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Development of a system to analyze the intracellular dynamics of TLR4 for the discovery of novel vaccine adjuvants

Research Project

Project/Area Number 21H02080
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 37030:Chemical biology-related
Research InstitutionOsaka University

Principal Investigator

Kabayama Kazuya  大阪大学, 放射線科学基盤機構, 教授 (00399974)

Co-Investigator(Kenkyū-buntansha) 狩野 裕考  東北医科薬科大学, 薬学部, 助教 (40774279)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2023: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2022: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2021: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords自然免疫 / TLR4 / スフィンゴミエリン / スフィンゴ脂質 / リポ多糖 / エンドトキシン / パイロトーシス / ライブセルイメージング / リピドA / サイトカイン解析 / イメージング / フローサイトメトリー / リポポリサッカライド / 生細胞イメージング / 細胞イメージング / 糖脂質 / LPS
Outline of Research at the Start

本研究では、TLR4リガンド構造に応じたTLR4/MD2の細胞内動態の解析と、サイトカイン生成プロモーター活性の高感度検出を組み合わせることで、サイトカイン産生経路の仕分けを厳密に評価するシステムを構築する。この研究により、臨床においても有用な新規アジュバントの探索に、いち早く貢献できると考える。

Outline of Final Research Achievements

In this study, we investigated the cytokine production pathways of TLR4 ligands using live-cell imaging technology, flow cytometry, and promoter activity assays. Our results demonstrated a clear difference between Escherichia coli-derived LPS (EcLPS) and Rhodobacter sphaeroides-derived LPS (RsLPS) in terms of transcription factor activation. Specifically, EcLPS induced a concentration-dependent increase in transcription factor activity, whereas RsLPS did not show such an effect. Additionally, in our search for novel TLR4 ligands, we identified sphingomyelin with a fatty acid chain length of 12 (SM-C12) as a new TLR4 ligand. SM-C12 was found to bind to immune cells and subsequently generate inflammasome-related molecules, ultimately triggering pyroptosis.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は現在論文投稿中であるが、新規のTLRリガンドの発見というところで、学術的意義が高い。また、今回見出された分子であるSM-C12は、通常の哺乳動物細胞には見出されておらず、細菌などに存在する可能性が高い外来性の分子である。どの外来種に多く存在するのか詳細な報告は成されておらず、今後の調査が重要となる。また上記分子が、ヒトにおいて正常時には未発現、疾患に応じて発現するなどの現象が見出されれば、感染症や糖尿病における炎症状態などの治療ターゲットとして、大きな社会的意義を持つと思われる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (50 results)

All 2024 2023 2022 2021

All Journal Article (8 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 8 results,  Open Access: 6 results) Presentation (37 results) (of which Int'l Joint Research: 14 results,  Invited: 3 results) Book (2 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] Synthesis and immunological evaluation of TLR1/2 ligand-conjugated RBDs as self-adjuvanting vaccine candidates against SARS-CoV-22024

    • Author(s)
      Manabe Yoshiyuki、Garate-Reyes Brandon、Ito Keita、Hurtado-Guerrero Ram?n、Kabayama Kazuya、Fukase Koichi
    • Journal Title

      Chemical Communications

      Volume: 60 Issue: 29 Pages: 3946-3949

    • DOI

      10.1039/d4cc00462k

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Paraxylines A-G: Highly oxygenated preurianin-type limonoids with immunomodulatory TLR4 and cytotoxic activities from the stem bark of Dysoxylum parasiticum2024

    • Author(s)
      Naini Al Arofatus、Mayanti Tri、Maharani Rani、Harneti Desi、Nurlelasari、Farabi Kindi、Fajriah Sofa、Hilmayanti Erina、Kabayama Kazuya、Shimoyama Atsushi、Manabe Yoshiyuki、Fukase Koichi、Jungsuttiwong Sirriporn、Prescott Thomas Alexander Kyle、Supratman Unang
    • Journal Title

      Phytochemistry

      Volume: 220 Pages: 114009-114009

    • DOI

      10.1016/j.phytochem.2024.114009

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In Vitro Anti-Inflammatory Study of Limonoids Isolated from Chisocheton Plants2024

    • Author(s)
      Hilmayanti Erina、Huang Xuhao、Salam Supriatno、Nurlelasari、Supratman Unang、Kabayama Kazuya、Fukase Koichi
    • Journal Title

