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Understanding of the relationship between skeletal muscle and cancer for regulating muscle invasion of oral squamous cell carcinoma

Research Project

Project/Area Number 21H03144
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 57060:Surgical dentistry-related
Research InstitutionKyushu Dental College

Principal Investigator

Kokabu Shoichiro  九州歯科大学, 歯学部, 教授 (30448899)

Co-Investigator(Kenkyū-buntansha) 土生 学  九州歯科大学, 歯学部, 講師 (00360058)
Addison William  九州歯科大学, 歯学部, 講師 (40845046)
佐藤 毅  九州歯科大学, 歯学部, 教授 (60406494)
矢田 直美  九州歯科大学, 歯学部, 准教授 (60468022)
細見 周平  大阪公立大学, 大学院医学研究科, 講師 (60554938)
永野 健一  長崎大学, 医歯薬学総合研究科(歯学系), 助教 (60834348)
中平 光彦  埼玉医科大学, 医学部, 教授 (10253353)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2023: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2022: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2021: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Keywords舌筋 / 舌がん / 口腔扁平上皮がん / リンパ節転移 / 筋再生 / 舌筋再生 / シングルセルRNA-seq / 扁平上皮がん / DKK-1 / 骨格筋 / 骨 / 炎症 / がん筋層浸潤
Outline of Research at the Start

舌がんは粘膜下の筋層に浸潤すると予後が悪い.そのためがん細胞の筋層浸潤の制御は重要な課題であるが,そのメカニズム,特に宿主側の筋と浸潤するがん細胞との関連(がん・骨格筋連関)には不明な点が多い.本研究では,舌扁平上皮がんの新規バイオマーカーと新規治療法の確立を最終ゴールとし,実際の口腔扁平上皮がん、咽喉頭扁平上皮がん、食道扁平上皮がん患者の検体から、筋層浸潤のリスクファクターを同定する. さらに培養細胞とマウスを用いた実験から扁平上皮がんの筋層浸潤メカニズムの解明を試みる.

Outline of Final Research Achievements

Since invasion to tongue muscle layer of cancer cells worsens the prognosis, it is important to elucidate and control this process. Therefore, we focused on the fact that the tongue muscle breaks, and the regeneration occurs during cancer cell invasion. To understand the process of tongue muscle regeneration, we firstly established a method to isolate highly pure tongue muscle stem cells. We also compared the regeneration process of tongue muscle induced by CTX injection with that of tibialis anterior muscle and found differences in the expression pattern of homeobox genes. In addition, we are currently comparing the regeneration process of the tongue muscle in young and aged mice by single-cell RNA-seq and histological analysis. Studies using clinical specimens from patients with tongue squamous cell carcinoma suggest that DKK1 and CKAP4 expression may be predictors of lymph node metastasis.

Academic Significance and Societal Importance of the Research Achievements

宿主側の要因はがん治療に対する反応性や予後に確実に関連するにもかかわらず,現状では宿主要因に着目したエビデンスのレベルの高い研究は少なかった.今回われわれは舌扁平上皮がんにおいて,がんの浸潤する際に,宿主側の舌筋が破壊し,舌筋の再生機転に入ることを突き止めた.さらに,今後の研究から,舌扁平上皮がん組織におけるDKK1タンパク質とCKAP4タンパク質のダブルポジティブが,リンパ節転移の予測因子となることが決定できれば,口腔がん医療に対する貢献は計り知れない.

