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Development of tunable gold nanostructures for novel nanopore devices

Research Project

Project/Area Number 21H01736
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 28010:Nanometer-scale chemistry-related
Research InstitutionHokkaido University

Principal Investigator

Mitomo Hideyuki  北海道大学, 電子科学研究所, 准教授 (50564952)

Co-Investigator(Kenkyū-buntansha) 斎木 敏治  慶應義塾大学, 理工学部(矢上), 教授 (70261196)
矢野 隆章  徳島大学, ポストLEDフォトニクス研究所, 教授 (90600651)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2023: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2022: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2021: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Keywords表面プラズモン共鳴 / 金ナノ粒子 / 可動型ナノ構造 / 分子検出 / 表面プラズモン
Outline of Research at the Start

金属のナノ構造体を利用して分子のラマン散乱を増強する表面増強ラマン散乱が高感度分子検出法として注目を集めている。特に、ナノ構造体の狭いギャップ部位で高い増強効果が得られるため、その狭いギャップ部位にいかに効率的に測定対象物質を導入できるかが重要な課題となっている。本研究では、独自に開発した「ハイドロゲルを利用して金属ナノ構造体のギャップ距離を変える技術」を基板上に形成したナノサイズの微細な孔に組み込む技術の開発に取り組み、新しいセンシングシステムの構築を目指す。

Outline of Final Research Achievements

In this study, we worked on the development of a surface-enhanced Raman scattering (SERS) substrate for highly sensitive detection of biopolymers using the surface plasmon resonance exhibited by gold nanostructures under irradiation with light of a specific wavelength. According to our original technique of "the gap distance control of metal nanostructures using hydrogel", we newly prepared self-assembled films composed of triangular-shaped gold nanoplates and attached them to the thermo-responsive hydrogel. Furthermore, we developed a new approach to introduce analyte molecules into the nanogap structures, resulting in a highly sensitive SERS measurement system that is enough to obtain Raman scattering signals from a single protein molecule.

Academic Significance and Societal Importance of the Research Achievements

金属のナノ構造体は局在表面プラズモン共鳴と呼ばれる特異な光学現象を示す。この局在表面プラズモン共鳴を利用することで、高感度なバイオセンシング基材の開発が可能になる。本研究では、金属ナノ構造体の作製とその構造体の制御技術を構築した。さらに、測定対象物質をナノ構造体に導入する新しい方法も開発した。その結果、タンパク質1分子を同定可能な高感度デバイスの作製に成功した。本技術は、1滴の液体から様々な生体物質の検出を可能し、簡便なヘルスチェックシステムの構築により、人々の健康管理に貢献するものになると期待される。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (31 results)

All 2024 2023 2022 2021 Other

All Journal Article (11 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 11 results,  Open Access: 7 results) Presentation (17 results) (of which Int'l Joint Research: 8 results,  Invited: 6 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Dynamic Orientation Control of Gold Nanorods in Polymer Brushes by Their Thickness Changes for Plasmon Switching2024

    • Author(s)
      Sekizawa Yu、Hasegawa Yuka、Mitomo Hideyuki、Toyokawa Chisato、Yonamine Yusuke、Ijiro Kuniharu
    • Journal Title

      Advanced Materials Interfaces

      Volume: 11 Issue: 11 Pages: 2301066-2301066

    • DOI

      10.1002/admi.202301066

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spatially Uniform and Quantitative Surface-Enhanced Raman Scattering under Modal Ultrastrong Coupling Beyond Nanostructure Homogeneity Limits2024

    • Author(s)
      Suganami Yoshiki、Oshikiri Tomoya、Mitomo Hideyuki、Sasaki Keiji、Liu Yen-En、Shi Xu、Matsuo Yasutaka、Ijiro Kuniharu、Misawa Hiroaki
    • Journal Title

      ACS Nano

      Volume: 18 Issue: 6 Pages: 4993-5002

    • DOI

      10.1021/acsnano.3c10959

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Size Segregation of Gold Nanoparticles into Bilayer-like Vesicular Assembly2023

    • Author(s)
      Wei Jinjian、Yu Yi、Matsuo Yasutaka、Zhang Liang、Mitomo Hideyuki、Chen Yuqin、Ijiro Kuniharu、Zhang Zhide
    • Journal Title

      Langmuir

      Volume: 39 Issue: 49 Pages: 17939-17946

    • DOI

      10.1021/acs.langmuir.3c02628

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] DNA-Functionalized Silver Nanoparticles in an Alcoholic Solvent for Environment-Dictated Multimodal Actuation2022

