A2A receptor agonist attenuates HDAC inhibitor-induced cell death through the activation of ERK and Akt in PC12 cells.2009

    • Author(s)
      Inden M, Uozumi A, Tsujiko K, Iwata S, Matsui H, Fujioka H, Murata R, Fujita N
    • Journal Title

      Current Topics in Pharmacology 13

      Pages: 13-23

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adenosine A2A receptor agonist attenuates HDAC inhibitor-induced cell death through the activation of ERK and Akt in PC12 cells2009

    • Author(s)
      Inden, et al.
    • Journal Title

      Current Topics in Pharmacology 13

      Pages: 13-22

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] パーキンソン病モデルラットにおける運動機能へのセロトニン神経関連薬の影響2011

    • Author(s)
      位田雅俊,高田和幸,谷口隆之,北村佳久
    • Organizer
      第34回日本神経科学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2010 Final Research Report
  • [Presentation] パーキンソン病モデルラットにおける運動機能へのセロトニン神経関連薬の影響2011

    • Author(s)
      位田雅俊, 他3名
    • Organizer
      第34回日本神経科学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)(発表確定)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Adenosine A2A receptor agonist protects PC12 cells from histonedeacetylase inhibitor-induced cell death by activating ERK and Akt pathways.2010

    • Author(s)
      魚住暁,位田雅俊,村田理沙,藤岡洋美,藤田典久
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Related Report
      2010 Final Research Report
  • [Presentation] Adenosine A_<2A> receptor agonist protects PC12 cells from histonedeacetylase inhibitor-induced cell death by activating ERK and Akt pathways2010

    • Author(s)
      魚住暁, ら, 他4名
    • Organizer
      第83回 日本薬理学会年会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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