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (64 results)

All 2024 2023 2022 2021 Other

All Int'l Joint Research (1 results) Journal Article (26 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 26 results,  Open Access: 17 results) Presentation (37 results) (of which Int'l Joint Research: 11 results,  Invited: 1 results)

  • [Int'l Joint Research] ボルドー大学(フランス)

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Royal Jelly Enhances the Ability of Myoblast C2C12 Cells to Differentiate into Multilineage Cells2024

    • Author(s)
      Ito Takumi、Rojasawasthien Thira、Takeuchi Sachiko Yamashita、Okamoto Hideto、Okumura Nobuaki、Shirakawa Tomohiko、Matsubara Takuma、Kawamoto Tatsuo、Kokabu Shoichiro
    • Journal Title

      Molecules

      Volume: 29 Issue: 7 Pages: 1449-1449

    • DOI

      10.3390/molecules29071449

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The importance of taste on swallowing function2024

    • Author(s)
      Okubo Masahiko、Morishita Motoyoshi、Odani Tomoko、Sakaguchi Hideo、Kikutani Takeshi、Kokabu Shoichiro
    • Journal Title

      Frontiers in Nutrition

      Volume: 11

    • DOI

      10.3389/fnut.2024.1356165

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bioactive gelatin-sheets as novel biopapers to support prevascularization organized by laser-assisted bioprinting for bone tissue engineering2024

    • Author(s)
      Kerouredan Olivia、Washio Ayako、Handschin Charles、Devillard Raphael、Kokabu Shoichiro、Kitamura Chiaki、Tabata Yasuhiko
    • Journal Title

      Biomedical Materials

      Volume: 19 Issue: 2 Pages: 025038-025038

    • DOI

      10.1088/1748-605x/ad270a

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of Bioactive Glasses and Basic Fibroblast Growth Factor on Dental Pulp Cells2023

    • Author(s)
      Washio Ayako、Kerouredan Olivia、Tabata Yasuhiko、Kokabu Shoichiro、Kitamura Chiaki
    • Journal Title

      Journal of Functional Biomaterials

      Volume: 14 Issue: 12 Pages: 568-568

    • DOI

      10.3390/jfb14120568

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Weaning from Tube Feeding Post Stroke by Eating, Swallowing, and Nutritional Support In-Home2023

    • Author(s)
      Inayama Miku、Goto Tomoyuki、Kokabu Shoichiro、Okubo Masahiko
    • Journal Title

      Home Healthcare Now

      Volume: 41 Issue: 4 Pages: 221-225

    • DOI

      10.1097/nhh.0000000000001173

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Slow starch hydrolysis of non-glutinous rice flour and potato starch heated with taxifolin: contribution of proteins to the former and longer amylose to the latter2023

    • Author(s)
      Takahama Umeo、Yanase Emiko、Kokabu Shoichiro、Ansai Toshihiro、Hirota Sachiko
    • Journal Title

      International Journal of Food Sciences and Nutrition

      Volume: 74 Issue: 4 Pages: 463-475

    • DOI

      10.1080/09637486.2023.2220987

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hepcidin expression in the trigeminal ganglion and the oral mucosa in an oral ulcerative mucositis rat model2023

    • Author(s)
      Hitomi Suzuro、Nodai Tomotaka、Kokabu Shoichiro、Shikayama Takemi、Sago-Ito Misa、Nakatomi Chihiro、Terawaki Kiyoshi、Omiya Yuji、Shinoda Masamichi、Ono Kentaro
    • Journal Title

      PLOS ONE

      Volume: 18 Issue: 4 Pages: 0284617-0284617

    • DOI

      10.1371/journal.pone.0284617

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nutritional Management in a 101-Year-Old Woman with Physical Inactivity and General Weakness: A Case Report2023

    • Author(s)
      Mineyama Ryoko、Tezuka Fumie、Takagi Nobuko、Kokabu Shoichiro、Okubo Masahiko
    • Journal Title

      Geriatrics

      Volume: 8 Issue: 1 Pages: 8-8

    • DOI

      10.3390/geriatrics8010008

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nobiletin, a <scp>NF‐κB</scp> signaling antagonist, promotes <scp>BMP</scp> ‐induced bone formation2022

    • Author(s)
      Rojasawasthien Thira、Usui Michihiko、Addison William N.、Matsubara Takuma、Shirakawa Tomohiko、Tsujisawa Toshiyuki、Nakashima Keisuke、Kokabu Shoichiro
    • Journal Title

