| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2023: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2022: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2021: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
New methods for the construction of medium-sized carbocycles were developed based on pericyclic reactions. The 8pi-electrocyclic reaction of triene derivatives under basic conditions gave rise to seven-membered carbocycles. The utility of the new method was demonstrated through the concise total synthesis of 6,11-epoxyisodaucane, an essential oil constituent extracted from the Tritomaria polita liverwort.
On the other hand, the Cope rearrangement reaction of a five-membered gem-divinyl compound was developed for obtaining a nine-membered compound. The product was transformed into an analogue of Cristaxenicin A, a natural product having a unique core structure consisting of a nine-membered carbocycle coupled with a substituted dihydropyran.
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