The in vivo roles of polyunsaturated fatty acid species

• Project/Area Number: 21H04798
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 48:Biomedical structure and function and related fields
• Research Institution: Juntendo University
• Principal Investigator: 横溝 岳彦 順天堂大学, 大学院医学研究科, 教授 (60302840)
• Project Period (FY): 2021-04-05 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥43,160,000 (Direct Cost: ¥33,200,000、Indirect Cost: ¥9,960,000); Fiscal Year 2023: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000); Fiscal Year 2022: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000); Fiscal Year 2021: ¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
• Keywords: 高度不飽和脂肪酸 / デサチュラーゼ / ω3脂肪酸 / ω6脂肪酸 / ステロイドホルモン / 双極症 / アラキドン酸 / ドコサヘキサエン酸 / エイコサペンタエン酸 / 双極性障害 / 不飽和脂肪酸

Outline of Research at the Start

分子内に複数の二重結合を有する高度不飽和脂肪酸(PUFA)は動脈硬化の予防や血液の流動性を高める作用が知られ、EPAやDHAがサプリメントとして広く使用されている。しかしながら、多数の分子種が存在するPUFAのそれぞれの分子種の役割は良くわかっていない。本研究では、申請者が確立したPUFA欠乏マウスで観察される貧血、脂肪肝、不妊などの異常が、どのPUFA分子種の投与によって改善するかを観察することで、それぞれのPUFA分子種の生体内での役割をあきらかにする。

Outline of Annual Research Achievements

高度不飽和脂肪酸(PUFA)は、α-リノレン酸やリノール酸などの必須脂肪酸から生合成される、生命現象に必須の分子群であるが、個々のPUFA分子種の詳細な機能や役割は明らかになっていない。本研究では独自に作製したPUFA欠乏マウスで観察される異常(男性不妊、貧血、脂肪肝)に着目し、どのPUFA分子の欠乏がこれらの異常を引き起こしているのかを明らかにし、特定のPUFA分子によるレスキューを試みた。PUFA欠乏ライディッヒ細胞株、PUFA欠乏マウス由来初代培養ライディッヒ細胞で低下していたステロイドホルモン産生は、アラキドン産やドコサペンタエン酸などのω6系列のPUFA投与によってレスキューされた。FADS2欠損マウスにPUFA除去食を与えると脂肪肝の表現型が観察された。肝臓のリピドミクス解析では、通常では観察されない非メチレン中断型のPUFAの蓄積が観察された。別の不飽和化酵素FADS1がリノール酸やリノレン酸を直接不飽和化することでこうした異常なPUFA産生が生じていると考え、FADS1/2ダブル欠損マウスで同様の実験を行ったところ、非メチレン中断型のPUFAが消失すると共に、脂肪肝の病態の悪化が観察された。以上より、非メチレン中断型のPUFAもまた、正常なPUFAと同様に脂肪肝を抑制する作用を有していることが明らかとなった。FADS1/2ダブルヘテロ欠損マウスで観察された双極症様の表現型がω3系列のDHAでレスキューされたことから、DHAは脳に取り込まれて双極症の発症を抑制していることが推定された。現在、DHAを取り込む脳の部位を特定する目的で、イメージング質量顕微鏡を用いて双極症を抑制するDHA含有脂質の局在をあきらかにする実験を行っている。

