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Creation of 3D cancer tissue model using high-strength porous gel and development of new cancer stem cell-targeted therapy

Research Project

Project/Area Number 21H03802
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 90110:Biomedical engineering-related
Research InstitutionHokkaido University

Principal Investigator

Tsuda Masumi  北海道大学, 医学研究院, 准教授 (30431307)

Co-Investigator(Kenkyū-buntansha) 野々山 貴行  北海道大学, 先端生命科学研究院, 准教授 (50709251)
田中 伸哉  北海道大学, 医学研究院, 教授 (70261287)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2023: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2022: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2021: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywordsがん幹細胞 / がん幹細胞ニッシェ / ハイドロゲル / がん治療法 / ポーラスゲル / 癌治療法
Outline of Research at the Start

がんの根絶には、がん組織におけるがん幹細胞の誕生・生存機構の解明が必須である。我々は近年、高強度ハイドロゲルを用いてがん幹細胞を迅速に誘導するリプログラミング現象を見出した(Nature Biomed. Eng. 2021)。これは、高機能ハイドロゲルが分化したがん細胞を未分化ながん幹細胞へ初期化することを可能としたものである。本研究では高強度ポーラスゲルを最適化して3次元がん組織モデルを創出し、がん組織の多種細胞間の時空間的相互作用、およびがん幹細胞が誕生・生存・形質転換する動的分子機構を解明する。最終的にはがん幹細胞を根絶し得る治療標的分子を同定し、がん制圧に向けた基盤の構築を目指す。

Outline of Final Research Achievements

Cancer stem cells are thought to be created and survive in a special microenvironment (cancer stem cell niche) in cancer tissues and cause cancer recurrence; however, the details are unknown. In this research, based on the hydrogel-based cancer stem cell reprogramming technique that we have recently developed, we created cancer stem cell niches utilizing the hydrogel in order to mimic cancer stem cell reprogramming in cancer tissues, and analyzed the creation and survival mechanisms of cancer stem cells. Glioblastoma cells promoted reprogramming through direct interaction with vascular endothelial cells. In addition, they adhered to astrocytes and proliferated dominantly, and secreted proteins derived from astrocytes increased stemness of glioblastoma cells. Furthermore, through drug screening, we identified several drugs that is effective against glioblastoma stem cells.

Academic Significance and Societal Importance of the Research Achievements

ヒト膠芽腫細胞では低栄養環境および血管内皮細胞との直接接触がリプログラミングを促進した。膠芽腫では特徴的な微小血管増生や糸球体様血管束が認められ、その周囲ではpalisading necrosis(低酸素、低栄養環境)が認められることから、癌幹細胞が生成・生存しやすい環境が整っていることが示唆された。また、アストロサイト由来の分泌蛋白が幹細胞性を増加させたことから、脳に存在する支持細胞が至適な環境下で腫瘍の幹細胞性を誘導し、がん幹細胞の生存に有利に機能していることが示唆された。膠芽腫幹細胞に対して効果が認められた薬剤は、高悪性度の膠芽腫に対して生命予後を改善できる可能性があると期待される。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (50 results)

All 2024 2023 2022 2021 2020 Other

All Int'l Joint Research (1 results) Journal Article (25 results) (of which Int'l Joint Research: 15 results,  Peer Reviewed: 25 results,  Open Access: 21 results) Presentation (23 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] University Hospital Magdeburg(ドイツ)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Structure-changeable luminescent Eu(III) complex as a human cancer grade probing system for brain tumor diagnosis2024

    • Author(s)
      M. Wang, M. Kono, Y. Yamaguchi, J. Islam, S. Shoji, Y. Kitagawa, K. Fushimi, S. Watanabe, G. Matsuba, A. Yamamoto, M. Tanaka, M. Tsuda, S. Tanaka, Y. Hasegawa
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1 Pages: 778-778

