| Project/Area Number |
21F21082
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 外国 |
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| Review Section |
Basic Section 46010:Neuroscience-general-related
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
McHugh Thomas 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (50553731)
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| Co-Investigator(Kenkyū-buntansha) |
ZHOU YIJUN 国立研究開発法人理化学研究所, 脳神経科学研究センター, 外国人特別研究員
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| Project Period (FY) |
2021-04-28 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2022: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2021: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | hippocampus / hypothalmus / feeding / learning / context / hunger / memory |
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| Outline of Research at the Start |
The last 20 years has seen a significant increase in the prevalence of obesity and diabetes, especially in children. Homeostatic control of energy balance is vital for the survival of all animals and neurons in the brain which control food intake and energy balance by integrating relevant sensory and hormonal signal have been identified. It has been reported that dysfunction in the hippocampus can alter feeding behavior, here we aim to identify the circuits and mechanisms in the central nervous system responsible for memory guided modulation of feeding behavior.
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| Outline of Annual Research Achievements |
Over the last fiscal year, we have made significant progress in our understanding of the neural circuit from subiculum in hippocampus to arcuate nucleus in hypothalamus. Using a virus combination of CRE recombinase and FLP recombinase, we observed the labelling cells in the subiculum. We have also employed viral-based manipulation methods to investigate the role of this circuit in both feeding and learning components. Meanwhile, the behavior paradigm also confirmed that the internal state of animals (hunger or satiety) could be a context for adaptive behaviors. These findings have important implications for our understanding of neural circuits involved in feeding and learning and may pave the way for targeted therapies for related disorders.
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| Research Progress Status |
令和4年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和4年度が最終年度であるため、記入しない。
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