| Project/Area Number |
21F21733
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 外国 |
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| Review Section |
Basic Section 46010:Neuroscience-general-related
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| Research Institution | Okinawa Institute of Science and Technology Graduate University |
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Principal Investigator |
DeSchutter Erik 沖縄科学技術大学院大学, 計算脳科学ユニット, 教授 (00466319)
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| Co-Investigator(Kenkyū-buntansha) |
DENIZOT AUDREY 沖縄科学技術大学院大学, 計算脳科学ユニット, 外国人特別研究員
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| Project Period (FY) |
2021-07-28 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2022: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2021: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | astrocyte / calcium signals / glia / modeling / reaction diffusion / 3D reconstruction / neuroscience / astrocytes / calcium signaling / interdisciplinary |
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| Outline of Research at the Start |
This research aims at decoding the astrocyte “Calcium code”by answering the following question: what are the geometrical factors that regulate the propagation of calcium signals in astrocytes?
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| Outline of Annual Research Achievements |
The simulation results from my work in FY2022 provided novel insights into the structural determinants that finely tune neuron-astrocyte communication in the brain. This work is of high importance as such investigations cannot be performed in live tissue because of the technical limitations to study biological processes at the nanoscale.
The CellScatter software developed during FY2022 will provide computational scientists with realistic 3D cell reconstructions in open-access to investigate various (patho-)physiological biological conditions. We expect that it will have a big impact on the cell biology and neuroscience communities, paving the way for future experimental and theoretical studies on the structural determinants of biochemical processes in health and disease.
Overall, this work unraveled mechanisms by which the complex intracellular nano-architecture shapes the spatio-temporal properties of biochemical signals in health and disease.
In FY2022, this work has led to the publication of 2 articles in peer-reviewed international journals (DOI: 10.1002/glia.24258 and 10.1007/s12031-022-02006-w). An additional manuscript is under peer review (DOI: 10.1101/2022.02.28.482292) and another is in preparation (Denizot et al., 2023, in prep.). I presented those results at both national and international events: 2 talks (Society for Neuroscience, online, Nov 2022 and the 45th Annual Meeting of the Japan Neuroscience Society, Japan, June 2022) and 1 poster (Federation of European Neuroscience Societies Forum 2022, Paris, France, July 2022).
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| Research Progress Status |
令和4年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和4年度が最終年度であるため、記入しない。
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