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Learning from the nasal cavity: understanding and using gas flow in complex channels to realise artificial olfaction

Research Project

Project/Area Number 21H01971
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 34020:Analytical chemistry-related
Research InstitutionNational Institute for Materials Science

Principal Investigator

SHIBA Kota  国立研究開発法人物質・材料研究機構, 高分子・バイオ材料研究センター, 主幹研究員 (20638126)

Co-Investigator(Kenkyū-buntansha) 田村 亮  国立研究開発法人物質・材料研究機構, マテリアル基盤研究センター, チームリーダー (20636998)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2023: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2021: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords鼻腔 / 粘性係数 / 分子量 / 流体力学 / 構造力学 / 流体―構造相互作用 / 気体 / 流体 / マイクロ流路 / 機械学習 / 有限要素解析
Outline of Research at the Start

ヒトの五感の中で、人工の「嗅覚」の開発だけが依然道半ばである。その実現がもたらすであろう様々な応用は人類にとって有用であり、この開発は基礎科学から産業に至るまで広い視点で重要な課題である。この課題に対して、本研究では、鼻の内部構造(鼻腔)とそこでのガス流れの相関を詳細に検討することで、人工嗅覚の実現に資するセンサ開発の指針獲得を目指す。申請者がこれまで独自に開発したガス分子量および粘度測定手法によるガス流れのリアルタイム計測に加え、流体シミュレーションと機械学習を組み合わせたガス流れ・センサ応答の最適化プロセスを組み込むことで、目的達成に向けた研究を加速する。

Outline of Final Research Achievements

This study addressed the development of methods and equipment for measuring the complex airflow that occurs inside the nasal cavity. It is important to understand the correlation between the fine and intricate structure of the nasal cavity and the airflow that occurs there as a factor in the perception of odour. As a first step towards this, this study investigated methods to realise airflow measurement in several commercially available nasal cavity models. Further research will be carried out to understand odour perception, nasal structures and airflow in more detail and systematically by using more nasal cavity models in the future.

Academic Significance and Societal Importance of the Research Achievements

ニオイ知覚と鼻腔内構造およびそこで生じる気流との相関について正確に理解することは、例えば嗅覚障害者の治療指針を獲得する上で重要である。すなわち、どのような気流を生じさせる鼻腔内構造があれば、ニオイ知覚が最大化されるといった知見を蓄積することで、これを外科的な手術や治療の方針として利用できるということである。新型コロナウイルスの流行以来、嗅覚障害を訴える人は少なからず存在しており、こうした知見を獲得し速やかに臨床応用していくことには大きな意義があると考えている。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (24 results)

All 2024 2023 2022 2021 Other

All Int'l Joint Research (1 results) Journal Article (17 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 14 results,  Open Access: 7 results) Presentation (2 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] Harvard University/University of Connecticut(米国)

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Tailoring stresses in piezoresistive microcantilevers for enhanced surface stress sensing: insights from topology optimization2024

    • Author(s)
      Zhuang Chao、Minami Kosuke、Shiba Kota、Yoshikawa Genki
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 63 Issue: 1 Pages: 015005-015005

    • DOI

      10.35848/1347-4065/ad1939

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Audible sensing of low-ppm concentration gases2024

    • Author(s)
      Yildirim Tanju、Feng Meng-Qun、Shiba Kota、Minami Kosuke、Yoshikawa Genki
    • Journal Title

      Sensors and Actuators A: Physical

      Volume: 370 Pages: 115215-115215

    • DOI

      10.1016/j.sna.2024.115215

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sorption Kinetic Parameters from Nanomechanical Sensing for Discrimination of 2-Nonenal from Saturated Aldehydes2024

    • Author(s)
      Minami Kosuke、Zhou Yingcheng、Imamura Gaku、Shiba Kota、Yoshikawa Genki
    • Journal Title

      ACS Sensors

      Volume: 9 Issue: 2 Pages: 689-698

    • DOI

      10.1021/acssensors.3c01888

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Automated odor-blending with one-pot Bayesian optimization2024

    • Author(s)
      Fukui Yota、Minami Kosuke、Shiba Kota、Yoshikawa Genki、Tsuda Koji、Tamura Ryo
    • Journal Title

      Digital Discovery

      Volume: - Issue: 5 Pages: 969-976

    • DOI

      10.1039/d3dd00215b

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Precipitative Coating of Calcium Phosphate on Microporous Silica?Titania Hybrid Particles in Simulated Body Fluid2023

    • Author(s)
      Kimura Reo、Shiba Kota、Fujiwara Kanata、Zhou Yanni、Yamada Iori、Tagaya Motohiro
    • Journal Title

      Inorganics

      Volume: 11 Issue: 6 Pages: 235-235

    • DOI

      10.3390/inorganics11060235

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A portable audible-range acoustical approach for determining headspace vapour-phase properties2023

    • Author(s)
      Yildirim Tanju、Feng Meng-Qun、Shiba Kota、Minami Kosuke、Yoshikawa Genki
    • Journal Title

      Sensors and Actuators A: Physical

      Volume: 358 Pages: 114438-114438

    • DOI

      10.1016/j.sna.2023.114438

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pattern Recognition Using Chemical Sensor for Identification of Solid Materials by Responses to Multiple Probe Gases2023

