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Regeneration of transplanted islets

Research Project

Project/Area Number 21890293
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field General medical chemistry
Research InstitutionFukuoka University

Principal Investigator

KODAMA Shohta  Fukuoka University, 医学部, 准教授 (90549338)

Co-Investigator(Renkei-kenkyūsha) NISHINAKAMURA Hitomi  福岡大学, グローバルFUプログラム, 研究員 (90597692)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
Keywords再生 / 幹細胞 / 組織工学 / 膵島細胞 / 膵島移植 / 移植・再生医療 / 再生医学 / 糖尿病 / 発生・分化 / 細胞・組織 / 幹細胞研究
Research Abstract

Pancreatic stem cells were identified as the size restricted cells that were harbored in spleen. In addition, the size restricted small cells retained a homology between pancreas and spleen. Furthermore, the cells that were candidate for pancreatic stem cells were up-regulated the expression of critical genes, including Oct3/4, Sox2, c-Myc, Klf4 and Nanog, which were well-known genes as reprogramming for iPS cells.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] IKKβ Regulates Essential Functions of Vascular Endothelium Through Kinase-Dependent and -Independent Pathways.2011

    • Author(s)
      Ashida N., SenBanerjee S., Kodama S., Foo SY., Coggins M., Spencer J., Zamiri P., Shen D., Li L., Sciuto T., Dvorak A., Gerszten RE., Lin C., Karin M., Rosenzweig A.
    • Journal Title

      Nat Commun 2

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] IKKβ Regulates Essential Functions of Vascular Endothelium Through Kinase-Dependent and -Independent Pathways.2011

    • Author(s)
      Ashida N., SenBanerjee S., Kodama S., Foo SY., Coggins M., Spencer J., Zamiri P., Shen D., Li L., Sciuto T., Dvorak A., Gerszten RE., Lin C., Karin M., Rosenzweig A.
    • Journal Title

      Nat Communications

      Volume: In Press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomics Identifies Multipotency and Low Oncogenic Risk Stem Cells of the Spleen.2010

    • Author(s)
      Dieguez-Acuna F., Kodama S., Okubo Y., Paz AC., Gygi SP., Faustman DL.
    • Journal Title

      Int J Biochem Cell Biol 42

      Pages: 1651-60

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomics Identifies Multipotency and Low Oncogenic Risk Stem Cells of the Spleen.2010

    • Author(s)
      Dieguez-Acuna F., Kodama S., Okubo Y., Paz AC., Gygi SP., Faustman DL.
    • Journal Title

      Int J Biochem Cell Biol

      Volume: 42 Pages: 1651-1660

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomics identifies multipotent and low oncogenic risk stem cells of the spleen2010

    • Author(s)
      Dieguez F., Kodama S, et.al.
    • Journal Title

      The International Journal of Biochemistry & Cell Biology (In Press Online paper available)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Islet Regeneration-Possible Inductions in Adult-2010

    • Author(s)
      Kodama S.
    • Organizer
      The fourth international Conference on Cell Therapy
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2010-11-11
    • Related Report
      2010 Final Research Report
  • [Presentation] Islet Regeneration -Possible Inductions from Adult-2010

    • Author(s)
      Shohta Kodama
    • Organizer
      The fourth international Conference on Cell Therapy
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2010-11-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] A novel approach to prevent early loss of transplanted islets by targeting donor islets with a PPARγ agonist prior to transplantation.2010

    • Author(s)
      Mera T., Kojima D., Itoh T., Matsuoka N., Ono J., Kodama S., Yasunami Y.
    • Organizer
      XXIII International Congress of the Transplantation Society
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2010 Final Research Report
  • [Presentation] Early loss of transplanted islets in the liver mice triggered by HMGB1 is prevented by antithrombin III.2010

    • Author(s)
      Kojima D., Mera T., Itoh T., Matsuoka N., Kodama S., Yasunami Y.
    • Organizer
      XXIII International Congress of the Transplantation Society
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://resweb2.jhk.adm.fukuoka-u.ac.jp/FukuokaUnivHtml/info/5208/R107J.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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