    • Author(s)
      Kong Li、Wang Luyang、Shi Yali、Peng Lin、Liang Xingguo、Wang Guoqing、Mitomo Hideyuki、Takarada Tohru、Ijiro Kuniharu、Maeda Mizuo
    • Journal Title

      ACS Applied Nano Materials

      Volume: 5 Issue: 8 Pages: 10321-10330

    • DOI

      10.1021/acsanm.2c01493

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Three-dimensional structure determination of gold nanotriangles in solution using X-ray free-electron laser single-particle analysis2022

    • Author(s)
      Nakano Miki、Miyashita Osamu、Joti Yasumasa、Suzuki Akihiro、Mitomo Hideyuki、Niida Yoshiya、Yang Ying、Yumoto Hirokatsu、Koyama Takahisa、Tono Kensuke、Ohashi Haruhiko、Yabashi Makina、Ishikawa Tetsuya、BESSHO YOSHITAKA、Ijiro Kuniharu、Nishino Yoshinori、Tama Florence
    • Journal Title

      Optica

      Volume: 9 Issue: 7 Pages: 776-784

    • DOI

      10.1364/optica.457352

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hysteresis in the Thermo-Responsive Assembly of Hexa(ethylene glycol) Derivative-Modified Gold Nanodiscs as an Effect of Shape2022

    • Author(s)
      Mba Joshua Chidiebere、Mitomo Hideyuki、Yonamine Yusuke、Wang Guoqing、Matsuo Yasutaka、Ijiro Kuniharu
    • Journal Title

      Nanomaterials

      Volume: 12 Issue: 9 Pages: 1421-1421

    • DOI

      10.3390/nano12091421

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Core?Gap?Shell Nanoparticles@Polyaniline with Tunable Plasmonic Chiroptical Activities by pH and Electric Potential Dual Modulation2022

    • Author(s)
      Lin Han、Mitomo Hideyuki、Yonamine Yusuke、Guo Zhiyong、Ijiro Kuniharu
    • Journal Title

      Chemistry of Materials

      Volume: 34 Issue: 9 Pages: 4062-4072

    • DOI

      10.1021/acs.chemmater.2c00313

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Thermo-responsive Silver Nanocube Assembled Films2022

    • Author(s)
      Mitomo Hideyuki、Takeuchi Chie、Sugiyama Ryo、Tamada Kaoru、Ijiro Kuniharu
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: - Issue: 5 Pages: 771-773

    • DOI

      10.1246/bcsj.20220047

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Self-Assembly of Gold Nanorods into a Highly Ordered Sheet via Electrostatic Interactions with Double-Stranded DNA2022

    • Author(s)
      Nakamura Satoshi、Mitomo Hideyuki、Suzuki Shigeaki、Torii Yu、Sekizawa Yu、Yonamine Yusuke、Ijiro Kuniharu
    • Journal Title

      Chemistry Letters

      Volume: - Issue: 5 Pages: 529-532

    • DOI

      10.1246/cl.220069

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vesicle Formation by the Self-Assembly of Gold Nanoparticles Covered with Fluorinated Oligo(ethylene glycol)-Terminated Ligands and Its Stability in Aqueous Solution2021

    • Author(s)
      Wei Jinjian、Huang Xiaoying、Zhang Liang、Chen Yuqin、Niikura Kenichi、Mitomo Hideyuki、Ijiro Kuniharu、Zhang Zhide
    • Journal Title

      Langmuir

      Volume: 37 Issue: 32 Pages: 9694-9700

    • DOI

      10.1021/acs.langmuir.1c00996

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Non-origami DNA for functional nanostructures: From structural control to advanced applications2021

    • Author(s)
      Zhang Lan、Ma Xingyi、Wang Guoqing、Liang Xingguo、Mitomo Hideyuki、Pike Andrew、Houlton Andrew、Ijiro Kuniharu
    • Journal Title

      Nano Today

      Volume: 39 Pages: 101154-101154

    • DOI

      10.1016/j.nantod.2021.101154

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] A New Delivery Technique for Analytes into Narrow Hotspots for Ultra-sensitive SERS at Single-protein Level2024

    • Author(s)
      Tianxu Gao, Hideyuki Mitomo, Xu Shi, Yusuke Yonamine, Kuniharu Ijiro
    • Organizer
      第71回応用物理学会春季学術講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Ultra-sensitive SERS at Single-protein Level via a New Delivery Technique for Analytes into Hotspots2024

    • Author(s)
      Tianxu Gao, Hideyuki Mitomo, Xu Shi, Yusuke Yonamine, Kuniharu Ijiro
    • Organizer
      日本化学会 第104春季年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Nanogap Tunable Gold Nanotriangle Arrays for Sensitive Protein Detection by SERS2023

