| Budget Amount *help |
¥41,990,000 (Direct Cost: ¥32,300,000、Indirect Cost: ¥9,690,000)
Fiscal Year 2023: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2022: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2021: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
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| Outline of Final Research Achievements |
As a core technology that enables optical manipulation of biological processes occurring in deep tissues, we have developed a new photoswitch protein that can control the function of proteins by red light illuminaiton, which is highly permeable to biological tissues. Furthermore, by combining the photoswitch protein with DNA recombinase, we have developed a new technology that can control DNA recombination reactions with red light, and have demonstrated that this technology can control DNA recombination reactions in organs located deep within the mouse in vivo by non-invasive light illumination from outside the living body. This technology can control DNA recombination reactions in organs located deep inside the mouse (in vivo) by non-invasive light llumination from outside the body. This new photoswitch protein is expected to greatly expand the applicability of light manipulation of life phenomena.
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