| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2023: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2022: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2021: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
We have studied molecular mechanisms underlying retinal development, including neuronal and glial cells, synapse formation, and retinal degeneration. In the current study, we identified candidate genes involved in retinal development and function by scRNA-seq analysis. We analyzed their possible functions in the mouse retina. We generated knockout and double-knockout mice and performed electrophysiological analysis and histological analysis. We carried out inducible Muller glial cell-specific Rax knockout mice. We found that ax suppresses inflammation in Muller glial cells and regulates retinal homeostasis. We reported these results as a research journal paper.
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