    • Author(s)
      Minami Kosuke、Shiba Kota、Yoshikawa Genki
    • Journal Title

      IEEE Sensors Letters

      Volume: 7 Issue: 9 Pages: 1-4

    • DOI

      10.1109/lsens.2023.3300802

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual domain acoustic olfactory discriminator2023

    • Author(s)
      Yildirim Tanju、Feng Meng-Qun、Ngo Thuc Anh、Shiba Kota、Minami Kosuke、Yoshikawa Genki
    • Journal Title

      Sensors and Actuators A: Physical

      Volume: 350 Pages: 114102-114102

    • DOI

      10.1016/j.sna.2022.114102

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strain Sensor-Inserted Microchannel for Gas Viscosity Measurement2023

    • Author(s)
      Shiba Kota、Liu Linbo、Li Guangming
    • Journal Title

      Biosensors

      Volume: 13 Issue: 1 Pages: 76-76

    • DOI

      10.3390/bios13010076

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Linear Stiffness Tuning in MEMS Devices via Prestress Introduced by TiN Thin Films2023

    • Author(s)
      Zhuang Chao、Minami Kosuke、Shiba Kota、Yoshikawa Genki
    • Journal Title

      ACS Applied Engineering Materials

      Volume: - Issue: 4 Pages: 1213-1219

    • DOI

      10.1021/acsaenm.3c00034

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 嗅覚センサと機械学習によりニオイのデジタル化に挑む2023

    • Author(s)
      田村亮、柴弘太
    • Journal Title

      Think & Act

      Volume: ー Pages: 23-31

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Visualization of Flow‐Induced Strain Using Structural Color in Channel‐Free Polydimethylsiloxane Devices2022

    • Author(s)
      Shiba Kota、Zhuang Chao、Minami Kosuke、Imamura Gaku、Tamura Ryo、Samitsu Sadaki、Idei Takumi、Yoshikawa Genki、Sun Luyi、Weitz David A.
    • Journal Title

      Advanced Science

      Volume: 10 Issue: 1 Pages: 2204310-2204310

    • DOI

      10.1002/advs.202204310

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 構造色で気体を「見る」2022

    • Author(s)
      柴弘太
    • Journal Title

      「低次元系光機能材料研究会」ニュースレター

      Volume: 27 Pages: 10-13

    • Related Report
      2022 Annual Research Report
    • Open Access
  • [Journal Article] Drug Molecular Immobilization and Photofunctionalization of Calcium Phosphates for Exploring Theranostic Functions2022

    • Author(s)
      Yamada Iori、Shiba Kota、Galindo Tania Guadalupe Pe?aflor、Tagaya Motohiro
    • Journal Title

      Molecules

      Volume: 27 Issue: 18 Pages: 5916-5916

    • DOI

      10.3390/molecules27185916

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent Advances in Nanomechanical Membrane-Type Surface Stress Sensors towards Artificial Olfaction2022

    • Author(s)
      Minami Kosuke、Imamura Gaku、Tamura Ryo、Shiba Kota、Yoshikawa Genki
    • Journal Title

      Biosensors

      Volume: 12 Issue: 9 Pages: 762-762

    • DOI

      10.3390/bios12090762

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 気体および液体粘度の単一マイクロ流路測定2022

    • Author(s)
      柴弘太
    • Journal Title

      油空圧技術

      Volume: 61 Pages: 45-54

    • NAID

      40022804878

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Determination of quasi-primary odors by endpoint detection2021

    • Author(s)
      Xu Hanxiao、Kitai Koki、Minami Kosuke、Nakatsu Makito、Yoshikawa Genki、Tsuda Koji、Shiba Kota、Tamura Ryo
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 12070-12070

    • DOI

      10.1038/s41598-021-91210-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 流れ誘起ひずみの構造色による可視化を利用した気体識別デバイス2023

    • Author(s)
      柴弘太, Chao Zhuang, 南皓輔, 今村岳, 田村亮, 佐光貞樹, 出井拓己, 吉川元起, Luyi Sun, David A. Weitz
    • Organizer
      第70回応用物理学会春季学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] マイクロ流路を用いた気体および液体粘度の測定2021

    • Author(s)
      柴弘太, Guangming Li, Emmanuel Virot, 吉川元起, David A. Weitz
    • Organizer
      第82回応用物理学会秋季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Remarks] Experimental soft condensed matter group

    • URL

      https://weitzlab.seas.harvard.edu/kota-shiba

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
  • [Patent(Industrial Property Rights)] 流体センサ、流路及びその製造方法並びに流体センサ製造方法2022

    • Inventor(s)
      柴弘太, 吉川元起, 佐光貞樹
    • Industrial Property Rights Holder
      物質・材料研究機構
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-167263
    • Filing Date
      2022
    • Related Report
      2022 Annual Research Report
  • [Patent(Industrial Property Rights)] 粘度測定法及び装置2022

    • Inventor(s)
      柴弘太, 吉川元起
    • Industrial Property Rights Holder
      物質・材料研究機構
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-077844
    • Filing Date
      2022
    • Related Report
      2022 Annual Research Report
  • [Patent(Industrial Property Rights)] 粘度測定法及び装置2021

    • Inventor(s)
      柴弘太, 吉川元起
    • Industrial Property Rights Holder
      物質・材料研究機構
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
    • Overseas

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Published: 2021-04-28   Modified: 2025-01-30  

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