• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of the host MAPK pathways in plant-virus interactions

Research Project

Project/Area Number 21H02198
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 39040:Plant protection science-related
Research InstitutionOkayama University

Principal Investigator

Hyodo Kiwamu  岡山大学, 資源植物科学研究所, 准教授 (80757881)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2023: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2022: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2021: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords植物RNAウイルス / ゲノムRNA複製 / MAPK / 植物ウイルス / MAPキナーゼ / 抗ウイルス免疫 / 宿主因子
Outline of Research at the Start

これまでに行われた国内外の様々なグループの研究から、植物の抗細菌/糸状菌免疫シグナルにおける mitogen-activated protein kinase (MAPK) 経路の重要性は確立しつつある。一方で、重要な植物病原の一つであるウイルス感染の場におけるMAPK経路の役割には未解明な点が多い。当研究は、(1) MAPK経路を介した植物-ウイルス間の分子攻防および (2) MAPK経路を標的とした植物ウイルス増殖機構、の2点に焦点を当て、MAPKカスケードを巡る植物-ウイルス間相互作用の解明を目指す。

Outline of Final Research Achievements

Plant viruses are significant phytopathogens that cause substantial crop losses worldwide. Due to their limited number of encoded proteins, plant viruses need to exploit the host cell machinery to support their functions, ultimately creating a cellular environment favorable to infection. To achieve this, plant viruses co-opt a range of host-derived factors, known as proviral host factors, to establish infection. These viruses remodel the functions of these proviral host factors to facilitate every step of their life cycle. Understanding the global landscape of plant-virus interactions at the molecular level enhances our knowledge of the viral infection process and may aid in developing novel antiviral strategies. This study aims to investigate the role of the host MAPK pathways in plant-virus interactions.

Academic Significance and Societal Importance of the Research Achievements

植物ウイルスが感染に利用する宿主因子の同定・機能解析はウイルス感染の分子メカニズム解明に必須であり、ひいては、ウイルス感染に対する新規防除法開発に向けた分子基盤整備に貢献する。本研究では、植物の抗細菌/糸状菌免疫において重要なMAPK経路の一部が、red clover necrotic mosaic virusを含むいくつかの植物ウイルス増殖をむしろ促進することを見出した。本知見は、植物-ウイルス間相互作用におけるMAPK経路の新たな役割を示唆する。今後、ウイルスがどのようにして植物MAPK経路を利用しウイルス増殖を促進するのか、その分子メカニズムの詳細を明らかにする必要がある。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (12 results)

All 2024 2023 2022 2021 Other

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (7 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results) Remarks (1 results)

  • [Journal Article] Discovery and Genome Characterization of a Closterovirus from Wheat Plants with Yellowing Leaf Symptoms in Japan2023

    • Author(s)
      Kondo H、Sugahara H、Fujita M、Hyodo K、Andika IB、Hisano H、Suzuki N.
    • Journal Title

      Pathogens

      Volume: 12 Issue: 3 Pages: 358-358

    • DOI

      10.3390/pathogens12030358

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of a novel quinvirus in family Betaflexiviridae that infects winter wheat2022

    • Author(s)
      Kondo, H., Yoshida, N., Fujita, M., Maruyama, K., Hyodo, K., Hiasno, H., Tamada, T., Andika, I.B. and Suzuki, N.
    • Journal Title

      Frontiers in Microbiology

      Volume: 12 Pages: 715545-715545

    • DOI

      10.3389/fmicb.2021.715545

    • NAID

      120007147386

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification and characterization of host factors involved in plant RNA virus replication2021

    • Author(s)
      Hyodo K
    • Journal Title

      J Gen Plant Pathol

      Volume: 87 Issue: 6 Pages: 415-417

    • DOI

      10.1007/s10327-021-01022-9

    • NAID

      130008088746

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 植物RNAウイルスの複製に関わる宿主因子の研究2021

    • Author(s)
      兵頭 究
    • Journal Title

      日本植物病理学会報

      Volume: 87 Pages: 131-131

    • NAID

      130008088746

    • Related Report
      2021 Annual Research Report
  • [Presentation] 黄葉症状を呈するコムギから見出されたクロステロウイルス2024

    • Author(s)
      近藤 秀樹、兵頭 究、鈴木 信弘
    • Organizer
      令和6年度日本植物病理学会大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Autophagy promotes the replication of red clover necrotic mosaic virus2023

    • Author(s)
      Hyodo K, Sudo K, Kondo H, Suzuki N
    • Organizer
      42nd Annual Meeting American Society for Virology
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Replication of single partitiviruses in hosts across three kingdoms; Fungi, Plantae and Animalia2023

    • Author(s)
      Telengech P, Hyodo K, Ichikawa H, Suzuki N
    • Organizer
      42nd Annual Meeting American Society for Virology
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A virus infection modulates plant immunity against bacterial and fungal pathogens2022

    • Author(s)
      Kiwamu Hyodo
    • Organizer
      12th Japan-US Seminar in Plant Pathology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 宿主液胞型H+-ATPaseのハイジャックによる2022

    • Author(s)
      兵頭 究・首藤 丘宇・近藤 秀樹・鈴木 信弘
    • Organizer
      令和4年度日本植物病理学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] A plant virus infection affects secondary bacterial/fungal infections through plant innate immunity2021

    • Author(s)
      Kiwamu Hyodo
    • Organizer
      第68回日本ウイルス学会・Neo Virology Symposium
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 宿主因子から見るウイルスと植物の相互作用2021

    • Author(s)
      兵頭 究
    • Organizer
      第52回岡山植物病理セミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Remarks] 岡山大学(大学院環境生命科学研究科)資源植物科学研究所 植物・微生物相互作用グループ ホームページ

    • URL

      https://www.rib.okayama-u.ac.jp/pmi/index-j.html

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report 2021 Annual Research Report

URL: 

Published: 2021-04-28   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi