Mechanism of neurotoxicity induced by oseltamivir and NSAIDs under the inflammatory conditions

Research Project

Project/Area Number	21890294
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Applied pharmacology
Research Institution	Fukuoka University
Principal Investigator	AKI Keisei Fukuoka University, 大学病院, 技術職員 (50510179)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000) Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000) Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
Keywords	脳神経疾患 / 血液脳関門 / 中枢毒性 / ジクロフェナクナトリウム / ペリサイト / オセルタミビル
Research Abstract	Oseltamivir and NSAIDs are used in the treatment of influenza. Neurotoxicity such as abnormal behavior and encephalopathy has been reported in influenza patients prescribed their drugs. The purpose of the present study is to examine the blood-brain barrier (BBB) permeability of oseltamivir or NSAIDs under inflammatory conditions. In this study, we demonstrated that (1) novel in vitro BBB models reflecting inflammation were developed, (2) brain pericytes released MMP-9 which may be responsible for BBB dysfuction induced by inflammation, (3) the BBB permeability of dicrofenac sodium salts was not changed under inflammatory conditions.

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