      Current Issues in Molecular Biology

      Volume: 46 Issue: 1 Pages: 909-922

    • DOI

      10.3390/cimb46010058

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Antigen/Adjuvant-Displaying Enveloped Viral Replica as a Self-Adjuvanting Anti-Breast-Cancer Vaccine Candidate2023

    • Author(s)
      Ito Keita、Furukawa Hiroto、Inaba Hiroshi、Ohshima Shino、Kametani Yoshie、Maeki Masatoshi、Tokeshi Manabu、Huang Xuhao、Kabayama Kazuya、Manabe Yoshiyuki、Fukase Koichi、Matsuura Kazunori
    • Journal Title

      Journal of the American Chemical Society

      Volume: 145 Issue: 29 Pages: 15838-15847

    • DOI

      10.1021/jacs.3c02679

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improvement of Antibody Activity by Controlling Its Dynamics Using the Glycan?Lectin Interaction2023

    • Author(s)
      Manabe Yoshiyuki、Iizuka Yuki、Yamamoto Ryuku、Ito Keita、Hatano Kanae、Kabayama Kazuya、Fukase Koichi
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 62 Issue: 30

    • DOI

      10.1002/anie.202304779

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Practical Antibody Recruiting by Metabolic Labeling with Caged Glycans2023

    • Author(s)
      Milawati Hersa、Manabe Yoshiyuki、Matsumoto Takuya、Tsutsui Masato、Ueda Yoshihiro、Miura Ayane、Kabayama Kazuya、Fukase Koichi
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 62 Issue: 25

    • DOI

      10.1002/anie.202303750

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intratumoral administration of astatine-211-labeled gold nanoparticle for alpha therapy2021

    • Author(s)
      Kato Hiroki、Huang Xuhao、Kadonaga Yuichiro、Katayama Daisuke、Ooe Kazuhiro、Shimoyama Atsushi、Kabayama Kazuya、Toyoshima Atsushi、Shinohara Atsushi、Hatazawa Jun、Fukase Koichi
    • Journal Title

      Journal of Nanobiotechnology

      Volume: 19 Issue: 1 Pages: 223-223

    • DOI

      10.1186/s12951-021-00963-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunological Evaluation of Conjugate/Co-Assembly of Peptide Antigen and Adjuvant as Self- adjuvanting Anti-breast Cancer Vaccine Candidates.2021

    • Author(s)
      Ito K., Manabe Y., Aiga T., Chang TC., Kabayama K., Ohshima S., Kametani Y., Furukawa H., Inaba H., Matsuura K., Fukase K.
    • Journal Title

      Peptide Science 2020

      Volume: 2020 Pages: 19-20

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Presentation] Development of novel cancer immunotherapy using antibody recruiting strategy2023

    • Author(s)
      Yoshiyuki Manabe, Hersa Milawati, Julinton Sianturi, Takuya Matsumoto, Kazuya Kabayama, Koichi Fukase
    • Organizer
      International Joint Symposium 2023 on Synthetic Organic Chemistry Awaji Yumebutai International Conference Center, Awaji
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of antibody recruiting strategy for novel cancer immunotherapy2023

    • Author(s)
      Yoshiyuki Manabe, Hersa Milawati, Julinton Sianturi, Takuya Matsumoto, Kazuya Kabayama, Koichi Fukase
    • Organizer
      IKOC-15, RIHGA Gran Kyoto, Kyoto
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Improvement of Antibody Activity by Controlling its Dynamics using Glycan-Lectin Interaction2023

    • Author(s)
      Kazuya Kabayama, Yoshiyuki Manabe, Yuki Iizuka, Ryuku Yamamoto, Keita Ito, Kanae Hatano, Koichi Fukase
    • Organizer
      Society for Glycobiology (SfG) Annual Meeting Big Island, Hawaii
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation and Immunological Evaluation of Nanoparticulate Self-adjuvanting Peptide Vaccines as a Breast Cancer Vaccine Candidates2023