      FASEB BioAdvances

      Volume: 5 Issue: 2 Pages: 62-70

    • DOI

      10.1096/fba.2022-00093

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plectin promotes tumor formation by B16 mouse melanoma cells via regulation of Rous sarcoma oncogene activity2022

    • Author(s)
      Mizuta Kana、Matsubara Takuma、Goto Akino、Addison William N.、Nakatomi Mitsushiro、Matsuo Kou、Tada-Shigeyama Yukiyo、Yaginuma Tatsuki、Honda Hiromi、Yoshioka Izumi、Kokabu Shoichiro
    • Journal Title

      BMC Cancer

      Volume: 22 Issue: 1 Pages: 1-13

    • DOI

      10.1186/s12885-022-10033-4

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tyrosine Kinase Src Is a Regulatory Factor of Bone Homeostasis2022

    • Author(s)
      Matsubara Takuma、Yasuda Kazuma、Mizuta Kana、Kawaue Hiroka、Kokabu Shoichiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 10 Pages: 5508-5508

    • DOI

      10.3390/ijms23105508

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Case of Necrotizing Periodontitis in a Care-Requiring Elderly Person Treated and Managed by Interprofessional Collaboration2022

    • Author(s)
      Okubo Masahiko、Kuraji Ryutaro、Kamimura Hideyuki、Numabe Yukihiro、Ito Ko、Sato Tsuyoshi、Kokabu Shoichiro
    • Journal Title

      Dentistry Journal

      Volume: 10 Issue: 5 Pages: 79-79

    • DOI

      10.3390/dj10050079

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Factors Regulating or Regulated by Myogenic Regulatory Factors in Skeletal Muscle Stem Cells2022

    • Author(s)
      Shirakawa Tomohiko、Toyono Takashi、Inoue Asako、Matsubara Takuma、Kawamoto Tatsuo、Kokabu Shoichiro
    • Journal Title

      Cells

      Volume: 11 Issue: 9 Pages: 1493-1493

    • DOI

      10.3390/cells11091493

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Case of Drastic Reduction of Membranous Substances in the Pharynx by Interprofessional Cooperative Oral Care2022

    • Author(s)
      Okubo Masahiko、Kamimura Hideyuki、Sato Tsuyoshi、Kokabu Shoichiro
    • Journal Title

      Case Reports in Dentistry

      Volume: 2022 Issue: 1 Pages: 1-4

    • DOI

      10.1155/2022/6375915

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tongue Muscle for the Analysis of Head Muscle Regeneration Dynamics2022

    • Author(s)
      Goto A.、Kokabu S.、Dusadeemeelap C.、Kawaue H.、Matsubara T.、Tominaga K.、Addison W.N.
    • Journal Title

      Journal of Dental Research

      Volume: 101 Issue: 8 Pages: 962-971

    • DOI

      10.1177/00220345221075966

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of TET‐mediated DNA demethylation suppresses osteoblast differentiation2022

    • Author(s)
      Dusadeemeelap Chirada、Rojasawasthien Thira、Matsubara Takuma、Kokabu Shoichiro、Addison William N.
    • Journal Title

      The FASEB Journal

      Volume: 36 Issue: 2 Pages: 1-17

    • DOI

      10.1096/fj.202101402r

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of alveolar bone destruction in periodontitis ? Periodontal bacteria and inflammation2021

    • Author(s)
      Usui Michihiko、Onizuka Satoru、Sato Tsuyoshi、Kokabu Shoichiro、Ariyoshi Wataru、Nakashima Keisuke
    • Journal Title

      Japanese Dental Science Review

      Volume: 57 Pages: 201-208

    • DOI

      10.1016/j.jdsr.2021.09.005

    • NAID

      210000173382

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor necrosis factor alpha regulates myogenesis to inhibit differentiation and promote proliferation in satellite cells2021