    • DOI

      10.1038/s41598-023-50138-9

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant2024

    • Author(s)
      Tamura Tomokazu、Irie Takashi、Deguchi Sayaka、Yajima Hisano、Tsuda Masumi、Nasser Hesham、Mizuma Keita、Plianchaisuk Arnon、Suzuki Saori et al.
    • Journal Title

      Nature Communications

      Volume: 15 Issue: 1 Pages: 1176-1176

    • DOI

      10.1038/s41467-024-45274-3

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Virological characteristics of the SARS-CoV-2 BA.2.86 variant2024

    • Author(s)
      Tamura Tomokazu、Mizuma Keita、Nasser Hesham、Deguchi Sayaka、Padilla-Blanco Miguel、Oda Yoshitaka、Uriu Keiya、Tolentino Jarel E.M.、Tsujino Shuhei、Suzuki Rigel、Kojima Isshu、Nao Naganori、Shimizu Ryo、Wang Lei、Tsuda Masumi、Jonathan Michael、Kosugi Yusuke、et al.
    • Journal Title

      Cell Host &Microbe

      Volume: 32 Issue: 2 Pages: 170-180.e12

    • DOI

      10.1016/j.chom.2024.01.001

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Akaluc bioluminescence offers superior sensitivity to track in vivo dynamics of SARS-CoV-2 infection.2024

    • Author(s)
      Tamura T, Ito H, Torii S, Wang L, Suzuki R, Tsujino S, Kamiyama A, Oda Y, Tsuda M, Morioka Y, Suzuki S, Shirakawa K, Sato K, Yoshimatsu K, Matsuura Y, Iwano S, Tanaka S, Fukuhara T.
    • Journal Title

      iScience

      Volume: 27

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant2023

    • Author(s)
      Ito Jumpei、Suzuki Rigel、Uriu Keiya et al.
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 2671-2671

    • DOI

      10.1038/s41467-023-38188-z

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants2023

    • Author(s)
      Tamura Tomokazu、Ito Jumpei、Uriu Keiya、Zahradnik Jiri、Kida Izumi、Anraku Yuki、Nasser Hesham、Shofa Maya、Oda Yoshitaka、Lytras Spyros、Nao Naganori、Itakura Yukari、Deguchi Sayaka、Suzuki Rigel...Suzuki Saori et al.
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 2800-2800

    • DOI

      10.1038/s41467-023-38435-3

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.52023

    • Author(s)
      Tamura T, Yamasoba D, Oda Y, Ito J, Kamasaki T, Nao N, Hashimoto R, Fujioka Y, Suzuki R, Wang L, Ito H, Kashima Y, Kimura I, Kishimoto M, Tsuda M, Sawa H, Yoshimatsu K, Yamamoto Y, Nagamoto T, Kanamune J, Suzuki Y, Ohba Y, et al.
    • Journal Title

      Communications Biology

      Volume: 6 Issue: 1 Pages: 772-772

    • DOI

      10.1038/s42003-023-05081-w

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Geometrical analysis identified morphological features of hydrogel-induced cancer stem cells in synovial sarcoma model cells2023

    • Author(s)
      Ferdous Zannatul、Clement Jean-Emmanuel、Gong Jian Ping、Tanaka Shinya、Komatsuzaki Tamiki、Tsuda Masumi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 642 Pages: 41-49

    • DOI

      10.1016/j.bbrc.2022.12.040

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats2023

    • Author(s)
      Koizumi Takuya、Watanabe Masaya、Yokota Takashi、Tsuda Masumi、Handa Haruka、Koya Jiro、Nishino Kotaro、Tatsuta Daishiro、Natsui Hiroyuki、Kadosaka Takahide、Koya Taro、Nakao Motoki、Hagiwara Hikaru、Kamada Rui、Temma Taro、Tanaka Shinya、Anzai Toshihisa
    • Journal Title

