| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2023: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2022: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2021: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
To understand the mechanisms underlying centromeric chromatin structure formation in vertebrate cells, we developed a way to evaluate chromatin structure within a centromeric region in chicken DT40 cells quantitatively. Using the method, we found that the unique high-order structure of centromeric chromatin requires self-oligomerization of kinetochore protein CENP-C, which is crucial to accurate chromosome segregation.
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