    • Author(s)
      Shirakawa Tomohiko、Rojasawasthien Thira、Inoue Asako、Matsubara Takuma、Kawamoto Tatsuo、Kokabu Shoichiro
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 580 Pages: 35-40

    • DOI

      10.1016/j.bbrc.2021.09.067

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myogenic differentiation 1 and transcription factor 12 activate the gene expression of mouse taste receptor type 1 member 12021

    • Author(s)
      Y. Obikane, T. Toyono, S. Kokabu, K. Matsuyama, S. Kataoka, M. Nakatomi, R. Hosokawa, Y. Seta
    • Journal Title

      J Oral Biosci

      Volume: 63 Issue: 4 Pages: 420-428

    • DOI

      10.1016/j.job.2021.08.005

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Case of Myxoma Arising in the Buccal Mucosa2021

    • Author(s)
      Okubo Masahiko、Sano Yoshie、Fukushima Yosuke、Tomoda Taketo、Kokabu Shoichiro、Sato Tsuyoshi
    • Journal Title

      Case Reports in Dentistry

      Volume: 2021 Pages: 1-3

    • DOI

      10.1155/2021/1358481

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protein phosphatase 1 regulatory subunit 18 suppresses the transcriptional activity of NFATc1 via regulation of c-fos2021

    • Author(s)
      Yasuda Kazuma、Matsubara Takuma、Shirakawa Tomohiko、Kawamoto Tatsuo、Kokabu Shoichiro
    • Journal Title

      Bone Reports

      Volume: 15 Pages: 101114-101114

    • DOI

      10.1016/j.bonr.2021.101114

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physicochemical Properties, Cytocompatibility, and Biocompatibility of a Bioactive Glass Based Retrograde Filling Material2021

    • Author(s)
      Murata Kazumasa、Washio Ayako、Morotomi Takahiko、Rojasawasthien Thira、Kokabu Shoichiro、Kitamura Chiaki
    • Journal Title

      Nanomaterials

      Volume: 11 Issue: 7 Pages: 1828-1828

    • DOI

      10.3390/nano11071828

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Natural Compounds Attenuate Denervation-Induced Skeletal Muscle Atrophy2021

    • Author(s)
      Shirakawa Tomohiko、Miyawaki Aki、Kawamoto Tatsuo、Kokabu Shoichiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 15 Pages: 8310-8310

    • DOI

      10.3390/ijms22158310

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of unique functionalities in c-Src domains required for osteoclast podosome belt formation2021

    • Author(s)
      Matsubara Takuma、Addison William N.、Kokabu Shoichiro、Neff Lynn、Horne William、Gori Francesca、Baron Roland
    • Journal Title

      Journal of Biological Chemistry

      Volume: 296 Pages: 100790-100790

    • DOI

      10.1016/j.jbc.2021.100790

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 原発性硬化性胆管炎患者に生じた持続性歯肉出血の1例2021

    • Author(s)
      久保 正彦, 福島 洋介, 林 直樹, 高久 裕紀, 小林 聖司, 川田 由美子, 伊藤 耕, 古株 彰一郎, 佐藤 毅
    • Journal Title

      有病者歯科医療

      Volume: 30 Pages: 297-301

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 全身麻酔下における下顎骨嚢胞摘出後に洞不全症候群と診断された1例2021

    • Author(s)
      大久保正彦, 林直樹, 古株彰一郎,福島洋介,川田由美子, 伊藤耕,佐藤毅
    • Journal Title

      有病者歯科医療

      Volume: 30 Pages: 421-425

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Presentation] Bioactive glassおよびbFGFで同時刺激したDental pulp cellsの解析2024

    • Author(s)
      鷲尾絢子、古株彰一郎、北村知昭、田畑泰彦
    • Organizer
      第23回日本再生医療学会総会、新潟
    • Related Report
      2023 Annual Research Report
  • [Presentation] KIF22, a gene associated with skeletal abnormalities in SEMDJL2 disease, is required for chondrocyte proliferation and differentiation2023