      Frontiers in Cardiovascular Medicine

      Volume: 10 Pages: 1005408-1005408

    • DOI

      10.3389/fcvm.2023.1005408

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction2023

    • Author(s)
      Tanikawa Satoshi、Ebisu Yuki、Seldacik Tomas、Semba Shingo、Nonoyama Takayuki、Kurokawa Takayuki、Hirota Akira、Takahashi Taiga、Yamaguchi Kazushi、Imajo Masamichi、Kato Hinako、Nishimura Takuya、Tanei Zen-ichi、Tsuda Masumi、Nemoto Tomomi、Gong Jian Ping、Tanaka Shinya
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 2233-2233

    • DOI

      10.1038/s41598-023-28870-z

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel rapid immunohistochemistry using an alternating current electric field identifies Rac and Cdc42 activation in human colon cancer FFPE tissues2022

    • Author(s)
      Tsuda M, Horio R, Wang L, Takenami T, Moriya J, Suzuka J, Sugino H, Tanei Z, Tanino M, Tanaka S.
    • Journal Title

      Sci Rep.

      Volume: 12 Issue: 1 Pages: 1733-1733

    • DOI

      10.1038/s41598-022-05892-7

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant2022

    • Author(s)
      Suzuki Rigel、Yamasoba Daichi、Kimura Izumi、Wang Lei他
    • Journal Title

      Nature

      Volume: 603 Issue: 7902 Pages: 700-705

    • DOI

      10.1038/s41586-022-04462-1

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike2022

    • Author(s)
      Yamasoba Daichi、Kimura Izumi、Nasser Hesham他
    • Journal Title

      Cell

      Volume: 未定 Issue: 12 Pages: 2103-2115

    • DOI

      10.1016/j.cell.2022.04.035

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of the context of downstream N- and free N-glycomic alterations induced by swainsonine in HepG2 cells2022

    • Author(s)
      Morikawa Chie、Sugiura Kanako、Kondo Keina、Yamamoto Yurie、Kojima Yuma、Ozawa Yurika、Yoshioka Hiroki、Miura Nobuaki、Piao Jinhua、Okada Kazue、Hanamatsu Hisatoshi、Tsuda Masumi、Tanaka Shinya、Furukawa Jun-ichi、Shinohara Yasuro
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - General Subjects

      Volume: 1866 Issue: 9 Pages: 130168-130168

    • DOI

      10.1016/j.bbagen.2022.130168

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.52022

    • Author(s)
      Kimura et al.
    • Journal Title

      Cell

      Volume: 185 Issue: 21 Pages: 3992-4007

    • DOI

      10.1016/j.cell.2022.09.018

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant2022

    • Author(s)
      Saito et al.
    • Journal Title

      Cell Host & Microbe

      Volume: 30 Issue: 11 Pages: 1540-1540

    • DOI

      10.1016/j.chom.2022.10.003

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Force-triggered rapid microstructure growth on hydrogel surface for on-demand functions2022

    • Author(s)
      Mu Qifeng、Cui Kunpeng、Wang Zhi Jian、Matsuda Takahiro、Cui Wei、Kato Hinako、Namiki Shotaro、Yamazaki Tomoko、Frauenlob Martin、Nonoyama Takayuki、Tsuda Masumi、Tanaka Shinya、Nakajima Tasuku、Gong Jian Ping
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 6213-6213

    • DOI

      10.1038/s41467-022-34044-8

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation2021

    • Author(s)
      Saito Akatsuki、Irie Takashi、Suzuki Rigel、Maemura Tadashi、Nasser Hesham、Uriu Keiya、Kosugi Yusuke、Other 43 authors、Tanaka Shinya、Nakagawa So、Ikeda Terumasa、Fukuhara Takasuke、Kawaoka Yoshihiro、Sato Kei、The Genotype to Phenotype Japan (G2P-Japan) Consortium
    • Journal Title

