| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2023: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2021: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we have shown that re-establishment of epithelial cell polarity (apico-basal polarity) involves exocytosis of vesicles derived from the intracellular apical component that is formed during a loss of cell polarity: Cdc42 plays a central role in the exocytosis. We have also clarified that Par3 promotes re-formation of tight junction and subsequent re-establishment of epithelial cell polarity by suppressing TMEM25, a novel membrane protein that inhibits claudin oligomerization. Furthermore, the present study has shown that hepatocytes require the TJ protein Par3 and the Cdc42-Par6-aPKC complex formed on the apical membrane to establish cell polarity.
|
