| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2023: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2022: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2021: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Rotavirus (RV) causes gastroenteritis and diarrhea in infants. Rotaviruses belong to the family Reoviridae and have an 11-segmented double-stranded RNA genome. Currently, two types of oral live vaccines have been introduced in many countries and have contributed significantly to the prevention of severe cases of RV. However, some problems have been pointed out. Therefore, there is an urgent need to develop next-generation vaccines and antiviral drugs.
In this study, we analyze viral (VP4 and NSP4 proteins) and host factors involved in RV infectivity and pathogenicity using the RV reverse genetics system to elucidate the replication mechanism and the pathogenesis mechanism of diarrhea in RV. Based on the obtained knowledge, we aim to establish a platform for RV infection control.
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