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Elucidation of chemoradiation resistance mechanisms for the development of new molecular target drugs for pancreatic cancer

Research Project

Project/Area Number 21H03006
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionNagoya City University

Principal Investigator

Matsuo Yoichi  名古屋市立大学, 医薬学総合研究院(医学), 教授 (40381800)

Co-Investigator(Kenkyū-buntansha) 坪井 謙  名古屋市立大学, 医薬学総合研究院(医学), 講師 (80592500)
今藤 裕之  名古屋市立大学, 医薬学総合研究院(医学), 研究員 (80790641)
林 祐一  名古屋市立大学, 医薬学総合研究院(医学), 助教 (60811726)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2023: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2022: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2021: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
KeywordsIL-1RI / 膵癌 / 抗癌剤耐性 / 血管新生 / IL-1Ra / IL-1ra / 放射線耐性 / IL-1α / IL-1RⅠ / ゲムシタビン耐性膵癌 / 放射線耐性膵癌 / IL-1RtypeⅠ / IL-Ra / 放射線体制
Outline of Research at the Start

膵癌では術前化学放射線療法が推奨されているが,ほかの癌にくらべて効果は低い.その理由に,治療に対する感受性の低さがあげられる.したがい,耐性メカニズムの解明は予後改善のブレイクスルーになる.一方,我々は,抗癌剤や放射線耐性を有する膵癌細胞株の樹立に成功し,網羅的な遺伝子解析の結果IL-1RIに着目した.我々は既に,IL-1RIを介するシグナルが膵癌の浸潤や転移に関与することを世界に先駆けて報告した.IL-1RIの拮抗薬IL-1raは他疾患で認可されており,膵癌臨床への応用が可能と考える.本研究では,抗癌剤及び放射線耐性のメカニズムの解明と,IL-1RIの機能解析および新規治療薬の開発を目指す.

Outline of Final Research Achievements

The prognosis for pancreatic cancer is extremely poor, and recurrence occurs quickly even after radical surgery. Currently, preoperative chemoradiotherapy is recommended, but it is less effective than for other cancers. One reason for this is low sensitivity to treatment. Therefore, elucidating the resistance mechanism and increasing the sensitivity of preoperative treatment will lead to truly curative surgery and will be a breakthrough in improving prognosis. Meanwhile, we succeeded in establishing a pancreatic cancer cell line that is resistant to anticancer drugs and radiation, and as a result of comprehensive genetic analysis, we focused on IL-1RI, a cell membrane receptor for pancreatic cancer. In this study, we revealed that IL-1RI expression increases with resistance, and that it contributes to the tumor progression of pancreatic cancer through NF-κB signaling.

Academic Significance and Societal Importance of the Research Achievements

今回着目したIL-1RIの拮抗薬であるIL-1R antagonist(IL-1ra)はすでに欧米で関節リウマチに対して使用されており,膵癌においても臨床応用への実現性が高いと考えている.我々の研究室ではこれまでにIL-1/ IL-1RIシグナルが転写因子NF-κBを活性化し,血管新生因子や接着能や浸潤能を制御していることを世界に先駆けて報告しているが,抗癌剤耐性化によるこれらの機能の変化は未知数である.IL-1/ IL-1RIシグナルを制御することでGem感受性を高め,浸潤や微小転移を術前に今まで以上に制御することができれば,手術の根治性が高まりさらなる予後の改善につながると考える。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (45 results)

All 2024 2023 2022 2021

All Journal Article (23 results) (of which Open Access: 21 results,  Peer Reviewed: 15 results) Presentation (22 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Expression of ZKSCAN3 protein suppresses proliferation, migration, and invasion of pancreatic cancer through autophagy2024

    • Author(s)
      Nonoyama Keisuke、Matsuo Yoichi、Sugita Saburo、Eguchi Yuki、Denda Yuki、Murase Hiromichi、Kato Tomokatsu、Imafuji Hiroyuki、Saito Kenta、Morimoto Mamoru、Ogawa Ryo、Takahashi Hiroki、Mitsui Akira、Kimura Masahiro、Takiguchi Shuji
    • Journal Title

