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Development of a handy system for rapid drug monitoring from tiny amounts of blood

Research Project

Project/Area Number 21H03805
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 90110:Biomedical engineering-related
Research InstitutionKeio University

Principal Investigator

Ogata Genki  慶應義塾大学, 理工学部(矢上), 特任准教授 (80452829)

Co-Investigator(Kenkyū-buntansha) 日比野 浩  大阪大学, 大学院医学系研究科, 教授 (70314317)
栄長 泰明  慶應義塾大学, 理工学部(矢上), 教授 (00322066)
楠原 洋之  東京大学, 大学院薬学系研究科(薬学部), 教授 (00302612)
椎木 弘  大阪公立大学, 大学院工学研究科, 教授 (70335769)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2023: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2022: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2021: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords導電性ダイヤモンド電極 / 薬物動態 / 分子インプリント / TDM / 治療薬物モニタリング / ダイヤモンド電極 / 分子インプリンティング / 抗がん剤 / ボロンドープダイヤモンド電極 / 電気化学センサ / 分子鋳型 / ドキソルビシン / パゾパニブ / 分子標的薬 / ダイヤモンドセンサ / 導電性ダイヤモンド / 電気化学
Outline of Research at the Start

治療薬物モニタリング(Therapeutic Drug Monitoring: TDM)は、薬物の治療効果や患者QOLの飛躍的な向上が見込まれるため、近年、その活用が医療現場から大きく期待されている。しかしながら、薬の血中濃度を臨床の現場で簡便かつスピーディに測る技術が確立していないために、TDMが積極的に実施されている医療機関は非常に少ない。そこで、本研究では、血中の薬物濃度を、“極微量”の血液から“その場で瞬時に”定量する「ハンディ型の迅速薬物モニタリングシステム」の構築を目的とする。新規ポータプルシステムは、TDMを介したオーダーメイド治療を加速し、安心安全な医療の提供に貢献する。

Outline of Final Research Achievements

Simple monitoring of drug concentrations in blood is required to improve the efficacy and safety of drug treatment. Electrochemical methods enable rapid measurement, but quantification has been problematic when substances react at the same potential. Therefore, we developed an MIP-BDD electrode with a molecularly implanted polymer (MIP) modified on boron-doped diamond (BDD) for selective drug detection: the MIP traps specific molecules and can selectively detect target molecules in a mixture. In this study, the anticancer drug doxorubicin (DOX) was used as a template molecule, and only DOX showed a reduction reaction at the MIP-BDD electrode. DOX can also be measured in plasma and is expected to be applied to drug blood concentration monitoring.

Academic Significance and Societal Importance of the Research Achievements

本研究で開発した血漿中薬物測定システムは、ダイヤモンド電極にMIPを修飾したセンサーにより、従来の大型分析装置が不要で、迅速・簡便・安価に薬物を測定できる。この成果により、効果を最大化し副作用を最小限にする投薬方法の開発、過剰投与の抑制と医療費削減、臨床医学や薬物動態学の新たな分析ツールの提供が期待される。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (36 results)

All 2024 2023 2022 2021

All Journal Article (12 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 2 results) Presentation (21 results) (of which Int'l Joint Research: 6 results,  Invited: 1 results) Book (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Real-Time Measurement of Antiglaucoma Drugs in Porcine Eyes Using Boron-Doped Diamond Microelectrodes2024

    • Author(s)
      Ogata Genki、Yoneda Mao、Ogawa Risa、Hanawa Ai、Asai Kai、Yamagishi Reiko、Honjo Megumi、Aihara Makoto、Einaga Yasuaki
    • Journal Title

      ACS Sensors

      Volume: 9 Issue: 2 Pages: 781-788

    • DOI

      10.1021/acssensors.3c02088

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Designing Molecularly Imprinted Polymer-Modified Boron-Doped Diamond Electrodes for Highly Selective Electrochemical Drug Sensors2024

    • Author(s)
      Ishii Kanako、Ogata Genki、Yamamoto Takashi、Sun Shuyi、Shiigi Hiroshi、Einaga Yasuaki
    • Journal Title

      ACS Sensors

      Volume: 9 Issue: 3 Pages: 1611-1619

    • DOI

      10.1021/acssensors.4c00360

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measuring the Permittivity of Liposome and Yeast Using a 3D-printed Electrode-replaceable Measuring Cell2024

