| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2023: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2022: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2021: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Outline of Final Research Achievements |
In this study, we found a simple method to create artificial enzymes by modifying the active center of the cupin protein. In highly selective proteins which was screened using this method, slight movement of the metal center was observed. Although it is a common theory that the metal centers of proteins are spacially fixed, it is becoming clear that they indeed move slightly in position thanks to the improvement of analytical techniques. The observations obtained in this study illustrate that we have succeeded in artificially installing such an important factor in the function of a natural enzyme into a protein.
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