      Cancer Science

      Volume: - Issue: 6 Pages: 1964-1978

    • DOI

      10.1111/cas.16173

    • Related Report
      2023 Annual Research Report
    • Open Access
  • [Journal Article] The Natural Product Parthenolide Inhibits Both Angiogenesis and Invasiveness and Improves Gemcitabine Resistance by Suppressing Nuclear Factor κB Activation in Pancreatic Cancer Cell Lines2024

    • Author(s)
      Denda Yuki、Matsuo Yoichi、Sugita Saburo、Eguchi Yuki、Nonoyama Keisuke、Murase Hiromichi、Kato Tomokatsu、Imafuji Hiroyuki、Saito Kenta、Morimoto Mamoru、Ogawa Ryo、Takahashi Hiroki、Mitsui Akira、Kimura Masahiro、Takiguchi Shuji
    • Journal Title

      Nutrients

      Volume: 16 Issue: 5 Pages: 705-705

    • DOI

      10.3390/nu16050705

    • Related Report
      2023 Annual Research Report
    • Open Access
  • [Journal Article] Simultaneous presentation and resection of esophageal cancer and metastasis to the pancreas: Α case report and literature review2023

    • Author(s)
      Denda Yuki、Matsuo Yoichi、Nonoyama Keisuke、Murase Hiromichi、Kato Tomokatsu、Hayashi Yuichi、Imafuji Hiroyuki、Saito Kenta、Morimoto Mamoru、Kato Hiroyuki、Yoshida Michihiro、Naitoh Itaru、Hayashi Kazuki、Ogawa Ryo、Takahashi Hiroki、Takiguchi Shuji
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 20 Issue: 1

    • DOI

      10.3892/mco.2023.2700

    • Related Report
      2023 Annual Research Report
    • Open Access
  • [Journal Article] Natural Products and Cancer2023

    • Author(s)
      Matsuo Yoichi
    • Journal Title

      Nutrients

      Volume: 15 Issue: 24 Pages: 5064-5064

    • DOI

      10.3390/nu15245064

    • Related Report
      2023 Annual Research Report
    • Open Access
  • [Journal Article] Dual role of autotaxin as novel biomarker and therapeutic target in pancreatic neuroendocrine neoplasms2023

    • Author(s)
      Toyohara Tadashi、Yoshida Michihiro
    • Journal Title

      Cancer Science

      Volume: 114 Issue: 12 Pages: 4571-4582

    • DOI

      10.1111/cas.15980

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Girdin regulates both migration and angiogenesis in pancreatic cancer cell lines2023

    • Author(s)
      Hayashi Yuichi、Matsuo Yoichi、Denda Yuki、Nonoyama Keisuke、Murase Hiromichi、Ueda Goro、Aoyama Yoshinaga、Kato Tomokatsu、Omi Kan、Imafuji Hiroyuki、Saito Kenta、Morimoto Mamoru、Ogawa Ryo、Takahashi Hiroki、Mitsui Akira、Kimura Masahiro、Takiguchi Shuji
    • Journal Title

      Oncology Reports

      Volume: 50 Issue: 3

    • DOI

      10.3892/or.2023.8606

    • Related Report
      2023 Annual Research Report
    • Open Access
  • [Journal Article] Upregulation of integrin-linked kinase enhances tumor progression in gemcitabine?resistant pancreatic cancer2023

    • Author(s)
      Murase Hiromichi、Matsuo Yoichi、Denda Yuki、Nonoyama Keisuke、Kato Tomokatsu、Aoyama Yoshinaga、Hayashi Yuichi、Imafuji Hiroyuki、Saito Kenta、Morimoto Mamoru、Ogawa Ryo、Takahashi Hiroki、Mitsui Akira、Kimura Masahiro、Takiguchi Shuji
    • Journal Title

      Oncology Reports

      Volume: 50 Issue: 3

    • DOI

      10.3892/or.2023.8601

    • Related Report
      2023 Annual Research Report
    • Open Access
  • [Journal Article] Elevated Preoperative Serum Vascular Endothelial Growth Factor Does Not Predict Poor Outcomes in Curatively Resected Non-metastatic Colorectal Cancer Treated Without Neoadjuvant Therapy2023

