Searching endophenotype for schizophrenia focusing on schizotypal personality

• Project/Area Number: 21890314
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: HORI Hiroaki 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第三部, 流動研究員 (10554397)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: 統合失調症 / 遺伝子 / 神経科学 / 臨床 / 統合失調症型人格 / 認知機能 / 出生季節 / 神経内分泌 / 視床下部-下垂体-副腎系 / コルチゾール

Research Abstract

We have investigated neurocognition, neuroendocrinological function and season of birth in relation to schizotypal personality and found qualitatively similar abnormalities and tendencies that are well established in schizophrenia, thereby providing evidence suggesting dimensionality between schizotypal personality and schizophrenia.

Research Products

• [Journal Article] Schizotypal personality in healthy adults is related to blunted cortisol responses to the combined dexamethasone/CRH test. (2011)
  • Author(s): Hori H, Teraishi T, Ozeki Y, et al(10名中1番目)
  • Journal Title: Neuropsychobiology 63(4) Pages: 232-241
  • Peer Reviewed
• [Journal Article] Attitudes toward schizophrenia in the general population, psychiatric staff, physicians, and psychiatrists : a web-based survey in Japan. (2011)
  • Author(s): Hori H, Richards M, Kawamoto Y, Kunugi H.
  • Journal Title: Psychiatry Res. 186(2-3) Pages: 183-189
  • Peer Reviewed
• [Journal Article] Possible association of the semaphorin 3D gene (SEMA3D) with schizophrenia. (2011)
  • Author(s): Fujii T, Uchiyama H, Yamamoto N, Hori H, Tatsumi M, Ishikawa M, Arima K, Higuchi T, Kunugi H.
  • Journal Title: J Psychiatr Res. 45(1) Pages: 47-53
  • Peer Reviewed
• [Journal Article] Schizotypal personality in healthy adults is related to blunted cortisol responses to the combined dexamethasone/CRH test. (2011)
  • Author(s): Hiroaki Hori, 他9名
  • Journal Title: Neuropsychobiology Volume: 63 Pages: 232-241
  • Peer Reviewed
• [Journal Article] Attitudes toward schizophrenia in the general population, psychiatric staff, physicians, and psychiatrists : a web-based survey in Japan. (2011)
  • Author(s): Hiroaki Hori, 他3名
  • Journal Title: Psychiatry Research Volume: 186 Pages: 183-189
  • Peer Reviewed
• [Journal Article] Possible association of the semaphorin 3D gene (SEMA3D) with schizophrenia. (2011)
  • Author(s): Takashi Fujii, 他8名
  • Journal Title: Journal of Psychiatric Research Volume: 45 Pages: 47-53
  • Peer Reviewed
• [Journal Article] Difference in Temperament and Character Inventory scores between depressed patients with bipolar II and unipolar major depressive disorders. (2011)
  • Author(s): Daimei Sasayama, 他14名
  • Journal Title: Journal of Affective Disorders Volume: in press
  • Peer Reviewed
• [Journal Article] Poor sleep is associated with exaggerated cortisol response to the combined dexamethasone/CRH test in a non-clinical population. (2011)
  • Author(s): Hiroaki Hori, 他9名
  • Journal Title: Journal of Psychiatric Research Volume: in press
  • Peer Reviewed
• [Journal Article] Relationships between psychological distress, coping styles, and HPA axis reactivity in healthy adults. (2010)
  • Author(s): Hori H, Ozeki Y, Teraishi T, et al(10名中1番目)
  • Journal Title: J Psychiatr Res. 44(14) Pages: 865-873
  • Peer Reviewed
• [Journal Article] Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. (2010)
  • Author(s): Hashimoto R, Hashimoto H, Shintani N, Ohi K, Hori H, et al(14名中5番目)
