| Project/Area Number |
21890298
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
SHIGEMATSU Yoshiki University of Occupational and Environmental Health, Japan, 医学部, 助教 (10546469)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
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| Keywords | 非小細胞肺癌 / 癌精巣抗原 / 免疫療法 / CTL |
|---|
| Research Abstract |
Method of antibody titer against KK-LC-1 by ELISA using peptide of KK-LC-1 is established. Two patients showed high antibody titer against KK-LC-1 antigen. In these cases, we tried to identify a new epitope in the context of HLA-A2 or HLA-A24 restriction by the Reverse Immunology method, but it was not possible. Therefore, using the lymph node lymphocytes of an autologous patient, the CTL restricted HLA-A2 could be induced by a method of a peptide pulse to dendritic cells, and the new epitope could be identified.
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