    • Author(s)
      NAKAI NOZOMU、MAEDA ANRI、YANAGITA TAKESHI、SUZUKI TAKUYA、MAEDA YUZO、HIROKAWA TAKAHISA、SHIGA KAZUYOSHI、HARA MASAYASU、TAKAHASHI HIROKI、OGAWA RYO、MATSUO YOICHI、TAKIGUCHI SHUJI
    • Journal Title

      Anticancer Research

      Volume: 43 Issue: 5 Pages: 2333-2341

    • DOI

      10.21873/anticanres.16398

    • Related Report
      2023 Annual Research Report
  • [Journal Article] The cisplatin-induced acute kidney injury is a novel risk factor for postoperative complications in patients with esophageal cancer: a retrospective cohort study2023

    • Author(s)
      Ueno Shuhei、Murashima Miho、Ogawa Ryo、Saito Masaki、Ito Sunao、Hayakawa Shunsuke、Okubo Tomotaka、Sagawa Hiroyuki、Tanaka Tatsuya、Takahashi Hiroki、Matsuo Yoichi、Mitsui Akira、Kimura Masahiro、Hamano Takayuki、Takiguchi Shuji
    • Journal Title

      BMC Surgery

      Volume: 23 Issue: 1

    • DOI

      10.1186/s12893-023-01949-0

    • Related Report
      2023 Annual Research Report
  • [Journal Article] AZD6738 promotes the tumor suppressive effects of trifluridine in colorectal cancer cells2023

    • Author(s)
      Harata Shinnosuke、Suzuki Takuya、Takahashi Hiroki、Hirokawa Takahisa、Kato Akira、Watanabe Kaori、Yanagita Takeshi、Ushigome Hajime、Shiga Kazuyoshi、Ogawa Ryo、Mitsui Akira、Kimura Masahiro、Matsuo Yoichi、Takiguchi Shuji
    • Journal Title

      Oncology Reports

      Volume: 49 Issue: 3

    • DOI

      10.3892/or.2023.8489

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relevance of gene mutations and methylation to the growth of pancreatic intraductal papillary mucinous neoplasms based on pyrosequencing.2022

    • Author(s)
      Asano, G., Miyabe, K., Kato, H., Yoshida, M., Sawada, T., Okamoto, Y., Sahashi, H., Atsuta, N., Kachi, K., Kato, A., Jinno, N., Natsume, M., Hori, Y., Naitoh, I., Hayashi, K., Matsuo, Y., Takahashi, S., Suzuki, H., Kataoka, H.
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 419-419

    • DOI

      10.1038/s41598-021-04335-z

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serous Cystic Neoplasm With Typical Clinical Findings and Perineural Invasion2022

    • Author(s)
      Hirokawa T, Kobayashi M, Ueda G, Shamoto T, Mitsui A, Kuwabara Y, Ogawa R, Takahashi H, Matsuo Y, Takahashi S, Takiguchi S.
    • Journal Title

      Pancreas

      Volume: 51 Issue: 4 Pages: e69-e71

    • DOI

      10.1097/mpa.0000000000002038

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced CXCL12/CXCR4 signaling increases tumor progression in radiation-resistant pancreatic cancer2022

    • Author(s)
      Kato Tomokatsu、Matsuo Yoichi、Ueda Goro、Murase Hiromichi、Aoyama Yoshinaga、Omi Kan、Hayashi Yuichi、Imafuji Hiroyuki、Saito Kenta、Morimoto Mamoru、Ogawa Ryo、Takahashi Hiroki、Takiguchi Shuji
    • Journal Title

      Oncology Reports

      Volume: 47 Issue: 4 Pages: 68-68

    • DOI

      10.3892/or.2022.8279

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Interaction Between Cancer-associated Fibroblasts and Cancer Cells Enhances Bcl-xL and Mcl-1 in Colorectal Cancer2022