      Nature

      Volume: 602 Issue: 7896 Pages: 300-306

    • DOI

      10.1038/s41586-021-04266-9

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels2021

    • Author(s)
      Suzuka J, Tsuda M, Wang L, Kohsaka S, Kishida K, Semba S, Sugino H, Aburatani S, Frauenlob M, Kurokawa T, Kojima S, Ueno T, Ohmiya Y, Mano H, Yasuda K, Gong JP, Tanaka S
    • Journal Title

      Nat Biomed Eng

      Volume: - Issue: 8 Pages: 914-925

    • DOI

      10.1038/s41551-021-00692-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of BMP and Wnt signals leading to EMT in colon adenocarcinoma with heterotopic ossification.2021

    • Author(s)
      Katono N, Tsuda M, Suzuka J, Oda Y, Wang L, Tanei ZI, Tanino M, Ohata T, Nagabuchi E, Ishida Y, Kimura S, Iwanaga T, Tanaka S.
    • Journal Title

      Annals of Clinical and Laboratory Science

      Volume: 51 Pages: 271-276

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of H3K27 trimethylation is frequent in IDH1-R132H but not in non-canonical IDH1/2 mutated and 1p/19q codeleted oligodendroglioma: a Japanese cohort study2021

    • Author(s)
      Habiba Umma、Sugino Hirokazu、Yordanova Roumyana、Ise Koki、Tanei Zen-ichi、Ishida Yusuke、Tanikawa Satoshi、Terasaka Shunsuke、Sato Ken-ichi、Kamoshima Yuuta、Katoh Masahiko、Nagane Motoo、Shibahara Junji、Tsuda Masumi、Tanaka Shinya
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 9 Issue: 1 Pages: 95-95

    • DOI

      10.1186/s40478-021-01194-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive molecular profiling of pulmonary pleomorphic carcinoma2021

    • Author(s)
      Nagano Masaaki、Kohsaka Shinji、Hayashi Takuo、Ueno Toshihide、Kojima Shinya、Shinozaki-Ushiku Aya、Morita Shigeki、Tsuda Masumi、Tanaka Shinya、Shinohara Toshiya、Omori Yuko、Sugaya Fumiko、Kato Hiroaki、Narita Yoshiaki、Nakajima Jun、Suzuki Kenji、Takamochi Kazuya、Mano Hiroyuki
    • Journal Title

      npj Precision Oncology

      Volume: 5 Issue: 1 Pages: 57-57

    • DOI

      10.1038/s41698-021-00201-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aberrant expression of MYD88 via RNA‐controlling CNOT4 and EXOSC3 in colonic mucosa impacts generation of colonic cancer2021

    • Author(s)
      Tsuda Masumi、Noguchi Misa、Kurai Tsuyoshi、Ichihashi Yuji、Ise Koki、Wang Lei、Ishida Yusuke、Tanino Mishie、Hirano Satoshi、Asaka Masahiro、Tanaka Shinya
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 12 Pages: 5100-5113

    • DOI

      10.1111/cas.15157

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hydroxyapatite‐hybridized double‐network hydrogel surface enhances differentiation of bone marrow‐derived mesenchymal stem cells to osteogenic cells2021

    • Author(s)
      Kaibara Takuma、Wang Lei、Tsuda Masumi、Nonoyama Takayuki、Kurokawa Takayuki、Iwasaki Norimasa、Gong Jian Ping、Tanaka Shinya、Yasuda Kazunori
    • Journal Title

      Journal of Biomedical Materials Research Part A

      Volume: 110 Issue: 4 Pages: 747-760

    • DOI

      10.1002/jbm.a.37324

    • Related Report
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    • Peer Reviewed
  • [Journal Article] Synthetic poly(2‐acrylamido‐2‐methylpropanesulfonic acid) gel induces chondrogenic differentiation of ATDC5 cells via a novel protein reservoir function2020

    • Author(s)
      Semba Shingo、Kitamura Nobuto、Tsuda Masumi、Goto Keiko、Kurono Sadamu、Ohmiya Yoshihiro、Kurokawa Takayuki、Gong Jian Ping、Yasuda Kazunori、Tanaka Shinya
    • Journal Title

