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Bone substitute material with high osteoconductivity and elasticity

Research Project

Project/Area Number 21H03121
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 57040:Regenerative dentistry and dental engineering-related
Research InstitutionTohoku University

Principal Investigator

Suzuki Osamu  東北大学, 歯学研究科, 教授 (60374948)

Co-Investigator(Kenkyū-buntansha) 濱井 瞭  東北大学, 歯学研究科, 助教 (00824004)
森 優  東北大学, 大学病院, 講師 (70634541)
塩飽 由香利  東北大学, 歯学研究科, 大学院非常勤講師 (80736190)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2023: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2022: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2021: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Keywords骨再生 / 骨補填材 / 骨伝導 / 力学的性質
Outline of Research at the Start

本研究では,gelatin(Gel)分子が再線維化して弾性化が期待できるペプチド分子を導入し,リン酸八カルシウム(OCP)のクラスターを合成して,高弾性かつ骨再生能を持つOCP骨補填材の創製を目指す.天然骨はcollagen(Col)とハイドロキシアパタイト(HA)ナノ結晶の絡み合いにより優れた力学特性を獲得している.天然骨の海綿骨にアプローチする高弾性を示すOCP骨補填材を得るために,OCPの不均一核生成を誘起可能なGel分子を基材に用い,Gelの再線維化およびOCPクラスター核生成を誘導し,その上で溶液過飽和度調節法による結晶間の成長・絡み合いを実現することで,OCP骨補填材の高弾性化が可能となるか実証する.

Outline of Final Research Achievements

The present study suggested that octacalcium phosphate (OCP) enhances accumulation of mesenchymal stem cells (MSCs), osteoblast and osteocyte differentiations; 2)matrix material gelatin (Gel) produces degradation products upon dissolution, which stimulates angiogenesis; 3) a composite OCP/Gel showed that cortical bone can be regenerated by its implanting into a transcortical bone defect in rat long bone, and 4) that co-precipitation of Gel molecules and OCP promotes new bone formation by introducing lattice defects in OCP. These results suggest that the combined use of OCP and Gel may lead to the establishment of a material design guideline for bone substitute materials used under the load environments.

Academic Significance and Societal Importance of the Research Achievements

リン酸カルシウム材料の中で,OCPは骨伝導を示す材料であるが,課題として焼成プロセスによる単一結晶相の成形は困難であること,そのため生体由来高分子と複合化して賦形性,機械的性質を向上させる必要があることがあげられる.本研究では,OCP自体が示す間葉系幹細胞についての細胞活性化能,基質材料となるGelとの複合化を想定し,Gel自体の血管新生能,OCPとgelatin分子の共沈殿による結晶性状への影響,OCP/Gelの長管骨骨欠損の皮質骨再生能を明らかにした.本研究の結果は,OCPとGelとの併用が荷重下環境となる長管骨での骨再生に使い得る新たな骨補填材の設計指針の確立につながることが示唆された.

Report

(3 results)
  • 2023 Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (15 results)

All 2022 2021 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 4 results,  Invited: 5 results) Book (1 results) Remarks (4 results)

  • [Journal Article] Octacalcium Phosphate/Gelatin Composite (OCP/Gel) Enhances Bone Repair in a Critical-sized Transcortical Femoral Defect Rat Model2022

    • Author(s)
      Hamada Soshi、Mori Yu、Shiwaku Yukari、Hamai Ryo、Tsuchiya Kaori、Baba Kazuyoshi、Oizumi Itsuki、Kanabuchi Ryuichi、Miyatake Naohisa、Aizawa Toshimi、Suzuki Osamu
    • Journal Title

      Clinical Orthopaedics & Related Research

      Volume: 480 Issue: 10 Pages: 2043-2055

    • DOI

      10.1097/corr.0000000000002257

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation of committed osteoblast progenitors by octacalcium phosphate compared to calcium-deficient hydroxyapatite in Lepr-cre/Tomato mouse tibia2022

    • Author(s)
      Okuyama Kyosuke、Shiwaku Yukari、Hamai Ryo、Mizoguchi Toshihide、Tsuchiya Kaori、Takahashi Tetsu、Suzuki Osamu
    • Journal Title