    • Author(s)
      MAEDA ANRI、TAKAHASHI HIROKI、HARATA SHINNOSUKE、WATANABE KAORI、YANAGITA TAKESHI、SUZUKI TAKUYA、USHIGOME HAJIME、NAKAI NOZOMU、MAEDA YUZO、HIROKAWA TAKAHISA、SHIGA KAZUYOSHI、OGAWA RYO、HARA MASAYASU、MATSUO YOICHI、MITSUI AKIRA、KIMURA MASAHIRO、TAKIGUCHI SHUJI
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 3 Pages: 1277-1288

    • DOI

      10.21873/anticanres.15594

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness of a novel semi‐closed barrier device with a personalized exhaust in cough aerosol simulation according to particle counts and visualization of particles2022

    • Author(s)
      Matsui Ryohei、Sasano Hiroshi、Azami Takafumi、Yano Hisako、Yoshikawa Hiromi、Yamagishi Yota、Goshima Takahiro、Miyazaki Yuka、Imai Kazunori、Tsubouchi Marechika、Matsuo Yoichi、Takiguchi Shuji、Hattori Tomonori
    • Journal Title

      Indoor Air

      Volume: 32 Issue: 2

    • DOI

      10.1111/ina.12988

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cancer cell-induced tissue inhibitor of metalloproteinase?1 secretion by cancer-associated fibroblasts promotes cancer cell migration2022

    • Author(s)
      Nakai Nozomu、Hara Masayasu、Takahashi Hiroki、Shiga Kazuyoshi、Hirokawa Takahisa、Maeda Yuzo、Yanagita Takeshi、Ando Nanako、Takasu Korehito、Suzuki Takuya、Maeda Anri、Ogawa Ryo、Matsuo Yoichi、Takiguchi Shuji
    • Journal Title

      Oncology Reports

      Volume: 47 Issue: 6

    • DOI

      10.3892/or.2022.8323

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ATR inhibitor AZD6738 increases the sensitivity of colorectal cancer cells to 5-fluorouracil by inhibiting repair of DNA damage2022

    • Author(s)
      Suzuki Takuya、Hirokawa Takahisa、Maeda Anri、Harata Shinnosuke、Watanabe Kaori、Yanagita Takeshi、Ushigome Hajime、Nakai Nozomi、Maeda Yuzo、Shiga Kazuyoshi、Ogawa Ryo、Mitsui Akira、Kimura Masahiro、Matsuo Yoichi、Takahashi Hiroki、Takiguchi Shuji
    • Journal Title

      Oncology Reports

      Volume: 47 Issue: 4

    • DOI

      10.3892/or.2022.8289

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 10Z-Hymenialdisine inhibits angiogenesis by suppressing NF-κB activation in pancreatic cancer cell lines2022

    • Author(s)
      Ueda Goro、Matsuo Yoichi、Murase Hiromichi、Aoyama Yoshinaga、Kato Tomokatsu、Omi Kan、Hayashi Yuichi、Imafuji Hiroyuki、Saito Kenta、Tsuboi Ken、Morimoto Mamoru、Ogawa Ryo、Takahashi Hiroki、Mitsui Akira、Kimura Masahiro、Takiguchi Shuji
    • Journal Title

      Oncology Reports

      Volume: 47 Issue: 3

    • DOI

      10.3892/or.2022.8259

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lactoferrin Prevents Hepatic Injury and Fibrosis via the Inhibition of NF-κB Signaling in a Rat Non-Alcoholic Steatohepatitis Model2021

    • Author(s)
      Aoyama Yoshinaga、Naiki-Ito Aya、Xiaochen Kuang、Komura Masayuki、Kato Hiroyuki、Nagayasu Yuko、Inaguma Shingo、Tsuda Hiroyuki、Tomita Mamoru、Matsuo Yoichi、Takiguchi Shuji、Takahashi Satoru
    • Journal Title

      Nutrients

      Volume: 14 Issue: 1 Pages: 42-42

    • DOI

      10.3390/nu14010042

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DPYD, down-regulated by the potentially chemopreventive agent luteolin, interacts with STAT3 in pancreatic cancer2021

