Regulation of bone homeostasis and aging from calcium and phosphorus metabolism

• Project/Area Number: 21H03057
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Kumamoto University
• Principal Investigator: Miyamoto Takeshi 熊本大学, 大学院生命科学研究部(医), 教授 (70383768)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2023: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2022: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2021: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
• Keywords: 整形外科 / 骨粗鬆症 / 骨恒常性制御

Outline of Research at the Start

骨粗鬆症及び脆弱性骨折患者数は、今日の超高齢社会に到来を受けて増加の一途を辿っており、医療経済的な面からもその対策は喫緊の課題となっています。骨粗鬆症は単に骨のみの疾患ではなく、全身的なカルシウム・リン代謝の恒常性制御機構の破綻により発症することから、その制御系の理解は疾患発症メカニズムの理解に必須です。本研究では、骨粗鬆症をカルシウム・リン代謝の恒常性制御機構の破綻した疾患として、そのメカニズムの解明を目指します。

Outline of Final Research Achievements

We clarified that ectopic calcium deposition is a cause of reduced bone mineral density in mice. We found that ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1), a single transmembrane molecule, plays an essential role in calcium deposition in bone, and that its dysfunction causes ectopic ossification and bone loss by using Enpp1-deficient (Enpp1 KO) mice. Furthermore, we found that Enpp1 is expressed primarily in articular chondrocytes and regulates systemic aging and ectopic calcification from articular cartilage.

Academic Significance and Societal Importance of the Research Achievements

骨粗鬆症の患者数ならびに脆弱性骨折の発生数は増大の一途を辿っている。すでに多くの骨粗鬆症治療薬が開発・上市されているにも関わらず、このような傾向が持続している事実から、新たな骨粗鬆症の発症機序の解明に基づく治療法の開発が必要と考えられた。今回、Enpp1欠損マウスを用いた解析により、異所性の石灰沈着が骨密度低下の直接の原因となり得ること、全身的な老化を含めた骨密度制御が、関節軟骨に発現するEnpp1によって担われているという新しい概念を見出した点で学術的意義がある。また、今後の新たな骨粗鬆症治療薬を開発するための機序を解明した点で、社会的にも意義があると考えている。

Research Products

• [Journal Article] Bezafibrate attenuates immobilization-induced muscle atrophy in mice (2024)
  • Author(s): Nakamura Satoshi、Sato Yuiko、Kobayashi Tami、Oya Akihito、Fujie Astuhiro、Matsumoto Morio、Nakamura Masaya、Kanaji Arihiko、Miyamoto Takeshi
  • Journal Title: Scientific Reports Volume: 14 Issue: 1
  • DOI: 10.1038/s41598-024-52689-x
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between physical activity and locomotive syndrome among young and middle-aged Japanese workers (2024)
  • Author(s): Watanabe Kazuhiko、Lu Xi、Masuda Shota、Miyamoto Takeshi、Katoh Takahiko
  • Journal Title: Journal of Occupational Health Volume: 66 Issue: 1 Pages: n/a
  • DOI: 10.1093/joccuh/uiae001
  • ISSN: 1341-9145, 1348-9585
  • Peer Reviewed
• [Journal Article] Cartilage tissues regulate systemic aging via ectonucleotide pyrophosphatase/phosphodiesterase 1 in mice (2024)
  • Author(s): Arima Takahiro、Taniwaki Takuya、et al.
  • Journal Title: Journal of Biological Chemistry Volume: 300 Issue: 1 Pages: 105512-105512
  • DOI: 10.1016/j.jbc.2023.105512
  • Peer Reviewed
• [Journal Article] Lateral Laxity in Flexion Influences Patient-Reported Outcome After Total Knee Arthroplasty (2023)
  • Author(s): Okamoto Nobukazu、Nakamura Eiichi、Masuda Tetsuro、Hisanaga Satoshi、Miyamoto Takeshi
  • Journal Title: Indian Journal of Orthopaedics Volume: 58 Issue: 1 Pages: 24-29
  • DOI: 10.1007/s43465-023-01045-8
  • Peer Reviewed
• [Journal Article] The IL-17-IL-17RA axis is required to promote osteosarcoma progression in mice (2023)
  • Author(s): Yoshimura Naoto and Miyamoto Takeshi et al.