    • Author(s)
      Keita Ito, Yoshiyuki Manabe, Hiroto Furukawa, Hiroshi Inaba, Kazunori Matsuura, Masatoshi Maeki, Manabu Tokeshi, Shino Ohshima, Yoshie Kametani, Kazuya Kabayama, Koichi Fukase
    • Organizer
      13th International Peptide Symposium Brisbane Convention&Exhibition Centre, Brisbane
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vitro Anti-inflammatory Study of Limonoids Isolated from Chisocheton Plants2023

    • Author(s)
      Erina Hilmayanti, Xuhao Huang, Unang Supratman, Kazuya Kabayama, and Koichi Fukase
    • Organizer
      IUPAC - ISCNP31 & ICOB11 2023 Hotel Royal Continental, Napoli
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Strategies for Cancer Therapy by Regulating Intracellular Dynamics of Antibody Drugs2023

    • Author(s)
      Kazuya Kabayama
    • Organizer
      4th NAPOSAKA meeting, Napoli
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] スフィンゴミエリン分子種による炎症と細胞死応答の制御2023

    • Author(s)
      黄栩昊, 樺山一哉, 狩野 裕考, 井ノ口 仁一, 深瀬浩一
    • Organizer
      第46回日本分子生物学会年会、神戸ポートアイランド
    • Related Report
      2023 Annual Research Report
  • [Presentation] スフィンゴミエリン分子種によるインフラマソーム制御機構の解明2023

    • Author(s)
      樺山一哉、黄栩昊、狩野裕考、井ノ口仁一、深瀬浩一
    • Organizer
      第16回セラミド研究会学術集会・第17回スフィンゴテラピィ研究会 合同年会、ホテルアローレ(石川)
    • Related Report
      2023 Annual Research Report
  • [Presentation] 抗体医薬の細胞内動態制御によるがん治療戦略2023

    • Author(s)
      樺山一哉
    • Organizer
      第17回東北糖鎖研究会,桐生市文化会館スカイホール(群馬)
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] スフィンゴミエリン分子種によるTLR4 シグナルと細胞死の制御2023

    • Author(s)
      樺山一哉、黄栩昊、狩野裕考、井ノ口仁一、深瀬浩一
    • Organizer
      第65回 日本脂質生化学会(2023年),KKRホテル熊本(熊本)
    • Related Report
      2023 Annual Research Report
  • [Presentation] セルフアジュバンティング戦略を用いたがんペプチドワクチンの創製2023

    • Author(s)
      伊藤啓太, 真鍋良幸,大島志乃,亀谷美恵,古川寛人, 稲葉央, 松浦和則, 真栄城正寿,渡慶次学,樺山一哉,深瀬浩一
    • Organizer
      日本ケミカルバイオロジー学会 第17回年会、大阪大学 豊中キャンパス
    • Related Report
      2023 Annual Research Report
  • [Presentation] α線放出核種 211At を用いたがん特異的な免疫活性化機構の解明2023

    • Author(s)
      黛功樹、樺山一哉、黄栩昊、兼田加珠子、豊嶋厚史、深瀬浩一
    • Organizer
      第14回光塾
    • Related Report
      2022 Annual Research Report
  • [Presentation] α線放出核種を用いた放射線療法における腫瘍特異的な免疫活性化メカニズムの解明2022

    • Author(s)
      黛功樹、樺山一哉、黄栩昊、兼田加珠子、豊嶋厚史、深瀬浩一
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 短寿命α線放出核種を用いた腫瘍特異的な免疫活性化機構の解明2022

    • Author(s)
      黛功樹、樺山一哉、黄栩昊、兼田加珠子、豊嶋厚史、深瀬浩一
    • Organizer
      第27回日本エンドトキシン・自然免疫研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Development of 211At-labeled antibodies and investigation of their endocytosis and inhibition of tumor growth2021

    • Author(s)
      Kazuya Kabayama; Kazuko Kaneda; Yoshiyuki Manabe; Atsushi Shimoyama; Atsushi Toyoshima; Atsushi Shinohara; Koichi Fukase
    • Organizer
      Pacifichem 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Immunological evaluation of co-assembly of lipidated CH401 peptide antigen and lipophilic adjuvant as self-adjuvanting anti- breast cancer vaccine candidates2021

    • Author(s)
      Keita Ito, Yoshiyuki Manabe; Taku Aiga; Kazuya Kabayama; Shino Ohshima; Yoshie Kametani; Hiroto Furukawa; Hiroshi Inaba; Kazunori Matsuura; Koichi Fukase
    • Organizer
      Pacifichem 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitative analysis of galectin-dependent glycoprotein dynamics by using synthetic glycan displaying system on the cell surface2021