    • Author(s)
      KAGEYAMA Yuji、SUEOKA Haruna、KIMURA Akira、SATO Masaki、ITO Akira、HORIE Tetsuro、OGATA Genki、EINAGA Yasuaki、SUZUKI Hiroaki、MURAKAMI Shingo
    • Journal Title

      Advanced Biomedical Engineering

      Volume: 13 Issue: 0 Pages: 90-99

    • DOI

      10.14326/abe.13.90

    • ISSN
      2187-5219
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrochemical Diagnosis of Urinary Tract Infection Using Boron-Doped Diamond Electrodes2023

    • Author(s)
      Zhang Ziping、Ogata Genki、Asai Kai、Yamamoto Takashi、Einaga Yasuaki
    • Journal Title

      ACS Sensors

      Volume: 8 Issue: 11 Pages: 4245-4252

    • DOI

      10.1021/acssensors.3c01569

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urine protein quantification in human urine on boron-doped diamond electrodes based on the electrochemical reaction of Coomassie brilliant blue2023

    • Author(s)
      Aoki Hiroshi、Miyazaki Risa、Ohama Miho、Murata Michio、Asai Kai、Ogata Genki、Einaga Yasuaki
    • Journal Title

      The Analyst

      Volume: 148 Issue: 18 Pages: 4396-4405

    • DOI

      10.1039/d3an01000g

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A strategy for low-cost portable monitoring of plasma drug concentrations using a sustainable boron-doped-diamond chip2023

    • Author(s)
      Takuro Saiki et al.
    • Journal Title

      Heliyon

      Volume: 9 Issue: 5 Pages: e15963-e15963

    • DOI

      10.1016/j.heliyon.2023.e15963

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dissolved ozone sensing in water and blood based on commercial screen-printed and BDD electrodes2023

    • Author(s)
      Petani Lisa、Llupa Lea、Peng Zhen、Ogata Genki、Koker Liane、Gengenbach Ulrich、Einaga Yasuaki、Pylatiuk Christian
    • Journal Title

      2023 IEEE Biomedical Circuits and Systems Conference (BioCAS)

      Volume: 1 Pages: 1-5

    • DOI

      10.1109/biocas58349.2023.10388985

    • Related Report
      2023 Annual Research Report
  • [Journal Article] A rapid and simple electrochemical detection of the free drug concentration in human serum using boron-doped diamond electrodes2022

    • Author(s)
      Moriyama Hideto、Ogata Genki、Nashimoto Haruma、Sawamura Seishiro、Furukawa Yoshiaki、Hibino Hiroshi、Kusuhara Hiroyuki、Einaga Yasuaki
    • Journal Title

      The Analyst

      Volume: 147 Issue: 20 Pages: 4442-4449

    • DOI

      10.1039/d2an01037b

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrochemical detection of triamterene in human urine using boron-doped diamond electrodes2022

    • Author(s)
      Ishii Kanako、Ogata Genki、Einaga Yasuaki
    • Journal Title

      Biosensors and Bioelectronics

      Volume: 217 Pages: 114666-114666

    • DOI

      10.1016/j.bios.2022.114666

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of boron doped diamond electrodes to electrochemical gas sensor2022

    • Author(s)
      Triana Yunita、Ogata Genki、Einaga Yasuaki
    • Journal Title

      Current Opinion in Electrochemistry

      Volume: 36 Pages: 101113-101113

    • DOI

      10.1016/j.coelec.2022.101113

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood Oxygen Sensor Using a Boron-Doped Diamond Electrode2022

    • Author(s)
      Triana Yunita、Ogata Genki、Tomisaki Mai、Irkham、Einaga Yasuaki
    • Journal Title

      Analytical Chemistry

      Volume: 94 Issue: 9 Pages: 3948-3955

    • DOI

      10.1021/acs.analchem.1c04999

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of Pharmacokinetics in the Cochlea of the Inner Ear2021

    • Author(s)
      Sawamura Seishiro、Ogata Genki、Asai Kai、Razvina Olga、Ota Takeru、Zhang Qi、Madhurantakam Sasya、Akiyama Koei、Ino Daisuke、Kanzaki Sho、Saiki Takuro、Matsumoto Yoshifumi、Moriyama Masato、Saijo Yasuo、Horii Arata、Einaga Yasuaki、Hibino Hiroshi
    • Journal Title