  • Journal Title: Scientific Reports Volume: 13 Issue: 1
  • DOI: 10.1038/s41598-023-49016-1
  • Peer Reviewed / Open Access
• [Journal Article] A machine learning-based scoring system and ten factors associated with hip fracture occurrence in the elderly (2023)
  • Author(s): Uragami Masaru、Matsushita Kozo、Shibata Yuto、Takata Shu、… Kajitani Naoto、Uehara Yusuke、Miyamoto Takeshi
  • Journal Title: Bone Volume: 176 Pages: 116865-116865
  • DOI: 10.1016/j.bone.2023.116865
  • Peer Reviewed
• [Journal Article] Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis (2023)
  • Author(s): Iga Takahito、Kobayashi Hiroshi、Kusumoto Dai、Sanosaka Tsukasa、Fujita Nobuyuki、Tai-Nagara Ikue、Ando Tomofumi、Takahashi Tomoko et.al
  • Journal Title: Nature Cell Biology Volume: 25 Issue: 10 Pages: 1415-1425
  • DOI: 10.1038/s41556-023-01240-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genetic insights into ossification of the posterior longitudinal ligament of the spine (2023)
  • Author(s): Koike Yoshinao、Inose Hiroyuki, et al.
  • Journal Title: eLife Volume: 12 Pages: 86514-86514
  • DOI: 10.7554/elife.86514
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Potential function of Scx+/Sox9+ cells as progenitor cells in rotator cuff tear repair in rats (2023)
  • Author(s): Yuko Fukuma; Takuya Tokunaga; Shuntaro Tanimura; Yuki Yoshimoto; Tomoji Mashimo; Takehito Kaneko; Tian Xiao; Katsumasa Ideo; Ryuji Yonemitsu; Kozo Matsushita; Kazuki Sugimoto; Masaki Yugami; Satoshi Hisanaga; Takayuki Nakamura; Yusuke Uehara; Tetsuro Masuda; Chisa Shukunami; Tatsuki Karasugi; Takeshi Miyamoto
  • Journal Title: Biochem Biophys Res Commun . Volume: 676 Pages: 84-90
  • DOI: 10.1016/j.bbrc.2023.07.039
  • Peer Reviewed
• [Journal Article] Transthyretin amyloid deposition in ligamentum flavum (LF) is significantly correlated with LF and epidural fat hypertrophy in patients with lumbar spinal stenosis (2023)
  • Author(s): Maeda Kazuya、Taniwaki Takuya、et al.
  • Journal Title: Scientific Reports Volume: 13 Issue: 1
  • DOI: 10.1038/s41598-023-47282-7
  • Peer Reviewed / Open Access
• [Journal Article] Remnant tissue enhances early postoperative biomechanical strength and infiltration of Scleraxis-positive cells within the grafted tendon in a rat anterior cruciate ligament reconstruction model (2023)
  • Author(s): Kawakami Junki, Hisanaga Satoshi ,Yoshimoto Yuki (他11名) Okamoto Nobukazu、Masuda Tetsuro、Miyamoto Takeshi
  • Journal Title: PLOS ONE Volume: 18 Issue: 11 Pages: 0293944-0293944
  • DOI: 10.1371/journal.pone.0293944
  • Peer Reviewed / Open Access
• [Journal Article] Combination Use of Compressed Sensing and Deep Learning for Shoulder Magnetic Resonance Imaging With Various Sequences (2023)
  • Author(s): Shiraishi Kaori、Nakaura Takeshi、Uetani Hiroyuki、Nagayama Yasunori、Kidoh Masafumi、Kobayashi Naoki、Morita Kosuke、Yamahita Yuichi、Miyamoto Takeshi、Hirai Toshinori
  • Journal Title: Journal of Computer Assisted Tomography Volume: 47 Pages: 277-283
  • DOI: 10.1097/rct.0000000000001418
  • Peer Reviewed
• [Journal Article] TNFα-dependent mTOR activity is required for tenotomy-induced ectopic ossification in mice (2023)
  • Author(s): Kushima Yu、Sato Yuiko、Kobayashi Tami、Fukuma Yuko、Matsumoto Morio、Nakamura Masaya、Iwamoto Takuji、Miyamoto Takeshi
  • Journal Title: Journal of Bone and Mineral Metabolism Volume: 41 Issue: 5 Pages: 583-591
  • DOI: 10.1007/s00774-023-01437-8
  • Peer Reviewed
• [Journal Article] Osteoporosis and sarcopenia are associated with each other and reduced IGF1 levels are a risk for both diseases in the very old elderly (2023)
  • Author(s): Hata Ryosuke、Miyamoto Kana、Abe Yukiko、Sasaki Takashi、Oguma Yuko、Tajima Takayuki、Arai Yasumichi、Matsumoto Morio、Nakamura Masaya、Kanaji Arihiko、Miyamoto Takeshi
  • Journal Title: Bone Volume: 166 Pages: 116570-116570
