| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2023: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2022: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2021: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Phosphoinositides (PIPs), which are intracellular signaling lipids, have a structure consisting of a glycerol backbone with two acyl chains and an inositol ring. PIPs are classified into seven classes based on the phosphorylation state of the inositol ring, and each class has been shown to possess unique functions. However, the specific functions of PIP molecular species determined by differences in acyl chain composition have not been elucidated.
We have developed a novel method for analyzing the functions of PIP molecular species with different acyl chain compositions and identified 75 proteins that bind to PIP molecular species associated with cancer. Additionally, we have discovered cell lines with distinctive acyl chain compositions and found that altering the acyl chain composition of PIPs by adding fatty acids affects cell proliferation.
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