    • Author(s)
      Kawaue, H, Matsubara, T, Addison, W, Kokabu, S
    • Organizer
      29th IAPD congress, Maastricht, Netherland
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mapping the local protein interactome of PHEX in osteoblasts by proximity biotinylation2023

    • Author(s)
      Dusadeemeelap, C., Matsubara, T., Kokabu, S. Addison, W.
    • Organizer
      ASBMR 2023 Annual Meeting, Vancouver, Canada
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 味覚受容体T1R3は糖質を受容し破骨細胞分化を促進する2023

    • Author(s)
      吉村杏奈, 松原琢磨, 児玉奈央, 川元龍夫, 古株彰一郎
    • Organizer
      第18回九州矯正歯科学会学術大会, 長崎
    • Related Report
      2023 Annual Research Report
  • [Presentation] BMP-3bは骨量を負に制御する2023

    • Author(s)
      児玉奈央,松原 琢磨,田中 純平,吉賀大午,吉岡泉,古株彰一郎
    • Organizer
      第77回NPO法人日本口腔科学会学術集会,岡山
    • Related Report
      2023 Annual Research Report
  • [Presentation] ローヤルゼリーは骨格筋幹細胞の増殖・分化の制御を介して骨格筋の再生を促進する2023

    • Author(s)
      竹内(山下)紗智子,白川智彦,松原琢磨,古株彰一郎,川元龍夫
    • Organizer
      第82回九州歯科学会総会・学術大会,Web開催
    • Related Report
      2023 Annual Research Report
  • [Presentation] Slitrk1 は骨格筋再生の初期に必要である2023

    • Author(s)
      伊藤巧,白川智彦,松原琢磨,黒石加代子,郡司掛香織,川元龍夫,古株彰一郎
    • Organizer
      第82回九州歯科学会総会・学術大会,Web開催
    • Related Report
      2023 Annual Research Report
  • [Presentation] 味覚受容体T1R3は破骨細胞と骨芽細胞の分化を制御する2023

    • Author(s)
      吉村杏奈, 松原琢磨, 児玉奈央, 川元龍夫, 古株彰一郎
    • Organizer
      第82回九州歯科学会総会・学術大会,Web開催
    • Related Report
      2023 Annual Research Report
  • [Presentation] BMP-3bノックアウトマウスは高骨量を呈する2023

    • Author(s)
      児玉奈央,William N. Addison,松原 琢磨,吉賀 大午,吉岡 泉,古株 彰一郎
    • Organizer
      第82回九州歯科学会総会・学術大会,Web開催
    • Related Report
      2023 Annual Research Report
  • [Presentation] 味覚受容体T1R3による破骨細胞分化制御機構2023

    • Author(s)
      吉村杏奈, 松原琢磨, 児玉奈央, William Addison, 川元龍夫, 古株彰一郎
    • Organizer
      第41回日本骨代謝学会学術集会, 東京
    • Related Report
      2023 Annual Research Report
  • [Presentation] BMP-3bは骨芽細胞分化を制御し骨量を調節する2023

    • Author(s)
      児玉奈央, 松原 琢磨, William N. Addison, 古株彰一郎
    • Organizer
      第65回歯科基礎医学会学術大会,東京
    • Related Report
      2023 Annual Research Report
  • [Presentation] 味覚受容体T1R3は破骨細胞および骨芽細胞分化を制御する2023

    • Author(s)
      吉村杏奈, 松原琢磨, 川元龍夫, 古株彰一郎
    • Organizer
      第82回日本矯正歯科学会学術大会,新潟
    • Related Report
      2023 Annual Research Report
  • [Presentation] Slitrk1 nullマウスが形成する筋管は小さい2023