    • Author(s)
      Ayane Miura; Syuto Miyake; Kazuya Kabayama; Yoshiyuki Manabe; Asuka Shirakawa; Hiroki Syomura; Toshiyuki Yamaji; Kenichi Suzuki; Koichi Fukase
    • Organizer
      Pacifichem 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cancer immune therapy by antibody- recruiting using metabolic labeling2021

    • Author(s)
      Hersa Milawati, Yoshiyuki Manabe, Kazuya Kabayama, Koichi Fukase
    • Organizer
      16th Meeting of the International Endotoxin and Innate Immunity Society (IEIIS-16)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Immunological Evaluation of Co- Assembling Vaccine of Lipidated-Peptide Antigens and Lipophilic Adjuvants for the Breast Cancer therapy2021

    • Author(s)
      Keita Ito, Yoshiyuki Manabe, Taku Aiga, Kazuya Kabayama, Shino Ohshima, Yoshie Kametani, Hiroto Furukawa, Hiroshi Inaba,Kazunori Matsuura, Koichi Fukase
    • Organizer
      16th Meeting of the International Endotoxin and Innate Immunity Society (IEIIS-16)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development and evaluation of α-ray nuclide labeled antibodies2021

    • Author(s)
      Mayu Higashi, Kazuya Kabayama, Yuichiro Kadonaga, Kohtaro Goto, Wataru Tsukimura, Akio Matsuda, Mamoru Mizuno, Koichi Fukase
    • Organizer
      16th Meeting of the International Endotoxin and Innate Immunity Society (IEIIS-16)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional Analysis of TLR4 Ligands by Fluorescent Imaging and Reporter Assay2021

    • Author(s)
      Hitoshi Ogaki, Kazuya Kabayama, Hikari Naito, Atsushi Shimoyama, Hirotaka Kanoh, Jin-ichi Inokuchi, Koichi Fukase
    • Organizer
      16th Meeting of the International Endotoxin and Innate Immunity Society (IEIIS-16)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development and application of antibodies labeled with alpha-emitting radionuclides2021

    • Author(s)
      Koki Mayusumi, Kazuya Kabayama, Changhao Dai, Kazuko Kaneda, Kazuhiro Ooe, Takahiro Teramoto, Atsushi Toyoshima, Atsushi Shinohara, Koichi Fukase
    • Organizer
      16th Meeting of the International Endotoxin and Innate Immunity Society (IEIIS-16)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 万能治療を目指した短寿命アルファ線核医学治療薬の開発2021

    • Author(s)
      兼田(中島)加珠子, 真鍋 良幸, 下山 敦史, 樺山 一哉, 金井 好克, 豊嶋 厚史, 深瀬 浩一, 篠原 厚
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] アスタチン-211標識金ナノ粒子局所投与による癌増殖抑制2021

    • Author(s)
      片山大輔、加藤弘樹、大江一弘、角永悠一郎、黄栩昊、下山敦史、樺山一哉、深瀬浩一、畑澤順
    • Organizer
      第61回日本核医学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 局所投与による癌増殖抑制のためのアスタチン標識金ナノ粒子の最適化2021

    • Author(s)
      加藤弘樹、片山大輔、大江一弘、角永悠一郎、黄栩昊、下山敦史、樺山一哉、深瀬浩一、畑澤順
    • Organizer
      第61回日本核医学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 新規アルファ線ブラキセラピー開発に向けたAt-211標識金ナノ粒子の合成と機能評価2021

    • Author(s)
      黄栩昊、加藤弘樹、角永悠一郎、下山敦史、樺山一哉、片山大輔、大江一弘、豊嶋厚史、羽場宏光、王洋、篠原厚、深瀬浩一
    • Organizer
      第65回放射化学討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 核医学治療法を目指したAt-211標識機能化金ナノ粒子創製と評価2021

    • Author(s)
      黄栩昊、加藤弘樹、角永悠一郎、下山敦史、樺山一哉、大江一弘、豊嶋厚史、篠原厚、深瀬浩一
    • Organizer
      第15回バイオ関連化学シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] α線核種を標識したがんターゲッティング分子の創製とがん免疫療法への展開2021

