| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2023: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2022: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2021: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
The aim of this work was to develop new chemical biology tools for elucidating physiological functions of membrane-membrane contact sites in living cells. We successfully developed the following tools: (1) fluorescent probes that enable the visualization of membrane contact dynamics with reversibility, (2) chemogenetic techniques that can control the formation and deformation of membrane contacts, (3) novel genetically encoded fluorescent reporters for phosphatidylinositol 4-phosphate (PI4P).
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