    • Author(s)
      Kato H, Naiki-Ito A, Suzuki S, Inaguma S, Komura M, Nakao K, Naiki T, Kachi K, Kato A, Matsuo Y, Takahashi S.
    • Journal Title

      Carcinogenesis

      Volume: - Issue: 7 Pages: 940-950

    • DOI

      10.1093/carcin/bgab017

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum IgG level is a predicting factor for the response to neoadjuvant chemotherapy in patients with esophageal squamous cell carcinoma2021

    • Author(s)
      Nakaya Seiichi、Ogawa Ryo、Hayakawa Shunsuke、Fujihata Shiro、Okubo Tomotaka、Sagawa Hiroyuki、Tanaka Tatsuya、Takahashi Hiroki、Matsuo Yoichi、Takiguchi Shuji
    • Journal Title

      World Journal of Surgical Oncology

      Volume: 19 Issue: 1

    • DOI

      10.1186/s12957-021-02290-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Escin inhibits angiogenesis by suppressing interleukin?8 and vascular endothelial growth factor production by blocking nuclear factor?κB activation in pancreatic cancer cell lines2021

    • Author(s)
      Omi Kan、Matsuo Yoichi、Ueda Goro、Aoyama Yoshinaga、Kato Tomokatsu、Hayashi Yuichi、Imafuji Hiroyuki、Saito Kenta、Tsuboi Ken、Morimoto Mamoru、Ogawa Ryo、Takahashi Hiroki、Takiguchi Shuji
    • Journal Title

      Oncology Reports

      Volume: 45 Issue: 5 Pages: 1-9

    • DOI

      10.3892/or.2021.8006

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A hybrid approach for chronic pancreatitis: combination of laparoscopic assisted distal pancreatectomy and open Frey procedure2021

    • Author(s)
      Saito Kenta、Matsuo Yoichi、Ueda Goro、Omi Kan、Hayashi Yuichi、Imafuji Hiroyuki、Tsuboi Ken、Morimoto Mamoru、Ogawa Ryo、Takahashi Hiroki、Naitoh Itaru、Hayashi Kazuki、Kataoka Hiromi、Takiguchi Shuji
    • Journal Title

      BMC Surgery

      Volume: 21 Issue: 1

    • DOI

      10.1186/s12893-021-01096-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 新規治療薬開発に向けた抗癌剤耐性膵癌におけるIntegrin-linked kinase(ILK)の機能解析2023

    • Author(s)
      村瀬寛倫,松尾洋一,傳田悠貴,野々山敬介,加藤知克,林祐一,今藤裕之,齊藤健太,森本守,小川了,高橋広城,三井章,木村昌弘,瀧口修司
    • Organizer
      第123回日本外科学会定期学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 臨床応用を目的とした膵癌におけるZKSCAN3の機能解析2023

    • Author(s)
      々山敬介,松尾洋一,傳田悠貴,村瀬寛倫,加藤知克,林祐一,今藤裕之,齊藤健太,森本守,小川了,高橋広城,三井章,木村昌弘,瀧口修司
    • Organizer
      第123回日本外科学会定期学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 外科医療から見た膵癌に対するゲノム医療の問題点と今後の展望2023

    • Author(s)
      松尾洋一,傳田悠貴,野々山敬介,村瀬寛倫,加藤知克,林祐一,今藤裕之,齊藤健太,社本智也,坪井謙,森本守,小川了,高橋広城,三井章,木村昌弘,瀧口修司
    • Organizer
      第123回日本外科学会定期学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 抗癌剤耐性膵癌で発現が亢進するIntegrin-linked kinase(ILK)を標的とした新規治療薬の開発2023

    • Author(s)
      村瀬寛倫,松尾洋一,傳田悠貴,野々山敬介,加藤知克,林祐一,今藤裕之,齊藤健太,森本守,小川了,高橋広城,三井章,木村昌弘,瀧口修司
    • Organizer
      第27回がん分子標的治療学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ZKSCAN3タンパク発現は膵癌の増殖,遊走,浸潤を抑制する2023