  • Journal Title: Neurosci Lett. 468(3) Pages: 300-302
  • Peer Reviewed
• [Journal Article] A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls. (2010)
  • Author(s): Hashimoto R, Noguchi H, Hori H, et al(14名中3番目)
  • Journal Title: World J Biol Psychiatry 11(2 Pt 2) Pages: 431-438
  • Peer Reviewed
• [Journal Article] Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression. (2010)
  • Author(s): Kunugi H, Hori H, Adachi N, Numakawa T.
  • Journal Title: Psychiatry Clin Neurosci. 64(5) Pages: 447-459
• [Journal Article] Functional interactions between steroid hormones and neurotrophin BDNF. (2010)
  • Author(s): Numakawa T, Yokomaku D, Richards M, Hori H, Adachi N, Kunugi H.
  • Journal Title: World J Biol Chem. 1(5) Pages: 133-143
  • Peer Reviewed
• [Journal Article] ストレス反応・うつ病とニューロペプチド. (2010)
  • Author(s): 堀弘明、功刀浩
  • Journal Title: HORMONE FRONTIER 17 Pages: 31-37
• [Journal Article] Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression. (2010)
  • Author(s): Hiroshi Kunugi, 他13名
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 64 Pages: 447-459
• [Journal Article] Functional interactions between steroid hormones and neurotrophin BDNF. (2010)
  • Author(s): Tadahiro Numakawa, 他5名
  • Journal Title: World Journal of Biological Chemistry Volume: 1 Pages: 133-143
  • Peer Reviewed
• [Journal Article] The 2nd Schizophrenia International Research Society Conference, 10-14 April 2010, Florence, Italy : Summaries of oral sessions. (2010)
  • Author(s): Moogeh Baharnoori, 他31名
  • Journal Title: Schizophrenia Research Volume: 124
• [Journal Article] ストレス反応・うつ病とニューロペプチド (2010)
  • Author(s): 堀弘明, 他1名
  • Journal Title: HORMONE FRONTIER Volume: 17 Pages: 31-37
• [Journal Article] Possible association between the pituitary adenylate cyclase-activating polypeptide(PACAP)gene and major depressive disorder (2010)
  • Author(s): Ryota Hashimoto, 他13名
  • Journal Title: Neuroscience Letters 468 Pages: 300-302
  • Peer Reviewed
• [Journal Article] A genetic variation in the dysbindin gene(DTNBP1)is associated with memory performance in healthy controls (2010)
  • Author(s): Ryota Hashimoto, 他13名
  • Journal Title: World Journal of Biological Psychiatry 11 Pages: 431-438
  • Peer Reviewed
• [Journal Article] No association between the Bc12-interacting killer(BIK)gene and schizophrenia (2009)
  • Author(s): Kazutaka Ohi, 他11名
  • Journal Title: Neuroscience Letters 463 Pages: 60-63
  • Peer Reviewed
• [Journal Article] The association analysis between the dysbindin gene(DTNBP1)and cognitive functions in Japanese subjects (2009)
  • Author(s): Ryota Hashimoto, 他6名
  • Journal Title: Psychiatry and Clinical Neurosciences 63 Pages: 550-556
  • Peer Reviewed
• [Journal Article] Abnormal microstructures of the basal ganglia in schizophrenia revealed by diffusion tensor imaging (2009)
  • Author(s): Ryota Hashimoto, 他10名
  • Journal Title: World Journal of Biological Psychiatry 10 Pages: 65-69
  • Peer Reviewed
• [Journal Article] Association analysis between schizophrenia and the AP-3 complex genes (2009)
  • Author(s): Ryota Hashimoto, 他14名
  • Journal Title: Neuroscience Research 65 Pages: 113-115
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 堀弘明, 功刀浩
  • Journal Title: 精神疾患とNIRS(中山書店) Pages: 202-211
• [Journal Article] Difference in Temperament and Character Inventory scores between depressed patients with bipolar II and unipolar major depressive disorders.