  • DOI: 10.1016/j.bone.2022.116570
  • Peer Reviewed / Open Access
• [Journal Article] The remaining teres minor and subscapularis may contribute to preventing superior migration of the humeral head and progression of osteoarthritic change in rotator cuff tears (2023)
  • Author(s): Tamura Toshifumi、Tokunaga Takuya、Karasugi Tatsuki、Miyamoto Takeshi、Kikukawa Kenshi
  • Journal Title: JSES International Volume: 7 Issue: 4 Pages: 561-567
  • DOI: 10.1016/j.jseint.2023.03.005
  • Peer Reviewed
• [Journal Article] Association of Severe Histological Degeneration of the Torn Supraspinatus Tendon and Retear After Arthroscopic Repair of Full-Thickness Rotator Cuff Tears Using the Suture Bridge Technique (2023)
  • Author(s): Tokunaga Takuya、Karasugi Tatsuki、Tanimura Shuntaro、Miyamoto Takeshi
  • Journal Title: The American Journal of Sports Medicine Volume: 51 Issue: 9 Pages: 2411-2421
  • DOI: 10.1177/03635465231178294
  • Peer Reviewed
• [Journal Article] Low energy availability reduces bone mass and gonadal function in male mice (2023)
  • Author(s): Ito Eri、Sato Yuiko、Kobayashi Tami、Soma Tomoya、Matsumoto Tatsuaki、Kimura Atushi、Miyamoto Kana、Matsumoto Hideo、Matsumoto Morio、Nakamura Masaya、Sato Kazuki、Miyamoto Takeshi
  • Journal Title: Journal of Bone and Mineral Metabolism Volume: 41 Issue: 2 Pages: 182-192
  • DOI: 10.1007/s00774-023-01413-2
  • Peer Reviewed
• [Journal Article] Assessment of the Necessity of Osteoporosis Treatment for Patients with Low Bone Density in Diffuse Idiopathic Skeletal Hyperostosis (2022)
  • Author(s): Furukawa Mitsuru、Okuyama Kunimasa、Ninomiya Ken、Miyamoto Takeshi、Yato Yoshiyuki
  • Journal Title: Spine Surgery and Related Research Volume: 6 Issue: 5 Pages: 526-532
  • DOI: 10.22603/ssrr.2021-0149
  • ISSN: 2432-261X
  • Year and Date: 2022-09-27
  • Peer Reviewed
• [Journal Article] Psoas Major Skeletal Muscle Mass Is a Predictive Factor for Independent Walking After Living Donor Liver Transplantation (2022)
  • Author(s): Kodama Satoru、Togami Wakana、Miyamoto Takeshi
  • Journal Title: Transplantation Proceedings Volume: 54 Issue: 8 Pages: 2285-2294
  • DOI: 10.1016/j.transproceed.2022.08.002
  • Peer Reviewed
• [Journal Article] Transcription Factor Hematopoietically Expressed Homeobox Protein (Hhex) Negatively Regulates Osteoclast Differentiation by Controlling Cyclin‐Dependent Kinase Inhibitors (2022)
  • Author(s): Watanabe Hisato、Okada Hiroyuki、Hirose Jun、Omata Yasunori、Matsumoto Takumi、Matsumoto Morio、Nakamura Masaya、Saito Taku、Miyamoto Takeshi、Tanaka Sakae
  • Journal Title: JBMR Plus Volume: 6 Issue: 4
  • DOI: 10.1002/jbm4.10608
  • Peer Reviewed / Open Access
• [Journal Article] An ionic silver coating prevents implant-associated infection by anaerobic bacteria in vitro and in vivo in mice (2022)
  • Author(s): Soma Tomoya、Iwasaki Ryotaro、Sato Yuiko、Kobayashi Tami、Ito Eri、Matsumoto Tatsuaki、Kimura Atsushi、Homma Fuka、Saiki Keitarou、Takahashi Yukihiro、Miyamoto Kana、Matsumoto Morio、Nakamura Masaya、Morita Mayu、Ishii Ken、Asoda Seiji、Kawana Hiromasa、Xingyu Zhu、Aizawa Mamoru、Nakagawa Taneaki、Miyamoto Takeshi
  • Journal Title: Scientific Reports Volume: 12 Issue: 1
  • DOI: 10.1038/s41598-022-23322-6
  • Peer Reviewed / Open Access
• [Journal Article] The Stat3 inhibitor F0648-0027 is a potential therapeutic against rheumatoid arthritis (2022)
  • Author(s): Kaneko Yosuke、Ozawa Shin-ichiro、Sato Yuiko、Kobayashi Tami、Matsumoto Tatsuaki、Miyamoto Kana、Kobayashi Shu、Harato Kengo、Hirono Shuichi、Matsumoto Morio、Nakamura Masaya、Niki Yasuo、Miyamoto Takeshi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 636 Pages: 133-140
  • DOI: 10.1016/j.bbrc.2022.10.106
  • Peer Reviewed
• [Journal Article] Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study (2022)
  • Author(s): Yin Xianyong、Kim Kwangwoo、Tsutomu Takeuchi, et al.
