Establishing Evidence for Extending Healthy Life Expectancy by Maintaining Oral Function: A 12-Year Cohort Study of 2600 Old People

• Project/Area Number: 21H03130
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Osaka University
• Principal Investigator: Ikebe Kazunori 大阪大学, 大学院歯学研究科, 教授 (70273696)
• Co-Investigator(Kenkyū-buntansha): 尾形 宗士郎 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (00805012) ; 八田 昂大 大阪大学, 大学院歯学研究科, 招へい教員 (60845949) ; 福武 元良 大阪大学, 歯学部附属病院, 医員 (10883259)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2023: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2022: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2021: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
• Keywords: 口腔機能 / 高齢者 / 大規模コホート / 健康長寿 / 栄養状態 / 認知機能 / 運動機能

Outline of Research at the Start

歯の状態，口腔機能，歯科補綴治療とそれに伴う食品摂取の変化が，低栄養，生活習慣病の発症や認知機能，筋力や運動機能低下（サルコペニア・フレイルなど）などに与える影響を，自立した生活を送っていた70歳以上の約2600名を対象に，12年間の前向きコホート研究で明らかにする．

Outline of Final Research Achievements

This study aimed to investigate the association between oral function and the extension of healthy life expectancy using up to 12 years of longitudinal data obtained from a large cohort of community-dwelling older adults. The multilevel analysis revealed the following findings: (1) The baseline state of posterior occlusal support and its decline influenced the deterioration of masticatory performance six years later, (2) High masticatory performance suppressed the onset of psychological frailty even after adjusting for background factors, and (3) The number of teeth was significantly associated with the intake of meat and green and yellow vegetables, and there was a longitudinal association between these factors and cognitive function.

Academic Significance and Societal Importance of the Research Achievements

本研究結果より，歯数や咀嚼能率といった口腔機能の維持は，高齢者の健康寿命の延伸に寄与することが示唆された．信頼性の高い客観的な機能検査に基づく大規模な長期コホート研究から得られたこれらの知見は，口腔機能が心身の健康に及ぼす影響について，質の高いエビデンスを提供するものである。

