Role of chondroitin sulfate in neuronal plasticity and regeneration
| Project/Area Number |
21890286
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
MIYATA Shinji Kobe Pharmaceutical University, 薬学部, 特別契約研究員 (60533792)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
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| Keywords | コンドロイチン硫酸プロテオグリカン / コンドロイチン硫酸 / プロテオグリカン / 神経可塑性 / 神経再生 / 抑制性神経細胞 / 臨界期可塑性 / 糖鎖生物学 |
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| Research Abstract |
Cortical plasticity is most evident during a critical period in early life, but the mechanisms that restrict plasticity after the critical period are poorly understood. In this study I show that a structural changes of chondroitin sulfate proteoglycans, components of the brain extracellular matrix, leads to the termination of the critical period.
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Report
(3 results)
Research Products
(8 results)