      Acta Biomaterialia

      Volume: 142 Pages: 332-344

    • DOI

      10.1016/j.actbio.2022.02.016

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Octacalcium phosphate crystals including a higher density dislocation improve its materials osteogenecity2022

    • Author(s)
      Hamai Ryo、Sakai Susumu、Shiwaku Yukari、Anada Takahisa、Tsuchiya Kaori、Ishimoto Takuya、Nakano Takayoshi、Suzuki Osamu
    • Journal Title

      Applied Materials Today

      Volume: 26 Pages: 101279-101279

    • DOI

      10.1016/j.apmt.2021.101279

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of distant octacalcium phosphate scaffolds in enhancing early differentiation of osteocytes during bone regeneration.2021

    • Author(s)
      Saito S., Shiwaku Y., Hamai R., Hasegawa T., Sakai S., Tsuchiya K., Sai Y., Iwama R., Amizuka N., Takahashi T., Suzuki O.
    • Journal Title

      Acta Biomaterialia

      Volume: 129巻 Pages: 309-322

    • DOI

      10.1016/j.actbio.2021.05.017

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of simultaneous hydrolysis of OCP and PLGA on bone induction of a PLGA-OCP composite scaffold in a rat femoral defect2021

    • Author(s)
      Oizumi Itsuki、Hamai Ryo、Shiwaku Yukari、Mori Yu、Anada Takahisa、Baba Kazuyoshi、Miyatake Naohisa、Hamada Soshi、Tsuchiya Kaori、Nishimura Shin-nosuke、Itoi Eiji、Suzuki Osamu
    • Journal Title

      Acta Biomaterialia

      Volume: 124 Pages: 358-373

    • DOI

      10.1016/j.actbio.2021.01.048

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Presentation] A bioactive bone substitute material simulating bone apatite mineral precursor2022

    • Author(s)
      Osamu Suzuki
    • Organizer
      Forsyth Institute Thursday Seminar 2022, Cambridge, MA, USA (Online)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Octacalcium phosphate biomaterials: Applicability for hard tissue and related tissue regenerations as a defect filling material2022

    • Author(s)
      Osamu Suzuki
    • Organizer
      International Dental Materials Congress 2022 (IDMC2022), Taipei, Taiwan (Online)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of octacalcium phosphate on enhancing osteocyte differentiation during orthotopic bone regeneration2022

    • Author(s)
      Osamu Suzuki
    • Organizer
      2022 JSB/SFB Joint Symposium (Online)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Bioactive performance of octacalcium phosphate and its composite materials2021

    • Author(s)
      Osamu Suzuki
    • Organizer
      第69回JADR学術大会シンポジウム,"Japan-Originated Next Generation Biomedical Materials"
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Bioactive bone substitute materials involving conversion into bone-like tissues2021

    • Author(s)
      Osamu Suzuki
    • Organizer
      The 6th International Symposium on Biomedical Engineering (ISBE2021)(第6回生体医歯工学共同研究拠点国際シンポジウム)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] バイオマテリアル-生体材料2022

    • Author(s)
      鈴木 治,濱井 瞭,塩飽由香利
    • Total Pages
      9
    • Publisher
      日本バイオマテリアル学会(田中昭文堂印刷株式会社)
    • Related Report
      2022 Annual Research Report
  • [Remarks] 東北大学大学院歯学研究科 顎口腔機能創建学分野HP

    • URL

      https://www.dent.tohoku.ac.jp/field/maxillofacial/02/index.html

    • Related Report
      2022 Annual Research Report
  • [Remarks] 東北大学大学院歯学研究科 顎口腔機能創建学分野研究室HP

    • URL

      https://www.cfe.dent.tohoku.ac.jp/

    • Related Report
      2022 Annual Research Report
  • [Remarks] 東北大学大学院歯学研究科顎口腔機能創建学分野HP

    • URL

      https://www.cfe.dent.tohoku.ac.jp/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 東北大学大学院歯学研究科・歯学部HP

    • URL

      http://www.dent.tohoku.ac.jp/field/maxillofacial/02/index.html

    • Related Report
      2021 Annual Research Report

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Published: 2021-04-28   Modified: 2025-01-30  

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