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Evolution of STOP1 system for management of multiple stress tolerance

Research Project

Project/Area Number 21H02088
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 38010:Plant nutrition and soil science-related
Research InstitutionGifu University

Principal Investigator

KOYAMA Hiroyuki  岐阜大学, 応用生物科学部, 教授 (90234921)

Co-Investigator(Kenkyū-buntansha) 井内 聖  国立研究開発法人理化学研究所, バイオリソース研究センター, 専任研究員 (90312256)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2023: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2022: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2021: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
KeywordsSTOP1 / 環境耐性 / SAUR / 窒素吸収 / 低酸素耐性 / アルミニウム耐性 / 転写制御 / 進化 / 酸耐性 / シロイヌナズナ / STOP1転写因子 / 多面発現
Outline of Research at the Start

申請者は,自らが発見したSTOP1転写因子が,細胞内pHの転写調節を中軸として,酸性土壌耐性のみならず, 冠水・乾燥耐性も制御することを突き止めた。この提案では,異なる進化を遂げた植物を材料とする情報生物学・逆遺伝学(比較ゲノムと組み合わせる)によりSTOP1システム制御機構の違いを分子レベルで特定し,「合成生物学育種(遺伝子数十を組換えるもの)」で,作物の環境耐性を飛躍的に向上させる基盤を確立する。

Outline of Final Research Achievements

Higher plants adapt to various environmental stresses by resistant mechanisms, while those are often antagonistic. For example, STOP1 transcription factor, which was originally discovered in Arabidopsis, positively regulates tolerance to cellular acidification, and uses this mechanism to positively regulate submergence tolerance which induce cellular acidification. On the other hand, salt tolerance is positively controlled by STOP1, but drought tolerance is negatively and antagonistically controlled by STOP1. Salt accumulation in soil may be more likely to occur in dry areas, and this is an example of conflicting stress tolerances controlled by the same molecule. In this study, we revealed that crosstalk between regulatory proteins and/or transcription factors, which form gene family, with STOP1contributes to alleviate negative antagonistic effect of STOP1 in stress tolerance.

Academic Significance and Societal Importance of the Research Achievements

植物の環境耐性の分子機構を理解することは、持続可能な食料システムを実現するために重要です。この研究では、陸上植物の環境ストレス耐性を制御する遺伝子であるSTOP1が、どのようにして異なるストレス耐性を制御するか、コケやモデル植物を用いて調べました。複雑な制御機構が、調節タンパク質や転写因子などのほかのタンパク質との相互作用で行われていることと、それが植物により多様であることを明らかにしました。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (7 results)

All 2023 2022 2021 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (2 results)

  • [Int'l Joint Research] University of Saskatchewan(カナダ)

    • Related Report
      2023 Annual Research Report
  • [Journal Article] The transcription factors, STOP1 and TCP20, are required for root system architecture alterations in response to nitrate deficiency2023

    • Author(s)
      Tokizawa Mutsutomo、Enomoto Takuo、Chandnani Rahul、Mora-Mac?as Javier、Burbridge Connor、Armenta-Medina Alma、Kobayashi Yuriko、Yamamoto Yoshiharu Y.、Koyama Hiroyuki、Kochian Leon V.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 120 Issue: 35

    • DOI

      10.1073/pnas.2300446120

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] How do plants remember drought?2022

    • Author(s)
      Sadhukhan Ayan、Prasad Shiva Sai、Mitra Jayeeta、Siddiqui Nadeem、Sahoo Lingaraj、Kobayashi Yuriko、Koyama Hiroyuki
    • Journal Title

      Planta

      Volume: 256 Issue: 1

    • DOI

      10.1007/s00425-022-03924-0

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expression GWAS of PGIP1 Identifies STOP1-Dependent and STOP1-Independent Regulation of PGIP1 in Aluminum Stress Signaling in Arabidopsis2021

    • Author(s)
      Agrahari Raj Kishan、Enomoto Takuo、Ito Hiroki、Nakano Yuki、Yanase Emiko、Watanabe Toshihiro、Sadhukhan Ayan、Iuchi Satoshi、Kobayashi Masatomo、Panda Sanjib Kumar、Yamamoto Yoshiharu Y.、Koyama Hiroyuki、Kobayashi Yuriko
    • Journal Title

      Frontiers in Plant Science

      Volume: 12 Pages: 774687-774687

    • DOI

      10.3389/fpls.2021.774687

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] STOP1 regulatory system: Centered on multiple stress tolerance and cellular nutrient management2021

    • Author(s)
      Koyama Hiroyuki、Wu Liujie、Agrahari Raj Kishan、Kobayashi Yuriko
    • Journal Title

      Molecular Plant

      Volume: 14 Issue: 10 Pages: 1615-1617

    • DOI

      10.1016/j.molp.2021.08.014

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ゼニゴケMpSTOP1 KO株を用いたAl耐性関連遺伝子の解析2022

    • Author(s)
      宮地 右, 渡邉 ひかり, 阿相 幸恵, 井内 聖, 小林 正智, 小林 佑理子, 小山 博之
    • Organizer
      日本土壌肥料学会中部支部
    • Related Report
      2022 Annual Research Report
  • [Presentation] Al 耐性遺伝子PGIP1 の発現量ゲノムワイド関連解析によるPGIP1 発現を制御するシグナル伝達経路と遺伝子の同定2022

    • Author(s)
      Raj Kishan Agrahari, 榎本 拓央, 伊藤 弘樹, 中野 友貴, 柳瀬 笑子, 渡部 敏裕, 井内 聖, 小林 正智, 山本 義治, 小山 博之, 小林 佑理子
    • Organizer
      日本土壌肥料学会
    • Related Report
      2022 Annual Research Report

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Published: 2021-04-28   Modified: 2025-01-30  

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