Research Products

• [Journal Article] Relationship between occlusal force and psychological frailty in Japanese community‐dwelling older adults: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study (2023)
  • Author(s): Akema Suzuna、Mameno Tomoaki、Nakagawa Takeshi、Inagaki Hiroki、Fukutake Motoyoshi、Hatta Kodai、Murotani Yuki、Tsujioka Yoshitaka、Hagino Hiromasa、Higashi Kotaro、Takahashi Toshihito、Wada Masahiro、Maeda Yoshinobu、Gondo Yasuyuki、Kamide Kei、Kabayama Mai、Ishizaki Tatsuro、Masui Yukie、Ogata Soshiro、Ikebe Kazunori
  • Journal Title: Journal of the American Geriatrics Society Volume: - Issue: 6 Pages: 1819-1828
  • DOI: 10.1111/jgs.18239
  • Peer Reviewed
• [Journal Article] The relationship between changes in occlusal support and masticatory performance using 6-year longitudinal data from the SONIC study (2023)
  • Author(s): Higashi K, Hatta K, Mameno T, Takahashi T, Gondo Y, Kamide K, Masui Y, Ishizaki T, Arai Y, Kabayama M, Nishimura Y, Murotani Y, Hagino H, Tsujioka Y, Akema S, Maeda E, Seto E, Okada Y, Mihara Y, Wada M, Maeda Y, Ikebe K
  • Journal Title: Journal of Dentistry Volume: 139 Pages: 104763-104763
  • DOI: 10.1016/j.jdent.2023.104763
  • Peer Reviewed / Open Access
• [Journal Article] Construct Validity of a New Health Assessment Questionnaire for the National Screening Program of Older Adults in Japan: The SONIC Study. (2022)
  • Author(s): Ishizaki T, Masui Y, Nakagawa T, Yoshida Y, Ishioka YL, Hori N, Inagaki H, Ito K, Ogawa M, Kabayama M, Kamide K, Ikebe K, Arai Y, Gondo Y.
  • Journal Title: Int J Environ Res Public Health Volume: 19 Issue: 16 Pages: 10330-10330
  • DOI: 10.3390/ijerph191610330
  • Peer Reviewed / Open Access
• [Journal Article] Associations between salivary testosterone levels and cognitive function among 70‐year‐old Japanese elderly: A cross‐sectional analysis of the <scp>SONIC</scp> study (2022)
  • Author(s): Hirokawa Kumi、Kasuga Ayaka、Matsumoto Kiyoaki、Omori Yasuko、Masui Yukie、Nakagawa Takeshi、Ogawa Madoka、Ishioka Yoshiko、Inagaki Hiroki、Ikebe Kazunori、Arai Yasumichi、Ishizaki Tatsuro、Kamide Kei、Gondo Yasuyuki
  • Journal Title: Geriatrics &amp; Gerontology International Volume: 22 Issue: 12 Pages: 1040-1046
  • DOI: 10.1111/ggi.14504
  • Peer Reviewed / Open Access
• [Presentation] 咀嚼能率と心理的フレイル発症との関連の検討 ６年間の前向きコホート研究 (2023)
  • Author(s): 明間すずな，豆野智昭，高橋利士，八田昂大，和田誠大，室谷有紀，萩野弘将，辻岡義祟，東孝太郎，瀬戸英里，岡田佳恵，池邉一典
  • Organizer: 日本補綴歯科学会 第132回学術大会
• [Presentation] Masticatory performance indicates the development of psychological frailty (2023)
  • Author(s): Akema S, Mameno T, Wada M, Takahashi T, Kosaka T, Mihara Y, Higashi K, Tsujioka Y, Seto E, Okada Y, Ikebe K
  • Organizer: ECG Annual Congress Stockholm 2023
  • Int'l Joint Research
• [Presentation] Decrease in posterior occlusal support affects the progression of atherosclerosis among community-dwelling older adults (2023)
  • Author(s): Seto E, Kosaka T, Kamide K, Gondo Y, Kabayama M, Godai K, Kido M, Akasaka H, Yamamoto K, Ishizaki T, Arai Y, Masui Y, Takahashi T, Mameno T, Mihara Y, Murotani Y, Tsujioka Y, Akema S, Okada Y, Ikebe K
  • Organizer: ECG Annual Congress Stockholm 2023
  • Int'l Joint Research
• [Presentation] 地域在住高齢者における口腔機能と握力との関連─構造方程式モデリングを用いた検討─ (2022)
  • Author(s): 明間すずな，豆野智昭，八田昂大，高橋利士，和田誠大，室谷有紀，辻岡義祟，権藤恭之，神出計，樺山舞，杉本研，楽木宏実，石崎達郎，増井幸恵，池邉一典
  • Organizer: 日本サルコペニアフレイル学会 第9回学術大会
• [Presentation] Relationship between maximum occlusal force and psychological frailty (2022)
  • Author(s): Akema S, Mameno T, Fukutake M, Hatta K, Murotani Y, Hagino H, Higashi K, Tsujioka Y, Wada M, Takahashi T, Ikebe K
  • Organizer: The 100th General Session & Exhibition of the International Association for Dental Research
  • Int'l Joint Research
• [Presentation] 臼歯部咬合支持の喪失と咀嚼能力との関連 ―SONIC研究6年間の縦断データより― (2022)
  • Author(s): 東孝太郎，八田昂大，高橋利士，豆野智昭，福武元良，西村優一，室谷有紀，萩野弘将，辻岡義崇，前田絵里紗，明間すずな，三原佑介，和田誠大，前田芳信，池邉一典
  • Organizer: 日本補綴歯科学会 第131回学術大会
• [Presentation] Relationship between maximum occlusal force and psychological frailty (2022)
  • Author(s): Akema S, Mameno T, Fukutake M, Hatta K, Murotani Y, Hagino H, Higashi K, Tsujioka Y, Wada M, Takahashi T, Ikebe K
  • Organizer: The International Association for Dental Research 100th General Session & Exhibition
• [Presentation] 地域在住高齢者における心理的フレイルと咬合力との関連の検討 (2022)
  • Author(s): 明間すずな，豆野智昭，高橋利士，八田昂大，福武元良，西村優一，室谷有紀，萩野弘将，辻岡義祟，三原佑介，和田誠大，池邉一典
  • Organizer: 第33回日本老年歯科医学会学術大会