      Journal of Biomedical Materials Research Part A

      Volume: 109 Issue: 3 Pages: 354-364

    • DOI

      10.1002/jbm.a.37028

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ハイドロゲルが解き明かすがん幹細胞の特性と治療戦略2024

    • Author(s)
      津田真寿美
    • Organizer
      第113回日本病理学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ハイドロゲルを用いた新規治療耐性細胞株の樹立2024

    • Author(s)
      王磊、窪田武哲、津田真寿美、小田義崇、平野聡、グン剣萍、田中伸哉
    • Organizer
      第113回日本病理学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Analysis of stiffness of tumor microenvironment on cancer stemness generation using hydrogels2024

    • Author(s)
      Yanpeng Sun, Yuheng Nie, Masumi Tsuda, Lei Wang, Jian Ping Gong, Shinya Tanaka
    • Organizer
      第113回日本病理学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Investigation of electric charge on cancer stem cell generation in tumor microenvironment2024

    • Author(s)
      Yuheng Nie, Yanpeng Sun, Masumi Tsuda, Lei Wang, Jian Ping Gong, Shinya Tanaka
    • Organizer
      第113回日本病理学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] TKIs耐性膠芽腫細胞の特性と耐性メカニズムの解析2023

    • Author(s)
      津田真寿美、王磊、小田義崇、谷川聖、種井善一、田中伸哉
    • Organizer
      第112回日本病理学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ハイドロゲルを用いた中皮腫幹細胞の創出および治療標的分子の探索2023

    • Author(s)
      加藤万里絵、杉野弘和、津田真寿美、王 磊、種井善一、小田義崇、谷川聖、グン剣萍、田中伸哉
    • Organizer
      第112回日本病理学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ハイドロゲルを用いた骨肉腫細胞における幹細胞特性の迅速誘導と新規治療標的分子の探索2023

    • Author(s)
      甲斐原拓真、王磊、津田真寿美、野々山貴行、黒川孝幸、グン剣萍、岩崎倫政、田中伸哉、安田和則
    • Organizer
      第142回北海道整形災害外科学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ハイドロゲルによる幹細胞性誘導を用いて同定したCXCR4の髄膜腫における病理学的、生物学的役割の探索2023

    • Author(s)
      小田義崇、津田真寿美、王磊、田中伸哉
    • Organizer
      第27回日本がん分子標的治療学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ある種の合成高分子ハイドロゲルは浸潤能の高い滑膜肉腫幹細胞を誘導する2023

    • Author(s)
      寺島祐樹、津田真寿美、小田義崇、谷川聖、種井善一、王磊、グン剣萍、田中伸哉
    • Organizer
      第40回分子病理学研究会 クラークシンポジウム
    • Related Report
      2023 Annual Research Report
  • [Presentation] ハイドロゲルを用いた中皮腫幹細胞の創出およびその発現遺伝子の検討2023

    • Author(s)
      加藤万里絵、杉野弘和、津田真寿美、王磊、種井 善一、小田義崇、谷川聖、グン剣萍、田中伸哉
    • Organizer
      第40回分子病理学研究会 クラークシンポジウム
    • Related Report
      2023 Annual Research Report
  • [Presentation] Advancing the Detection of Cancer Stem Cells Using Line Illumination Raman Microscopy and Hydrogel Substrates2023

    • Author(s)
      Jean-Emmanuel Clement, Zannatul Ferdous, Masumi Tsuda, Shinya Tanaka, Jian Ping Gong, Thomas Bocklitz, Katsumasa Fujita, Tamiki Komatsuzaki
    • Organizer
      The 11th International Conference on Biological Physics
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Advancing cancer stem cell detection through line illumination Raman microscope and hydrogel substrate2023