  • Author(s): Sasayama D, Hori H, Teraishi T, et al(15名中2番目)
  • Journal Title: J Affect Disord. in press
  • Peer Reviewed
• [Journal Article] Poor sleep is associated with exaggerated cortisol response to the combined dexamethasone/CRH test in a non-clinical population.
  • Author(s): Hori H, Teraishi T, Sasayama D, et al(10名中1番目)
  • Journal Title: J Psychiatr Res. in press
  • Peer Reviewed
• [Journal Article] Relationships between psychological distress, coping styles, and HPA axis reactivity in healthy adults
  • Author(s): Riroaki Hori, 他9名
  • Journal Title: Journal of Psychiatric Research (in press)
  • Peer Reviewed
• [Presentation] Schizotypal personality in healthy adults is related to blunted HPA axis reactivity. (2010)
  • Author(s): Hori H, Teraishi T, Ozeki Y, Matsuo J, Kawamoto Y, Kinoshita Y, Suto S, Higuchi T, Kunugi H.
  • Organizer: The 2nd Schizophrenia International Research Society Conference
  • Place of Presentation: Florence
  • Year and Date: 2010-12-04
• [Presentation] Schizotypal personality in healthy adults is related to blunted HPA axis reactivity. (2010)
  • Author(s): Hiroaki Hori, 他8名
  • Organizer: The 2nd Schizophrenia International Research Society Conference
  • Place of Presentation: Firenze Fiera Congress Center(Florence, Italy)
  • Year and Date: 2010-12-04
• [Presentation] 統合失調症における視床下部-下垂体-副腎系機能:低用量デキサメタゾン抑制テストによる検討 (2010)
  • Author(s): 堀弘明、寺石俊也、篠山大明、石川正憲、功刀浩
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 福岡県北九州市、リーガロイヤルホテル小倉
  • Year and Date: 2010-10-09
• [Presentation] 統合失調症における視床下部-下垂体-副腎系機能 : 低用量デキサメタゾン抑制テストによる検討 (2010)
  • Author(s): 堀弘明, 他4名
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: リーガロイヤルホテル小倉(福岡県)
  • Year and Date: 2010-10-09
• [Presentation] Attitudes towards schizophrenia in the general population, psychiatric staff, physicians, and psychiatrists : A web-based survey in Japan. (2009)
  • Author(s): Hori H, Richards M, Kunugi H.
  • Organizer: The 15th Biennial Winter Workshop in Psychoses
  • Place of Presentation: Barcelona
  • Year and Date: 2009-11-17
• [Presentation] Attitudes towards schizophrenia in the general population, psychiatric staff, physicians, and psychiatrists : A web-based survey in Japan (2009)
  • Author(s): 堀弘明, 他2名
  • Organizer: The 15th Biennial Winter Workshop in Psychoses
  • Place of Presentation: Barcelona, Spain(Hotel Fira Palace)
  • Year and Date: 2009-11-17
• [Presentation] 健常者と外来うつ病患者における視床下部-下垂体-副腎系機能:DEX/CRHテストによる検討 (2009)
  • Author(s): 堀弘明, 他5名
  • Organizer: 第31回日本生物学的精神医学会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2009-04-25
• [Presentation] Relationships of psychological distress and sleep status with HPA axis function in a non-clinical population (2009)
  • Author(s): 堀弘明, 他3名
  • Organizer: World Psychiatric Association
  • Place of Presentation: Florence, Italy(Florence Congress Center)
  • Year and Date: 2009-04-02
• [Book] 統合失調症型パーソナリティと半球優位性(精神疾患とNIRS.)(編集:福田正人) (2009)
  • Author(s): 堀弘明、功刀浩
  • Publisher: 中山書店
• [Remarks] 独立行政法人国立精神・神経医療研究センター神経研究所 疾病研究第三部 webページ
  • URL: http://www.ncnp.go.jp/nin/guide/r3/index.html
• [Remarks] 独立行政法入国立精神神経医療研究センター神経研究所疾病研究第三部webページ
  • URL: http://www.ncnp.go.jp/nin/guide/r3/index.html
• [Remarks] 独立行政法人国立精神・神経医療研究センター神経研究所 疾病研究第三部webページ
  • URL: http://www.ncnp.go.jp/nin/guide/r3/index.html