| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2023: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2022: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2021: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Outline of Final Research Achievements |
The ortho- and benzyl-position-selective C(sp3)-H alkylation of aromatic anilinium salts has been successfully developed by utilizing the electrostatic interaction between catalyst and substrate. By using this reaction, valine-selective C(sp3)-H alkylation of dipeptides and tripeptides containing valine(s) was realized. We also found that the C(sp2)-H borylation at the 2-position of indole derivatives is greatly accelerated by utilizing hydrogen bonds between the substrate and the additive. Furthermore, by inclusion of aromatic compounds in cyclodextrin, which is a cyclic compound, we succeeded in developing site-selective C(sp2)-H trifluoromethylation of aromatic compounds.
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