    • Author(s)
      Jean-Emmanuel Clement, Zannatul Ferdous, Masumi Tsuda, Shinya Tanaka, Jian Ping Gong, JN Taylor, Thomas Bocklitz, Katsumasa Fujita, Tamiki Komatsuzaki
    • Organizer
      The Great SCIentific exchange
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hydrogel PCDME creates pancreatic cancer stem cells in OXPHOS metabolic state with TXNIP elevation2023

    • Author(s)
      Lei Wang, Yuma Aoki, Masumi Tsuda, Yusuke Saito, Takenori Kubota, Yoshitaka Oda, Satoshi Hirano, Jian Ping Gong, Shinya Tanaka
    • Organizer
      The 82nd Annual Meeting of Japanese Cancer Association
    • Related Report
      2023 Annual Research Report
  • [Presentation] Investigation of cancer stem cell generation by simulating hydrogel- based tumor microenvironment2023

    • Author(s)
      Yuheng Nie, Yanpeng Sun, Masumi Tsuda, Lei Wang, Jian ping Gong, Shinya Tanaka
    • Organizer
      The 82nd Annual Meeting of Japanese Cancer Association
    • Related Report
      2023 Annual Research Report
  • [Presentation] Analysis of the effect of stiffness of cancer microenvironment on stemness induction of cancer cells using hydrogels.2023

    • Author(s)
      Yanpeng Sun, Yuheng Nie, Masumi Tsuda, Lei Wang, Jian ping Gong, Shinya Tanaka
    • Organizer
      The 82nd Annual Meeting of Japanese Cancer Association
    • Related Report
      2023 Annual Research Report
  • [Presentation] Analysis of cancer stem cells at invasive front niche2022

    • Author(s)
      Masumi Tsuda, Shinya Tanaka
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] RNA制御分子CNOT4およびEXOSC3を介したMYD88の発現亢進は大腸癌の発生母地となる2022

    • Author(s)
      津田真寿美、倉井毅、市橋裕司、伊勢昂生、王磊、石田雄介、谷野美智枝、平野聡、浅香正博、田中伸哉
    • Organizer
      第111回日本病理学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 肺癌における新規作用機序チロシンキナーゼ阻害剤の解析2022

    • Author(s)
      津田真寿美、王磊、田中伸哉
    • Organizer
      第26回日本がん分子標的治療学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Identification of novel LCSCs marker CMKLR1 via reprogramming by Double-Network hydrogel2022

    • Author(s)
      Masumi Tsuda, Michio Tani, Jun Suzuka, Lei Wang, Akinobu Taketomi, Shinya Tanaka
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Research development and medical application of cancer stem cells using high-functioning hydrogel2022

    • Author(s)
      Masumi Tsuda
    • Organizer
      Understanding of novel biological phenomena in cancer and immunology research
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of cancer stem cells with invasive capacity by Hydrogel-Activated Reprogramming (HARP) phenomenon using PNaSS hydrogel2022

    • Author(s)
      Masumi Tsuda, Jun Suzuka, Yoshitaka Oda, Lei Wang, Yusuke Saito, Jian Ping Gong, Shinya Tanaka
    • Organizer
      12th AACR-JCA Joint Conference: Breakthroughs in Cancer Research: Translating Knowledge into Practice
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高分子ハイドロゲルによるリプログラミングを利用した癌幹細胞標的治療薬の同定2021

    • Author(s)
      津田真寿美、鈴鹿淳、王磊、田中伸哉
    • Organizer
      第25回日本がん分子標的治療学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 大腸正常粘膜においてRNA制御分子CNOT4およびEXOSC3を介したMYD88の発現亢進は大腸癌の発生に関与する2021

    • Author(s)
      津田真寿美, 王磊, 平野聡, 浅香正博, 田中伸哉
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞培養器、細胞培養キット、および細胞培養方法2021

    • Inventor(s)
      黒川孝幸、勝山吉徳、グン剣萍、田中伸哉、津田真寿美
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-151208
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report

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Published: 2021-04-28   Modified: 2025-01-30  

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