| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2023: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2022: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2021: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Outline of Final Research Achievements |
Using a spike timing-dependent plasticity (STDP) protocol with two-photon uncaging of glutamate, we investigated the signalling pathways of plasticity in a single spine of layer 5 pyramidal neurons in an acute slice of the medial prefrontal cortex (mPFC). We newly identified that noradrenaline enhances spine plasticity via β2 receptor-mediated deinhibition of inhibitory mechanisms by microglia. Furthermore, we identified observational fear learning as a learning behaviour regulated by these mechanisms. Overall, we show new mechanisms controlling synaptic plasticity and learning in the mPFC.
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