    • Author(s)
      伊藤巧,白川智彦,松原琢磨,黒石加代子,郡司掛香織,川元龍夫,古株彰一郎
    • Organizer
      第82回日本矯正歯科学会学術大会,新潟
    • Related Report
      2023 Annual Research Report
  • [Presentation] BMP-3bは骨芽細胞分化を制御し骨量を負に調節する2023

    • Author(s)
      児玉奈央, 松原 琢磨, 吉賀 大午, 吉岡 泉, 古株 彰一郎
    • Organizer
      第56回NPO法人日本口腔科学会九州地方部会,福岡
    • Related Report
      2023 Annual Research Report
  • [Presentation] 味覚受容体T1R3による破骨細胞および骨芽細胞分化制御機構2023

    • Author(s)
      吉村杏奈, 松原琢磨, 川元龍夫, 古株彰一郎
    • Organizer
      第19回九州矯正歯科学会学術大会,鹿児島
    • Related Report
      2023 Annual Research Report
  • [Presentation] evelopment and characterization of a novel biopaper incorporating bioactive glasses for vascularized bone biofabrication2023

    • Author(s)
      Kerouredan O, Washio A, Handschin C, Devillard R, Kokabu S, Kitamura C, tabata Y
    • Organizer
      Annual meeting for young researchers by French ARC Cancer Research Foundation
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] FGF2徐放性Bioactive glass配合gelatin spongeの生体適合性評価2023

    • Author(s)
      鷲尾絢子、矢田直美、古株彰一郎、北村知昭
    • Organizer
      第82回九州歯科学会総会・学術大会、Web開催
    • Related Report
      2023 Annual Research Report
  • [Presentation] Bioactive glass/bFGFで同時刺激した象牙芽細胞様細胞の解析2023

    • Author(s)
      鷲尾絢子、古株彰一郎、北村知昭、田畑泰彦
    • Organizer
      第45回日本バイオマテリアル学会大会、兵庫
    • Related Report
      2023 Annual Research Report
  • [Presentation] PPP1r18はc-fosのリン酸化の制御を介して破骨細胞分化を抑制する2022

    • Author(s)
      安田和真,松原琢磨,白川智彦,郡司掛香織,黒石加代子,川元龍夫,古株彰一郎
    • Organizer
      第17回九州矯正歯科学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] トゥレット症候群責任遺伝子の1つであるSlitrk1は正常な骨格筋再生に必要である2022

    • Author(s)
      伊藤巧,白川智彦,松原琢磨,黒石加代子,郡司掛香織,川元龍夫,古株彰一郎
    • Organizer
      第17回九州矯正歯科学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 骨格筋再生におけるプロテアーゼ処理ローヤルゼリーの効果2022

    • Author(s)
      井上愛沙子,伊藤巧,白川智彦,黒石加代子,郡司掛香織,水原正博,松原琢磨,古株彰一郎,川元龍夫
    • Organizer
      第17回九州矯正歯科学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] がん遺伝子Src結合分子Plectinは悪性黒色腫の増殖,移動および接着を制御する.2021

    • Author(s)
      水田 奏,松原 琢磨,後藤 晶乃,宮脇 有希,野島 淳也,佐藤 毅,柳沼 樹,吉賀 大午,冨永 和宏,吉岡 泉,古株 彰一郎
    • Organizer
      第75回NPO法人日本口腔科学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] c-fos制御を介したPPP1r18によるNFATc1転写活性抑制2021

    • Author(s)
      安田和真,松原琢磨, Addison William,川元龍夫,古株彰一郎
    • Organizer
      第80回九州歯科学会総会・学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 脊椎骨端骨幹端異形成-関節弛緩症の原因遺伝子KIF22は骨・軟骨に発現し細胞増殖を制御する2021

    • Author(s)
      川上 紘佳,松原 琢磨,Addison William,渡辺 幸嗣,牧 憲司,古株彰一郎
    • Organizer
      第80回九州歯科学会総会・学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Plectinはがん遺伝子Srcの活性化を介して悪性黒色腫の接着能を制御する2021

