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Elucidation of the molecular basis of individual lifespan by olfaction

Research Project

Project/Area Number 21H02479
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 44010:Cell biology-related
Research InstitutionHiroshima University

Principal Investigator

CHIHARA Takahiro  広島大学, 統合生命科学研究科(理), 教授 (00431891)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2023: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2022: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2021: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords嗅覚 / 免疫 / 老化 / ショウジョウバエ / 寿命 / オートファジー
Outline of Research at the Start

嗅覚は周囲の揮発性化学物質を感知するだけでなく、生物個体の生理状態にも影響を及ぼす。しかし、このような経験的な「匂い効果」に関する科学的な検証は未だ少ないのが現状である。本研究では、世代時間が短く、高度な遺伝学的手法を用いることが可能 なショウジョウバエを活用することで、「嗅覚はどのように個体の生理状態(特に老化)を 制御しているのか?」という問いに答えるための神経回路・分子基盤を明らかにする。更に、 ここで明らかにした知見を基に、個体の寿命を制御する“寿命延長臭(機能的臭い物質)” を同定し、嗅覚による寿命制御研究の基盤を築く。

Outline of Final Research Achievements

In order to detect individual physiological states (e.g. immunity, inflammation) related to lifespan, a genetic system for detecting the level of innate immunity was established. By using this system, we searched olfactory receptor neurons that influence the level of innate immunity, and succeeded in identifying the “A olfactory receptor neurons” (provisional name), which regulate innate immunity. The activation of “A olfactory receptor” increases the level of innate immunity in individuals. Future research will aim to elucidate the molecular mechanisms by which “A olfactory receptor” regulates innate immunity and individual aging, with the aim of elucidating the mechanisms of individual physiological control by odors.

Academic Significance and Societal Importance of the Research Achievements

老化に伴う個体機能低下に対する社会的関心は大きい。一般に老化要因として知られる食事やストレスではなく、“嗅覚”による寿命制御には大きな関心が寄せられている。今回の研究の成功は、例えば長寿効果を持つ機能性匂い物質の開発にも繋がる可能性があり、「匂うだけで健康長寿」という概念も提案できるかもしれない。今回の研究成果である「(老化にも関わる)免疫を制御する匂い神経回路の同定」は、今後の“匂いによる個体生理制御研究”の礎となるものである。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (10 results)

All 2023 2022 2021

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (8 results) (of which Invited: 2 results)

  • [Journal Article] Akaluc/AkaLumine bioluminescence system enables highly sensitive, non-invasive and temporal monitoring of gene expression in Drosophila2023

    • Author(s)
      Ito Akira、Matsuda Nagisa、Ukita Yumiko、Okumura Misako、Chihara Takahiro
    • Journal Title

      Communications Biology

      Volume: 6 Issue: 1 Pages: 1270-1270

    • DOI

      10.1038/s42003-023-05628-x

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Systemic innate immune response induces death of olfactory receptor neurons in Drosophila2022

    • Author(s)
      Kenichi Takeuchi, Daichi Honda, Misako Okumura, Masayuki Miura, Takahiro Chihara
    • Journal Title

      Genes to Cells

      Volume: 27 Issue: 2 Pages: 113-123

    • DOI

      10.1111/gtc.12914

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed
  • [Presentation] Functional analysis of olfactory receptors regulating innate immunity in Drosophila2023

    • Author(s)
      Akira Ito, Nagisa Matsuda, Yumiko Ukita, Misako Okumura, Takahiro Chihara
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Exploring the extracellular functions of ALS-related protein VAP in Drosophila2021

    • Author(s)
      Kosuke Kamemura, Misako Okumura, Takahiro Chihara
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Identification and characterization of Hiat, a novel Hippo pathway- interacting amino acid transporter2021

    • Author(s)
      本田大智, 千原崇裕, 奥村美紗子
    • Organizer
      日本発生生物学会年会第54回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Identification and characterization of Hiat, a novel Hippo pathway-interacting amino acid transporter2021

    • Author(s)
      本田大智, 千原崇裕, 奥村美紗子
    • Organizer
      14 th Japan Drosophila Research Conference
    • Related Report
      2021 Annual Research Report
  • [Presentation] Hiat, a novel Hippo pathway-interacting amino acid transporter in the regulation of synapse formation and tissue growth in Drosophila2021

    • Author(s)
      本田大智, 千原崇裕, 奥村美紗子
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Investigating the extracellular functions of ALS-related ER protein VAP in Drosophila2021

    • Author(s)
      Kosuke KAMEMURA, Misako OKUMURA, Takahiro CHIHARA
    • Organizer
      14 th Japan Drosophila Research Conference
    • Related Report
      2021 Annual Research Report
  • [Presentation] ALS関連小胞体タンパク質VAPの細胞内・外における生理機能2021

    • Author(s)
      千原崇裕
    • Organizer
      第 42 回日本基礎老化学会シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Intra- and extracellular functions of ALS-related ER protein VAP2021

    • Author(s)
      Takahiro Chihara
    • Organizer
      第64回日本神経化学会
    • Related Report
      2021 Annual Research Report
    • Invited

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Published: 2021-04-28   Modified: 2025-01-30  

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