Genetic analyses of the roles of neuropeptides expressed in the center of mouse maternal behaviors.
| Project/Area Number |
21890307
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TSUNEOKA Yousuke The Institute of Physical and Chemical Research, 黒田研究ユニット, 研究員 (50549011)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,522,000 (Direct Cost: ¥1,940,000、Indirect Cost: ¥582,000)
Fiscal Year 2010: ¥1,157,000 (Direct Cost: ¥890,000、Indirect Cost: ¥267,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
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| Keywords | 養育行動 / KOマウス / 視床下部 / オキシトシン / バソプレシン / 遺伝子改変マウス / 視床下部内側視索前野 / マウス / Anterior commissural nucleus(ACN) / TRH |
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| Research Abstract |
Oxytocin and vasopressin are considered the neuropeptides which have important roles in regulating mammalian social behaviors, such as maternal behavior. To obtain insight about their function, we created quadruple knockout mice of these genes, and these mice expressed normal maternal behavior. The result of this study suggested that these neuropeptides have different effects on maternal behavior among species and among behavioral contexts, and that they have rather a limited role in the C57BL/6 mouse maternal behavior.
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Report
(3 results)
Research Products
(7 results)