    • Author(s)
      水田 奏,松原 琢磨,Addison William,吉岡 泉,古株 彰一郎
    • Organizer
      第80回九州歯科学会総会・学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Plectinはがん遺伝子Srcの活性化を介して悪性黒色腫の接着能を制御する2021

    • Author(s)
      水田 奏,松原 琢磨,Addison William,吉岡 泉,古株 彰一郎
    • Organizer
      先端歯学スクール2022
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] ホスファターゼ調節因子PPP1r18はc-fosを脱リン酸化し破骨細胞分化を抑制する2021

    • Author(s)
      安田和真,松原琢磨,Addison William,白川智彦,郡司掛香織,黒石加代子,川元龍夫,古株彰一郎
    • Organizer
      第24回日本歯科医学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 破骨細胞分化過程においてPPP1r18はc-fosのリン酸化制御を通してNFATc1の転写活性を抑制する2021

    • Author(s)
      安田和真,松原琢磨,Addison William,川元龍夫,古株彰一郎
    • Organizer
      第39回日本骨代謝学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] うま味刺激でサルコペニアに挑戦する2021

    • Author(s)
      古株彰一郎
    • Organizer
      2021年度 日本味と匂学会 第55回大会(福岡)
    • Related Report
      2021 Annual Research Report
  • [Presentation] A phosphatase regulatory protein PPP1r18 inhibits NFATc1 activation and osteoclast differentiation via c-fos dephosphorylation2021

    • Author(s)
      Yasuda K, Matsubara T, Addison W, Kawamoto T, Kokabu S
    • Organizer
      Asia-Pacific Conference in Fukuoka 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nobiletin promotes osteoblast differentiation via suppressing NF-kB signaling2021

    • Author(s)
      Rojasawasthien T, Addison W, Matsubara T, Nakashima K, Kokabu S
    • Organizer
      Asia-Pacific Conference in Fukuoka 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] KIF22, a kinesin-like protein, is essential for cell proliferation in ATDC5 chondrocyte-like cells2021

    • Author(s)
      Kawaue H, Matsubara T, Addison W, Saeki K, Watanabe K, Maki K, Kokabu S
    • Organizer
      Asia-Pacific Conference in Fukuoka 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PLECTIN, a SRC oncogene-binding protein, promotes the growth and adhesion of malignant melanoma via regulation of SRC activity2021

    • Author(s)
      Mizuta K, Matsubara T, Addison, W., Yaginuma T, Yoshioka I, Kokabu S
    • Organizer
      Asia-Pacific Conference in Fukuoka 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ZBTB24 links multiple epigenetic pathways to mesenchymal progenitor differentiation2021

    • Author(s)
      Kokabu S, Inoue A, Matsubara T, Addison W
    • Organizer
      International Association of Dental Research (IADR) Annual Meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Oncogene Src binding protein Pectin control regulates growth of malignant melanoma by activation of oncogene Src2021

    • Author(s)
      Mizuta K, Matsubara T, Addison W, Yaginuma T, Yoshioka I, Kokabu S
    • Organizer
      International Association of Dental Research (IADR) Annual Meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment of a tongue muscle injury and regeneration model. International Association of Dental Research (IADR) Annual Meeting2021

    • Author(s)
      Goto A, Kawaue H, Matsubara T, Kokabu S, Tominaga K, Addison W
    • Organizer
      International Association of Dental Research (IADR) Annual Meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inhibition of TET-mediated DNA demethylation inhibits osteogenesis via Sp7 repression2021

    • Author(s)
      Chirada D, Rojasawasthien T, Matsubara T, Kokabu S, Addison W
    • Organizer
      International Association of Dental Research (IADR) Annual Meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research

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Published: 2021-04-28   Modified: 2025-01-30  

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