| Budget Amount *help |
¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2023: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2022: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2021: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Outline of Final Research Achievements |
It has previously shown that rehabilitation-dependent delivery of the AMPA receptor into synapses leads to functional recovery after cortical injury. However, it is unclear how the synaptic accumulation of AMPA receptors compensates for motor function. To elucidate the function of AMPA receptors accumulated in the peri-injury area, we attempted to manipulate them spatiotemporally in individual animals using an optogenetic approach (CALI method). In this study, we established a subunit-specific optical inactivation of AMPA receptor subunits such as GluA1/1 and GluA2/3 in vitro and in vivo.
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