| Budget Amount *help |
¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000)
Fiscal Year 2023: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2022: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2021: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
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| Outline of Final Research Achievements |
In this study, we developed functional fluorescent probes to directly measure physiological functions of living cells. The aim of this project is to reveal biological phenomena that can be functionally analyzed for the first time with this technology by combining organic chemistry and cell biology. During this project, we have developed in vivo imaging probes that reveal osteocyte/osteoclast functions using two-photon excitation microscopy. Also, we have developed novel fluorescent protein labeling probes for visualizing genome and organelle dynamics. Our results have enabled applications to the analysis of cellular functions in living animals or protein dynamics in living cells.
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