      Frontiers in Pharmacology

      Volume: 12 Pages: 1-11

    • DOI

      10.3389/fphar.2021.633505

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ダイヤモンド電極を用いた緑内障点眼薬ブリモニジンの電気化学測定2024

    • Author(s)
      小川 梨紗、緒方 元気、山岸 麗子、本庄 惠、相原 一、栄長 泰明
    • Organizer
      電気化学会第91回大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ダイヤモンド微小電極を用いた緑内障点眼薬のリアルタイム測定2024

    • Author(s)
      緒方 元気、米田 真央、小川 梨紗、花輪 藍、浅井 開、山岸 麗子、本庄 恵、相原 一、栄長 泰明
    • Organizer
      第 101 回日本生理学会大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Electrochemical Detection of NaNO2 in Human Urine Using Boron-Doped Diamond Electrode.2023

    • Author(s)
      Ziping ZHANG, Genki OGATA, Kai ASAI, Takashi YAMAMOTO, Yasuaki EINAGA
    • Organizer
      The Nineteenth International Symposium on Electroanalytical Chemistry (19th ISEAC)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrochemical Detection of NaNO2 in Human Urine Using Boron-Doped Diamond Electrode2023

    • Author(s)
      張 子平、緒方 元気、浅井 開、山本 崇史、栄長 泰明
    • Organizer
      2023電気化学秋季大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Selective Electrochemical Detection of Doxorubicin Using Molecularly Imprinted Polymer-Modified Boron Doped Diamond Electrodes2023

    • Author(s)
      Kanako Ishii, Genki Ogata, Takashi Yamamoto, Shuyi Sun, Hiroshi Shiigi, Yasuaki Einaga
    • Organizer
      The nanoBalkan International Conference (NB2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Selective Rapid Plasma Molecular-Targeted Drug Monitoring with Boron-Doped Diamond Electrode2023

    • Author(s)
      Genki Ogata, Takuro Saiki, Yasuo Saijo, Yasuaki Einaga, and Hiroshi Hibino
    • Organizer
      The nanoBalkan International Conference (NB2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo real time measurements by BOO microelectrode2023

    • Author(s)
      Genki Ogata
    • Organizer
      The nanoBalkan International Conference (NB2023), 4th Workshop NANOTECHNOLOGIES FOR 21st CENTURY COOPERATION EVENT BETWEEN ALBANIA, JAPAN AND SPAIN
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rapid Measurement of Plasma molecular-targeted Drug Concentration with boron-doped diamond electrode2023

    • Author(s)
      Genki Ogata, Takuro Saiki, Yasuo Saijo, Yasuaki Einaga, and Hiroshi Hibino
    • Organizer
      2023 MRS Fall Meeting & Exhibit
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ダイヤモンドマイクロ電極を用いた緑内障点眼薬の豚眼内リアルタイム測定2023

    • Author(s)
      緒方 元気、米田 真央、小川 梨紗、花輪 藍、浅井 開、山岸 麗子、本庄 恵、相原 一、栄長 泰明
    • Organizer
      第97回日本薬理学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 分子鋳型ポリマー修飾ダイヤモンド電極によるドキソルビシンの高選択的検出2023

    • Author(s)
      石井夏奈子, 緒方元気, 山本崇史, 孫術益, 椎木弘, 栄長泰明
    • Organizer
      電気化学会第90回大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ダイヤモンド電極を用いたヒト尿中の利尿薬トリアムテレンの検出2022

    • Author(s)
      石井夏奈子、緒方元気、栄長泰明
    • Organizer
      2022年電気化学会第89回大会 (第70回化学センサ研究発表会)
    • Related Report
      2022 Annual Research Report
  • [Presentation] ヒト尿中の利尿薬トリアムテレンのダイヤモンド電極を用いた電気化学的検出2022

    • Author(s)
      石井夏奈子、緒方元気、栄長泰明
    • Organizer
      第61回日本生体医工学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ナフィオン修飾ダイヤモンド電極によるドーパミンの選択的電気化学測定2022

    • Author(s)
      奈佐和樹、イルハム、緒方元気、栄長泰明
    • Organizer
      2022年電気化学秋季大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ダイヤモンド電極を用いた緑内障点眼薬ブリモニジンの電気化学測定2022