    • Author(s)
      黛功樹、 樺山一哉、 戴長浩、 兼田加珠子、 大江一弘、 寺本高啓、 豊嶋厚史、 篠原厚、 深瀬浩一
    • Organizer
      第44回 日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 膜貫通ペプチドを用いたインスリン受容体とガングリオシドGM3の相互作用解析2021

    • Author(s)
      二村友香、樺山一哉、朝比奈雄也、花島慎弥、北條裕信、深瀬浩一
    • Organizer
      第44回 日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] α線核種標識抗体の創製と機能評価2021

    • Author(s)
      東茉由,樺山一哉,角永悠一郎,後藤浩太朗,月村亘,松田昭生,水野真盛,深瀬浩一
    • Organizer
      第44回 日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] TLR4リガンドの機能評価 ~レポーターアッセイとイメージングによる解析~2021

    • Author(s)
      大垣 仁之、 樺山 一哉、 内藤 ひかり、 下山 敦史、 狩野 裕考、 井ノ口 仁一、 深瀬 浩一
    • Organizer
      第44回 日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 難治性がん治療のためのα線核種標識抗体の創製および機能評価2021

    • Author(s)
      樺山一哉
    • Organizer
      東海大学総合医学研究所/マイクロ・ナノ研究開発センター 第17回 研修会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] LacCer-BODIPYを用いた細胞膜脂質のライブセルイメージング解析2021

    • Author(s)
      樺山一哉
    • Organizer
      第15回 スフィンゴテラピィ研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 蛍光標識化糖脂質プローブを用いた細胞膜糖脂質の動態解析2021

    • Author(s)
      樺山一哉、新井健太、蟹江治、蟹江善美、深瀬浩一
    • Organizer
      第40回 日本糖質学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 生細胞表層への合成糖鎖の導入および糖鎖-レクチン相互作用の分子化学的解析2021

    • Author(s)
      三浦彩音、樺山一哉、真鍋良幸、三宅秀斗、白川明日香、初村洋紀、 山地俊之、鈴木健一、深瀬浩一
    • Organizer
      第40回 日本糖質学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] コアフコース含有N-グリカンの機能解明・制御を目指したケミカルバイオロジー研究2021

    • Author(s)
      真鍋良幸,Roberta Marchetti,武部智之,笠原里実,高倉陽平,二瓶渉,田中克典,樺山一哉,Alba Silipo,Antonio Molinaro,深瀬浩 一
    • Organizer
      第15回バイオ関連化学シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] 蛍光標識化糖脂質プローブを用いた細胞膜糖脂質の動態解析2021

    • Author(s)
      樺山一哉、新井健太、蟹江治、蟹江善美、深瀬浩一
    • Organizer
      第63回 日本脂質生化学会
    • Related Report
      2021 Annual Research Report
  • [Book] Glycolipids: Methods and Protocols (Methods in Molecular Biology, 2613)2023

    • Author(s)
      Kazuya Kabayama, Jinichi Inokuchi
    • Total Pages
      314
    • Publisher
      Humana
    • ISBN
      1071629093
    • Related Report
      2022 Annual Research Report
  • [Book] 図説 表面分析ハンドブック(日本表面真空学会) 「光学顕微鏡」2021

    • Author(s)
      手老龍吾,樺山一哉
    • Total Pages
      576
    • Publisher
      朝倉書店
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 金ナノ粒子含有医薬2021

    • Inventor(s)
      加藤弘樹, 深瀬浩一, 樺山一哉ほか
    • Industrial Property Rights Holder
      加藤弘樹, 深瀬浩一, 樺山一哉ほか
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 金ナノ粒子含有医薬2021

    • Inventor(s)
      加藤弘樹, 深瀬浩一, 樺山一哉ほか
    • Industrial Property Rights Holder
      加藤弘樹, 深瀬浩一, 樺山一哉ほか
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] α線放出抗体薬物複合体2021

    • Inventor(s)
      樺山 一哉, 深瀬 浩 一, 角永 悠一郎ほか
    • Industrial Property Rights Holder
      樺山 一哉, 深瀬 浩 一, 角永 悠一郎ほか
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report

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Published: 2021-04-28   Modified: 2025-01-30  

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