  • Journal Title: Annals of the Rheumatic Diseases Volume: 81 Issue: 9 Pages: 1273-1280
  • DOI: 10.1136/annrheumdis-2022-222345
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hao1 Is Not a Pathogenic Factor for Ectopic Ossifications but Functions to Regulate the TCA Cycle In Vivo (2022)
  • Author(s): Kimura Atsushi、Hirayama Akiyoshi、Matsumoto Tatsuaki、Sato Yuiko、Kobayashi Tami、Ikeda Satsuki、Maruyama Midori、Kaneko Mari、Shigeta Mayo、Ito Eri、Soma Tomoya、Miyamoto Kana、Soga Tomoyoshi、Tomita Masaru、Oya Akihito、Matsumoto Morio、Nakamura Masaya、Kanaji Arihiko、Miyamoto Takeshi
  • Journal Title: Metabolites Volume: 12 Issue: 1 Pages: 82-82
  • DOI: 10.3390/metabo12010082
  • Peer Reviewed / Open Access
• [Journal Article] A novel fabrication process of up-scalable microfiber-shaped tendon-like tissue with high cell density for uniformed macroscale assembly (2022)
  • Author(s): Keisuke Fukada, Koji Tachibana, Yuta Kurashina, Yosuke Kaneko, Tatsuaki Matsumoto, Takeshi Miyamoto, Yasuo Niki, Masaya Nakamura, Hiroaki Onoe
  • Journal Title: Biotechnology and Bioengineering Volume: 119 Issue: 5 Pages: 1327-1336
  • DOI: 10.1002/bit.28039
  • Peer Reviewed
• [Journal Article] Osteonecrosis development by tooth extraction in zoledronate treated mice is inhibited by active vitamin D analogues, anti-inflammatory agents or antibiotics (2022)
  • Author(s): Soma Tomoya、Iwasaki Ryotaro、Sato Yuiko、Kobayashi Tami、Ito Eri、Matsumoto Tatsuaki、Kimura Atsushi、Miyamoto Kana、Matsumoto Morio、Nakamura Masaya、Morita Mayu、Asoda Seiji、Kawana Hiromasa、Nakagawa Taneaki、Miyamoto Takeshi
  • Journal Title: Scientific Reports Volume: 12 Issue: 1
  • DOI: 10.1038/s41598-021-03966-6
  • Peer Reviewed / Open Access
• [Journal Article] Association of Continuous Vertebral Bone Bridges and Bone Mineral Density with the Fracture Risk in Patients with Diffuse Idiopathic Skeletal Hyperostosis (2022)
  • Author(s): Furukawa Mitsuru、Okuyama Kunimasa、Ninomiya Ken、Yato Yoshiyuki、Miyamoto Takeshi、Nakamura Masaya、Matsumoto Morio
  • Journal Title: Asian Spine Journal Volume: 16 Issue: 1 Pages: 75-81
  • DOI: 10.31616/asj.2020.0352
  • Peer Reviewed
• [Journal Article] Maximum number of bone cross-linked vertebrae: an index for BMD in diffuse idiopathic skeletal hyperostosis (2021)
  • Author(s): Furukawa Mitsuru、Okuyama Kunimasa、Ninomiya Ken、Yato Yoshiyuki、Miyamoto Takeshi、Nakamura Masaya、Matsumoto Morio
  • Journal Title: Journal of Bone and Mineral Metabolism Volume: 40 Issue: 2 Pages: 308-316
  • DOI: 10.1007/s00774-021-01282-7
  • Peer Reviewed
• [Journal Article] Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus (2021)
