ヒト疾患バイオマーカーの生体外単一分子検出の為の流体光学プラズモンプラットホーム
| Project/Area Number |
21F20789
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 外国 |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
合田 圭介 東京大学, 理学(系)研究科(研究院), 教授 (70518696)
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| Co-Investigator(Kenkyū-buntansha) |
MARTINEZ PANCORB PABLO 東京大学, 理学(系)研究科(研究院), 外国人特別研究員
MARTINEZ PANCORBO PABLO 東京大学, 理学(系)研究科(研究院), 外国人特別研究員
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| Project Period (FY) |
2021-07-28 – 2023-03-31
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| Project Status |
Declined (Fiscal Year 2022)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2022: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2021: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Wearable sensors / biosensing / Raman spectroscopy / gold nanoparticles / nanomesh / SERS |
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| Outline of Research at the Start |
The aims of research is to develop a novel portable and accurate microfluidic nanophotonic platform to detect molecular fingerprints from cancer-derived molecules and virus-derived proteins present in human fluids such as blood, saliva and sweat. As a result, we will be able to confirm the presence of cancer cells or viruses at low concentrations.
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| Outline of Annual Research Achievements |
I published an perspectives paper in Europhysics Letters. We review the theory of metal-free SERS, including electromagnetic enhancement and chemical enhancement, and introduce promising substrates developed recently, including MXenes, transition metal dichalcogenides, and carbon-based substrates. Moreover, we clarify challenges, provide potential solutions, and discuss unexploited applications. This perspective provides not only a broad and detailed view of metal-free SERS at the current stage, but also a roadmap for its future advancement.
I submitted a paper to Advanced Optical Materials that is currently under review. In this paper we demonstrate a highly scalable, wearable SERS sensor based on an easy-to-fabricate, low-cost, ultrathin, flexible, stretchable, adhesive, and bio-integratable gold nanomesh. It can be fabricated in any shape and worn on virtually any surface for label-free, large-scale, in-situ sensing of diverse analytes from low to high concentrations. To show the practical utility of the wearable SERS sensor, we test the sensor for the detection of sweat biomarkers, drugs of abuse, and microplastics. This wearable SERS sensor represents a significant step toward the generalizability and practicality of wearable sensing technology.
I presented my early results at the EUROPEAN RESEARCH DAYS - European Researchers in Japan: Achievements and Opportunities as an invited speaker and some more generic concepts at the Tokyo Metropolitan High School of Science and Technology under the JSPS Science Dialogue initiative to disseminate science.
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| Research Progress Status |
翌年度、交付申請を辞退するため、記入しない。
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| Strategy for Future Research Activity |
翌年度、交付申請を辞退するため、記入しない。
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Report
(1 results)
Research Products
(2 results)