    • Author(s)
      Tianxu Gao, Hideyuki Mitomo, Xu Shi, Yusuke Yonamine, Kuniharu Ijiro
    • Organizer
      第74回コロイドおよび界面化学討論会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Active Control of Plasmonic Nanoparticles Using Polymers2023

    • Author(s)
      Hideyuki Mitomo
    • Organizer
      IPC2023 (The 13th SPSJ International Polymer Conference)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Flexible Control of Gold Nanorod Arrangements on Polymer Brush Substrates2023

    • Author(s)
      Hideyuki Mitomo
    • Organizer
      APNFO14 (The 14th Asia-Pacific Conference on Near-field Optics)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Fabrication of Tunable Gold Nanoprism Array with Thermo-responsive Hydrogel for a Sensitive Plasmonic Sensor2023

    • Author(s)
      Tianxu Gao, Hideyuki Mitomo, Yusuke Yonamine, Kuniharu Ijiro
    • Organizer
      日本化学会 第103春季年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Flexibly Configurable Gold Nanorod Arrays Templated on Polymer Brush Substrates2023

    • Author(s)
      Hideyuki Mitomo
    • Organizer
      MATCON2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Flexibly Configurable Gold Nanorod Arrays on Polymer Brush Substrates2022

    • Author(s)
      Hideyuki Mitomo
    • Organizer
      2022 RIES-CEFMS Symposium
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Gold Nanorod Arrays with Flexible Structures on Polymer Brush Substrates2022

    • Author(s)
      Hideyuki Mitomo
    • Organizer
      AsiaNANO 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高分子ブラシを利用した棒状金ナノ粒子の垂直配列化と配向変化2022

    • Author(s)
      関澤 祐侑・三友 秀之・与那嶺 雄介・磯野 拓也・田島 健次・佐藤 敏文・居城 邦治
    • Organizer
      第73回コロイドおよび界面化学討論会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Reversible assembly of gold nanorods in a DNA brush substrate in response to temperature2022

    • Author(s)
      Jingyan Yang, Hideyuki Mitomo, Yu Sekizawa, Yusuke Yonamine, Kuniharu Ijiro
    • Organizer
      第73回コロイドおよび界面化学討論会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 2次元平面上で構造を制御可能な金ナノロッドアレイの創製2022

    • Author(s)
      三友 秀之・楊 セイケン・関澤 祐侑・与那嶺 雄介・居城 邦治
    • Organizer
      第71回高分子討論会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Assembly Temperature Tuning of Gold Nanoparticles Coated with Oligo(Ethylene Glycol) Derivatives by Free Volume Control of Surface Ligands2021

    • Author(s)
      H. Mitomo, K. Xiong, Y. Shi, Y. Yonamine, K. Ijiro
    • Organizer
      Pacifichem 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reversible assembly of gold nanorods in response to temperature in a DNA brush2021

    • Author(s)
      Jingyan YANG, Hideyuki MITOMO, Yu SEKIZAWA, Yusuke YONAMINE, and Kuniharu IJIRO
    • Organizer
      Pacifichem 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Active Orientation Changes of Gold Nanorods on Polymer Brush Substrates2021

    • Author(s)
      Hideyuki Mitomo
    • Organizer
      2021 5+2 International Joint Symposium
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アルカンチオールを利用した金ナノ粒子の集合化温度の制御2021

    • Author(s)
      熊坤, 三友 秀之, 与那嶺 雄介, 居城 邦治
    • Organizer
      第72回コロイドおよび界面化学討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 溶媒に応じて可逆的に構造形成が可能な金ナノ粒子中空構造体の創製2021

    • Author(s)
      杉山亮、 三友秀之、与那嶺雄介、居城邦治
    • Organizer
      第70回高分子学会年次大会
    • Related Report
      2021 Annual Research Report
  • [Book] 金属ナノ粒子、微粒子の合成、調製と最新応用技術 第7章 第5節「金ナノ粒子の自己組織化と高感度バイオセンサへの展開」2021

    • Author(s)
      三友秀之
    • Total Pages
      558
    • Publisher
      技術情報協会
    • ISBN
      9784861048623
    • Related Report
      2021 Annual Research Report
  • [Remarks] 研究室HP

    • URL

      https://chem.es.hokudai.ac.jp/

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
  • [Remarks] 研究室HP

    • URL

      https://chem.es.hokudai.ac.jp

    • Related Report
      2021 Annual Research Report

URL: 

Published: 2021-04-28   Modified: 2025-01-30  

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