  • Author(s): Suetsugu Hiroyuki、Kim Kwangwoo、Yamamoto Takuaki、Bang So-Young、Sakamoto Yuma、Shin Jung-Min、Sugano Nobuhiko、Kim Ji Soong、Mukai Masaya、Lee Yeon-Kyung、Ohmura Koichiro、Park Dae Jin、Takahashi Daisuke、Ahn Ga-Young、Karino Kohei、Kwon Young-Chang、Miyamura Tomoya、Kim Jihye、Nakamura Junichi、et al
  • Journal Title: Human Molecular Genetics Volume: 31 Issue: 7 Pages: 1082-1095
  • DOI: 10.1093/hmg/ddab306
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Smad2 and Smad3 expressed in skeletal muscle promote immobilization-induced bone atrophy in mice (2021)
  • Author(s): Umezu Taro、Nakamura Satoshi、Sato Yuiko、Kobayashi Tami、Ito Eri、Abe Takaya、Kaneko Mari、Nomura Masatoshi、Yoshimura Akihiko、Oya Akihito、Matsumoto Morio、Nakamura Masaya、Kanaji Arihiko、Miyamoto Takeshi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 582 Pages: 111-117
  • DOI: 10.1016/j.bbrc.2021.10.043
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Adipose-Derived Stem Cell Sheets Improve Early Biomechanical Graft Strength in Rabbits After Anterior Cruciate Ligament Reconstruction (2021)
  • Author(s): Matsumoto Tatsuaki、Sato Yuiko、Kobayashi Tami、Suzuki Kunika、Kimura Atsushi、Soma Tomoya、Ito Eri、Kikuchi Toshiyuki、Kobayashi Shu、Harato Kengo、Niki Yasuo、Matsumoto Morio、Nakamura Masaya、Miyamoto Takeshi
  • Journal Title: The American Journal of Sports Medicine Volume: 49 Issue: 13 Pages: 3508-3518
  • DOI: 10.1177/03635465211041582
  • Peer Reviewed
• [Journal Article] Transient alendronate administration to pregnant or lactating mothers prevents bone loss in mice without adverse effects on offspring (2021)
  • Author(s): Ito Eri、Sato Yuiko、Kobayashi Tami、Soma Tomoya、Matsumoto Tatsuaki、Kimura Atsushi、Miyamoto Kana、Matsumoto Hideo、Matsumoto Morio、Nakamura Masaya、Sato Kazuki、Miyamoto Takeshi
  • Journal Title: Bone Volume: 153 Pages: 116133-116133
  • DOI: 10.1016/j.bone.2021.116133
  • Peer Reviewed
• [Journal Article] Acetaldehyde exposure underlies functional defects in monocytes induced by excessive alcohol consumption (2021)
  • Author(s): Shiba Shunsuke、Nakamoto Nobuhiro、Chu Po-Sung、Ojiro Keisuke、Taniki Nobuhito、Yamaguchi Akihiro、Morikawa Rei、Katayama Tadashi、Yoshida Aya、Aoki Ryo、Teratani Toshiaki、Suzuki Takahiro、Miyamoto Takeshi、Hara Sachiko、Yokoyama Akira、Kanai Takanori
  • Journal Title: Scientific Reports Volume: 11 Issue: 1
  • DOI: 10.1038/s41598-021-93086-y
  • Peer Reviewed / Open Access
• [Journal Article] Age-related amyloidosis outside the brain: A state-of-the-art review (2021)
  • Author(s): Tasaki M, Lavatelli F, Obici L, Obayashi K, Miyamoto T, Merlini G, Palladini G, Ando Y, Ueda M.