    • Author(s)
      小川 梨紗、 緒方 元気、山岸 麗子、本庄 惠、相原 一、栄長 泰明
    • Organizer
      2022年度生理研研究会 「細胞の局所コミュニティ研究会」
    • Related Report
      2022 Annual Research Report
  • [Presentation] Rapid Measurement of Drug Concentration of Pazopanib in Human Plasma with Diamond Sensor2022

    • Author(s)
      齋木 琢郎,緒方 元気,澤村 晴志朗,ラズビナ オリガ,渡邊 航太,加藤 里都,浅井 開,松本 吉史,森山 雅人,楠原 洋之,栄長 泰明,西條 康夫,日比野 浩
    • Organizer
      第19回日本臨床腫瘍学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] A Method Designed for Point-of-Care System Monitoring Plasma Concentration of an Anticancer Molecular Targeting Drug with Diamond Electrode2022

    • Author(s)
      齋木 琢郎,緒方 元気,澤村 晴志朗,ラズビナ オリガ,渡邊 航太,加藤 里都,浅井 開,松本 吉史,森山 雅人,楠原 洋之,栄長 泰明,西條 康夫,日比野 浩
    • Organizer
      第 95 回日本薬理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ダイヤモンドセンサを用いた血漿中分子標的薬パゾパニブ迅速濃度測定機の開発2021

    • Author(s)
      緒方 元気、齋木 琢郎、澤村 晴志朗、ラズビナ オリガ、渡邉 航太、加藤 理都、浅井 開、花輪 藍、松本 吉史、森山 雅人、西條 康夫、栄長 泰明、日比野 浩
    • Organizer
      第139回 日本薬理学会近畿部会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 血漿パゾパニブ濃度の迅速・簡便測定を目指した計測システムの構築2021

    • Author(s)
      緒方 元気、齋木 琢郎、澤村 晴志朗、ラズビナ オリガ、渡邉 航太、加藤理都、浅井 開、花輪 藍、松本 吉史、森山 雅人、西條 康夫、楠原 洋之、栄長 泰明、日比野 浩
    • Organizer
      第60回日本生体医工学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ダイヤモンド電極を用いた分子標的薬パゾパニブ血漿中濃度の測定2021

    • Author(s)
      緒方元気、齋木琢郎、澤村晴志朗、ラズビナ オリガ、渡邊航太、加藤理都、浅井開、松本吉史、森山雅人、西條康夫、栄長泰明、日比野浩
    • Organizer
      2021電気化学秋季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ダイヤモンド電極を用いた抗がん剤ドキソルビシンのヒト血清中遊離型測定2021

    • Author(s)
      森山 英人、緒方 元気、梨本 遥馬、古川 良明、日比野 浩、楠原 洋之、栄長 泰明
    • Organizer
      2021電気化学秋季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Electrochemical detection of free drug fraction in human serum using boron-doped diamond electrodes.2021

    • Author(s)
      Hideto Moriyama, Haruma Nashimoto, Genki Ogata, Yoshiaki Furukawa, Hiroshi Hibino, Hiroyuki Kusuhara, Yasuaki Einaga.
    • Organizer
      The International Chemical Congress of Pacific Basin Societies 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Book] Diamond electrodes : fundamentals and applications Part 12. In vivo real time measurement of drugs.2022

    • Author(s)
      Genki Ogata, Seishiro Sawamura, Kai Asai, Hiroyuki Kusuhara, Yasuaki Einaga, Hiroshi Hibino
    • Total Pages
      10
    • Publisher
      Springer
    • ISBN
      9789811678332
    • Related Report
      2022 Annual Research Report
  • [Patent(Industrial Property Rights)] 亜硝酸塩の測定方法および亜硝酸塩の測定装置2023

    • Inventor(s)
      張子平、緒方元気、村田道生、栄長泰明、浅井開
    • Industrial Property Rights Holder
      張子平、緒方元気、村田道生、栄長泰明、浅井開
    • Industrial Property Rights Type
      特許
    • Filing Date
      2023
    • Related Report
      2023 Annual Research Report
  • [Patent(Industrial Property Rights)] ダイヤモンド電極を用いた尿中薬物電気化学センサおよび検出対象の分析法2022

    • Inventor(s)
      栄長泰明、石井夏菜子、緒方元気
    • Industrial Property Rights Holder
      栄長泰明、石井夏菜子、緒方元気
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-032039
    • Filing Date
      2022
    • Related Report
      2021 Annual Research Report

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Published: 2021-04-28   Modified: 2025-01-30  

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