    • Author(s)
      野々山敬介,松尾洋一,傳田悠貴,村瀬寛倫,加藤知克,今藤裕之,齋藤健太,森本守,小川了,高橋広城,瀧口修司
    • Organizer
      第82回日本癌学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 癌幹細胞マーカーCXCR4に着目した膵癌における化学放射線耐性メカニズムの解明と治療応用2023

    • Author(s)
      松尾洋一,杉田三郎,江口祐輝,傳田悠貴,野々山敬介,村瀬 寛倫,加藤知克,林祐一,今藤裕之,齊藤健太,社本智也,坪井謙,森本守,小川了,高橋広城,瀧口修司
    • Organizer
      第34回日本消化器癌発生学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Development of novel therapeutic agents for pancreatic cancer from the perspective of precision medicine and cancer stem cell markers2023

    • Author(s)
      Yoichi MATSUO Saburo SUGITA, Yuki EGUCHI, Yuki DENDA, Keisuke NONOYAMA, Hiromichi MURASE, Tomokatsu KATO, Hiroyuki IMAFUJI, Kenta SAITO, Tomoya SHAMOTO, Ken TSUBOI, Mamoru MORIMOTO, Ryo OGAWA, Hiroki TAKAHASHI, Akira MITSUI, Masahiro KIMURA, Shuji TAKIGUCHI
    • Organizer
      Korean Society of Medical Oncology
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 手術侵襲と炎症がもたらす膵癌再発の分子論2022

    • Author(s)
      松尾洋一
    • Organizer
      第122回日本外科学会定期学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Elucidation of the carcinogenic mechanism of chronic pancreatitis from the viewpoint of interaction with stroma2022

    • Author(s)
      松尾洋一
    • Organizer
      第26回国際膵臓学会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nutrition therapy for pancreatic disease:expectations for zinc administration therapy2022

    • Author(s)
      松尾洋一
    • Organizer
      第26回国際膵臓学会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 膵癌の進展・浸潤に関与する新たな分子生物学的マーカーの開発2022

    • Author(s)
      松尾洋一
    • Organizer
      第60回日本癌治療学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 臨床応用を意識した膵癌における薬剤・放射線耐性メカニズムの解明と新規分子標的2022

    • Author(s)
      松尾洋一
    • Organizer
      第33回日本消化器癌発生学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 膵癌の発癌、進行および治療耐性に対するがん微小環境の関与2022

    • Author(s)
      松尾洋一
    • Organizer
      第109回日本消化器病学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 臨床応用を目指した消化器癌におけるProtein Kinase D(PKD)の機能解析2021

    • Author(s)
      松尾洋一
    • Organizer
      第32回日本消化器癌発生学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 膵癌治療抵抗性の機序解明に基づく新たな治療法の開発2021

    • Author(s)
      松尾洋一
    • Organizer
      第29回日本癌病態治療研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 膵癌微小環境におけるサイトカインネットワークの機能解析2021

    • Author(s)
      松尾洋一
    • Organizer
      第51回日本膵臓学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] K-ras遺伝子変異と炎症性サイトカインに着目した慢性膵炎の発癌メカニズムの解明2021

    • Author(s)
      松尾洋一
    • Organizer
      第51回日本膵臓学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Development of a novel therapeutic agent against pancreatic cancer angiogenesis targeting NF-κB2021

    • Author(s)
      松尾洋一
    • Organizer
      第32回日本肝胆膵外科学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 当科における分子細胞治療研究2021

    • Author(s)
      松尾洋一
    • Organizer
      第23回外科分子細胞治療研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 新規治療薬の開発を目指した消化器癌におけるProtein Kinase Dの機能解析2021

    • Author(s)
      松尾洋一
    • Organizer
      第42回癌免疫外科研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 膵癌の転移メカニズムを血管新生から考える2021

    • Author(s)
      松尾洋一
    • Organizer
      第30回日本がん転移学会学術集会・総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 微小環境との相互作用からみた肺癌の進展メカニズムの解明と新規治療薬の開発2021

    • Author(s)
      松尾洋一
    • Organizer
      第52回日本膵臓学会大会
    • Related Report
      2021 Annual Research Report

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Published: 2021-04-28   Modified: 2025-01-30  

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