  • Journal Title: Ageing Res Rev Volume: 70 Pages: 101388-101388
  • DOI: 10.1016/j.arr.2021.101388
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Metabolomic Profile Predictive of New Osteoporosis or Sarcopenia Development (2021)
  • Author(s): Miyamoto Kana、Hirayama Akiyoshi、Sato Yuiko、Ikeda Satsuki、Maruyama Midori、Soga Tomoyoshi、Tomita Masaru、Nakamura Masaya、Matsumoto Morio、Yoshimura Noriko、Miyamoto Takeshi
  • Journal Title: Metabolites Volume: 11 Issue: 5 Pages: 278-278
  • DOI: 10.3390/metabo11050278
  • Peer Reviewed / Open Access
• [Journal Article] Synoviolin is not a pathogenic factor for auto-inflammatory diseases (2021)
  • Author(s): Matsumoto Tatsuaki、Sato Yuiko、Kobayashi Tami、Ito Eri、Soma Tomoya、Kimura Atsushi、Miyamoto Kana、Kobayashi Shu、Harato Kengo、Matsumoto Morio、Nakamura Masaya、Niki Yasuo、Miyamoto Takeshi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 558 Pages: 183-188
  • DOI: 10.1016/j.bbrc.2021.04.093
  • Peer Reviewed
• [Journal Article] Overexpression of Interleukin-1α Suppresses Liver Metastasis of Lymphoma: Implications for Antitumor Effects of CD8+ T-cells (2021)
  • Author(s): Udagawa K, Niki Y, Kikuchi T, Fukuhara Y, Takeda Y, Miyamoto T, Matsumoto M, Nakamura M
  • Journal Title: J Histochem Cytochem Volume: 69 Issue: 4 Pages: 245-255
  • DOI: 10.1369/0022155421991634
  • Peer Reviewed
• [Presentation] 骨代謝の基礎的な理解に基づく骨粗鬆症の治療戦略 -新たな骨形成促進薬の登場を踏まえて- (2024)
  • Author(s): 宮本健史
  • Organizer: 第64回関東整形災害外科学会
  • Invited
• [Presentation] 大腿骨近位部骨折に関する調査研究成果について (2024)
  • Author(s): 宮本健史
  • Organizer: 熊本地域リハビリテーション支援協議会研修会
  • Invited
• [Presentation] 性ホルモンと骨粗鬆症 (2024)
  • Author(s): 宮本健史
  • Organizer: 日本抗加齢医学会専門医・指導士認定委員会講習会
  • Invited
• [Presentation] 骨代謝と骨粗鬆症 (2024)
  • Author(s): 宮本健史
  • Organizer: 第8回日本骨免疫学会冬季学術集会
  • Invited
• [Presentation] 関節リウマチ治療におけるステロイドの功罪 (2023)
  • Author(s): 宮本健史
  • Organizer: 令和5年度九州・沖縄地区リウマチの治療とケア教育研修会
  • Invited
• [Presentation] 関節リウマチの病態の理解に基づく治療戦略 (2023)
  • Author(s): 宮本健史
  • Organizer: 第117回奈良県医師会整形外科部会・教育研修講演会
  • Invited
• [Presentation] 骨粗鬆症の病態の理解と治療戦略 -大腿骨近位部骨折予防を含めて- (2023)
  • Author(s): 宮本健史
  • Organizer: 第50回日本股関節学会
  • Invited
• [Presentation] 骨粗鬆症Up to date (2023)
  • Author(s): 宮本健史
  • Organizer: 熊本県医師会医学講座2023
  • Invited
• [Presentation] 骨粗鬆症とロコモティブシンドローム (2023)
  • Author(s): 宮本健史
  • Organizer: 骨と関節の日「県民のための公開講座」
  • Invited
• [Presentation] 骨移植 -骨って移植できるの？- (2023)
  • Author(s): 宮本健史
  • Organizer: 移植医療市民公開講座2023
  • Invited
• [Presentation] 骨粗鬆症の病態の理解と新たな活性型ビタミンD製剤の可能性 (2023)
  • Author(s): 宮本健史
  • Organizer: 第41回日本骨代謝学会学術集会
  • Invited
• [Presentation] 骨粗鬆症とリハビリテーション医学 (2023)
  • Author(s): 宮本健史
  • Organizer: 第60回日本リハビリテーション医学会学術集会
  • Invited
• [Presentation] 骨代謝と骨粗鬆症 (2023)
