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Search for Proteomics-based analysis of non-alcoholic fatty liver diseases (NAFLD/NASH) in mice.

Research Project

Project/Area Number 21890318
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionNational Institute of Biomedical Innovation

Principal Investigator

NAGANO Kazuya  National Institute of Biomedical Innovation, 創薬基盤研究部バイオ創薬プロジェクト, 研究員 (40548301)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
Keywordsメタボリックシンドローム / Non-alcoholic steatohepatitis(NASH) / Non-alcoholic fatty liver disease(NAFLD) / バイオマーカー / NAFLD / NASH / 抗体プロテオミクス技術
Research Abstract

It has been estimated that non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD), early stage of NASH, become main factors to cause liver cancer and hepatic cirrhosis in future. Therefore, development of diagnostic and therapeutic techniques is urgently needed. However these diseases are hardly known, due to having been recently recognized. In this study, we searched for NAFLD-related proteins and resulted in successfully identifying 8 kinds of candidate proteins more highly expressed in liver of NAFALD model mice.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (7 results)

All 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (3 results)

  • [Journal Article] Limited expression of reticulocalbin-1 in lymphatic endothelial cells in lung tumor but not in normal lung.2011

    • Author(s)
      Yoshida Y., Yamashita T., Nagano K., Imai S., Nabeshi H., Yoshikawa T., Yoshioka Y., Abe Y., Kamada H., Tsutsumi Y., Tsunoda S.
    • Journal Title

      Biochem.Biophys.Res.Commun. 405(4)

      Pages: 610-614

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a novel antibody proteomics system using a phage antibody library for efficient screening of tumor-related biomarker proteins.2011

    • Author(s)
      Imai S., Nagano K., Yoshida Y., Okamura T., Yamashita T., Abe Y., Yoshikawa T., Yoshioka Y., Kamada H., Mukai Y., Nakagawa S., Tsutsumi Y., Tsunoda S.
    • Journal Title

      Biomaterials 32(1)

      Pages: 162-169

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Limited expression of reticulocalbin-1 in lymphatic endothelial cells in lung tumor but not in normal lung.2011

    • Author(s)
      Yoshida Y., Yamashita T., Nagano K., Imai S., Nabeshi H., Yoshikawa T., Yoshioka Y., Abe Y., Kamada H., Tsutsumi Y., Tsunoda S.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 405(4) Pages: 610-614

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a novel antibody proteomics system using a phase antibody library for efficient screening of tumor-related biomarker proteins.2011

    • Author(s)
      Imai S., Nagano K., Yoshida Y., Okamura T., Yamashita T., Abe Y., Yoshikawa T., Yoshioka Y., Kamada H., Mukai Y., Nakagawa S., Tsutsumi Y., Tsunoda S.
    • Journal Title

      Biomaterials

      Volume: 32(1) Pages: 162-169

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Proteomics-based analysis of non-alcoholic fatty liver disease (NAFLD) in mice2010

    • Author(s)
      Watanabe T., Yamashita T., Nagano K., Kanasaki S., Yoshikawa T., Yoshioka Y., Itoh N., Abe Y., Kamada H., Tsutsumi Y., Tsunoda S.
    • Organizer
      HUP02010 World Congress
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] プロテオミクスによる非アルコール性脂肪性肝疾患(NAFLD/NASH)のバイオマーカー探索2010

    • Author(s)
      渡邉貴信、長野一也、山下琢矢、岡村賢孝、金崎聡一郎、阿部康弘、吉川友章、吉岡靖雄、鎌田春彦、伊藤徳夫、小泉桂一、角田慎一、堤康央
    • Organizer
      日本薬学会130年会
    • Place of Presentation
      岡山
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Proteomics-based analysis of non-alcoholic fatty liver disease (NAFLD) in mice.2010

    • Author(s)
      Watanabe T., Yamashita T., Nagano K., Kanasaki S., Yoshikawa T., Yoshioka Y., Itoh N., Abe Y., Kamada H., Tsutsumi Y., Tsunoda S.
    • Organizer
      HUPO2010 World Congress
    • Place of Presentation
      Sydney(Australia)
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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