  • Author(s): 宮本健史
  • Organizer: 第8回日本骨免疫学会
  • Invited
• [Presentation] 破骨細胞からの骨代謝 (2023)
  • Author(s): 宮本健史
  • Organizer: 第8回日本骨免疫学会
  • Invited
• [Presentation] 骨代謝の基礎的な理解に基づく骨粗鬆症の治療戦略～新たな骨形成促進薬の登場を踏まえて～ (2023)
  • Author(s): 宮本健史
  • Organizer: 第46回日本骨・関節感染症学会
  • Invited
• [Presentation] 性ホルモンと骨粗鬆症 (2023)
  • Author(s): 宮本健史
  • Organizer: 第23回日本抗加齢医学会総会
  • Invited
• [Presentation] 整形外科専門医制度の現状と問題点 シーリング設定県における整形外科専門医プログラム (2023)
  • Author(s): 宮本健史
  • Organizer: 第96回日本整形外科学会学術集会
  • Invited
• [Presentation] IL-6-STAT3を介した関節炎・関節破壊の慢性化機構 (2023)
  • Author(s): 宮本健史
  • Organizer: 第65回九州リウマチ学会
  • Invited
• [Presentation] 骨粗鬆症の病態と治療 (2022)
  • Author(s): 宮本健史
  • Organizer: 第399回日本内科学会九州地方会
  • Invited
• [Presentation] 病態の理解に基づいた骨粗鬆症治療 大腿骨近位部骨折二次骨折予防に関する診療報酬改定を含めて (2022)
  • Author(s): 宮本健史
  • Organizer: 第144回西日本整形・災害外科学術集会
  • Invited
• [Presentation] 関節リウマチの病態の解明と治療標的の同定―フィルゴチニブのポテンシャル― (2022)
  • Author(s): 宮本健史
  • Organizer: 第37回日本整形外科学会基礎学術集会
  • Invited
• [Presentation] 性ホルモンと骨粗鬆症 (2022)
  • Author(s): 宮本健史
  • Organizer: 第42回日本骨形態計測学会
  • Invited
• [Presentation] 最近の骨粗鬆症治療と骨粗鬆症のリスク (2022)
  • Author(s): 宮本健史
  • Organizer: 第７回日本骨免疫学会
  • Invited
• [Presentation] IL-6と骨免疫 (2022)
  • Author(s): 宮本健史
  • Organizer: 第７回日本骨免疫学会
  • Invited
• [Presentation] Osteoporosis: From Bench to Bedside (2022)
  • Author(s): Takeshi Miyamoto
  • Organizer: The 10th Seoul Symposium on Bone Health & The 34th Spring Scientific Congress of the Korean Society for Bone and Mineral Research
  • Int'l Joint Research / Invited
• [Presentation] Osteoporosis: Bench to Bedside (2022)
  • Author(s): Takeshi Miyamoto
  • Organizer: 9.The 95th Annual Meeting of the Japanese Orthopaedic Association
  • Invited
• [Presentation] サルコペニアと筋萎縮（骨粗鬆症を交えて） (2022)
  • Author(s): 宮本健史
  • Organizer: 第51回日本脊椎脊髄病学会
• [Presentation] 骨リモデリング作用による脆弱性骨折予防を目的とした骨粗鬆症治療 (2022)
  • Author(s): 宮本健史
  • Organizer: 第51回日本脊椎脊髄病学会
  • Invited
• [Presentation] 慢性炎症と関節破壊とIL-6 (2022)
  • Author(s): 宮本健史
  • Organizer: 第34回日本軟骨代謝学会
• [Presentation] 超高齢社会における腰痛診療 腰痛と超高齢社会における骨粗鬆症治療 (2021)
  • Author(s): 宮本健史
  • Organizer: 第29回日本腰痛学会
• [Presentation] 骨粗鬆症の検査と治療 (2021)
  • Author(s): 宮本健史
  • Organizer: 第49回日本放射線技術学会秋季学術大会
• [Presentation] 関節リウマチの関節破壊メカニズムと治療アプローチ (2021)
  • Author(s): 宮本健史
  • Organizer: 第36回日本整形外科学会基礎学術集会
• [Presentation] 関節リウマチにおける関節破壊機序とその制御 (2021)
  • Author(s): 宮本健史
  • Organizer: 第39回日本骨代謝学会
• [Presentation] サルコペニアと骨粗鬆症の発症を予測するバイオマーカー同定の試み (2021)
  • Author(s): 宮本健史
  • Organizer: 第23回日本骨粗鬆症学会
• [Presentation] 簡易脳波測定器を用いた疼痛の評価と機械学習による識別 (2021)
  • Author(s): 宮本健史
  • Organizer: 第50回日本リハビリテーション医学会・九州地方会
• [Presentation] 運動と骨 疲労骨折を中心に (2021)
  • Author(s): 宮本健史
  • Organizer: 第41回日本骨形態計測学会