Research Progress Status

令和5年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和5年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Sanford Burnham Institute/Harvard University(米国)
• [Int'l Joint Research] Heptares Therapeutics Ltd(英国)
• [Int'l Joint Research] Max Planck Institute(ドイツ)
• [Int'l Joint Research] Fuda University(中国)
• [Int'l Joint Research] ハーバード大学(米国)
• [Int'l Joint Research] Friedrich-Schiller-University Jena(ドイツ)
• [Int'l Joint Research] Sosei-Heptares(英国)
• [Journal Article] The impact of cyclooxygenase inhibitor use on urinary prostaglandin metabolites in preterm infants (2024)
  • Author(s): Ohkawa Natsuki、Shoji Hiromichi、Ikeda Naho、Murano Yayoi、Okuno Toshiaki、Kantake Masato、Yokomizo Takehiko、Shimizu Toshiaki
  • Journal Title: Pediatrics and Neonatology Volume: 65 Issue: 2 Pages: 123-126
  • DOI: 10.1016/j.pedneo.2023.08.002
  • Peer Reviewed / Open Access
• [Journal Article] Robust and Objective Evaluation of Superficial Punctate Keratopathy in a Murine Dry Eye Model. (2024)
  • Author(s): Fujii Hiroki、Saeki Kazuko、Hoshi Sujin、Kadoya Yuri、Oshika Tetsuro、Yokomizo Takehiko
  • Journal Title: Ophthalmology Science Volume: 4 Issue: 2 Pages: 00414-00414
  • DOI: 10.1016/j.xops.2023.100414
  • Peer Reviewed / Open Access
• [Journal Article] Development of sexual dimorphism of skeletal muscles through the adrenal cortex, caused by androgen-induced global gene suppression (2024)
  • Author(s): Takahashi Fumiya、Baba Takashi、Christianto Antonius、Yanai Shogo、Lee-Okada Hyeon-Cheol、Ishiwata Keisuke、Nakabayashi Kazuhiko、Hata Kenichiro、Ishii Tomohiro、Hasegawa Tomonobu、Yokomizo Takehiko、Choi Man Ho、Morohashi Ken-ichirou
  • Journal Title: Cell Reports Volume: 43 Issue: 2 Pages: 113715-113715
  • DOI: 10.1016/j.celrep.2024.113715
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Bicarbonate signalling via G protein-coupled receptor regulates ischaemia-reperfusion injury (2024)
  • Author(s): Jo-Watanabe A, Inaba T, Osada T, Hashimoto R, Nishizawa T, Okuno T, Ihara S, Touhara K, Hattori N, Oh-Hora M, Nureki O, Yokomizo T
  • Journal Title: Nature Communications Volume: 15 Issue: 1 Pages: 1530-1530
  • DOI: 10.1038/s41467-024-45579-3
  • Peer Reviewed / Open Access
• [Journal Article] GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice (2023)
  • Author(s): Yamamoto Hirona、Lee-Okada Hyeon-Cheol、Ikeda Masashi、Nakamura Takumi、Saito Takeo、Takata Atsushi、Yokomizo Takehiko、Iwata Nakao、Kato Tadafumi、Kasahara Takaoki
  • Journal Title: Molecular Psychiatry Volume: 28 Issue: 7 Pages: 2848-2856
  • DOI: 10.1038/s41380-023-01988-2
  • Peer Reviewed / Open Access
• [Journal Article] Deficiency of leukotriene B4 receptor type 1 ameliorates ovalbumin‐induced allergic enteritis in mice. (2023)
  • Author(s): Kato Shinichi、Onishi Suzuka、Sasai Misaki、Yasuda Hiroyuki、Saeki Kazuko、Matsumoto Kenjiro、Yokomizo Takehiko
  • Journal Title: Clinical and Experimental Pharmacology and Physiology Volume: 50 Issue: 9 Pages: 766-775
  • DOI: 10.1111/1440-1681.13808
  • Peer Reviewed
• [Journal Article] FTY720 requires vitamin B12-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis (2023)
  • Author(s): Jonnalagadda Deepa、Kihara Yasuyuki、Groves Aran、Ray Manisha、Saha Arjun、Ellington Clayton、Lee-Okada Hyeon-Cheol、Furihata Tomomi、Yokomizo Takehiko、Quadros Edward V.、Rivera Richard、Chun Jerold
  • Journal Title: Cell Reports Volume: 42 Issue: 12 Pages: 113545-113545
  • DOI: 10.1016/j.celrep.2023.113545
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CYP4F22 p.V215D is a novel variant causative for lamellar ichthyosis. (2023)
  • Author(s): Ishida Yoshihiro、Saeki Kazuko、Ueda Marina、Lee‐Okada Hyeon‐Cheol、Doi Hiromi、Kambe Naotomo、Nakajima Saeko、Yokomizo Takehiko、Kabashima Kenji
  • Journal Title: Journal of the European Academy of Dermatology and Venereology Volume: - Issue: 6
  • DOI: 10.1111/jdv.19680
  • Peer Reviewed
• [Journal Article] The leukotriene B4 /BLT1-dependent neutrophil accumulation exacerbates immune complex-mediated glomerulonephritis. (2023)
  • Author(s): Shioda R, Jo-Watanabe A, Okuno T, Saeki K, Nakayama M, Suzuki Y, Yokomizo T
  • Journal Title: FASEB J Volume: 37 Issue: 2
  • DOI: 10.1096/fj.202201936r
  • Peer Reviewed / Open Access
• [Journal Article] The leukotriene B4 receptors BLT1 and BLT2 as potential therapeutic targets (2023)
  • Author(s): Yokomizo Takehiko、Shimizu Takao
  • Journal Title: Immunological Reviews Volume: 印刷中 Issue: 1 Pages: 30-41
  • DOI: 10.1111/imr.13196
  • Peer Reviewed
• [Journal Article] Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production (2022)
  • Author(s): Ri Keiken、Lee-Okada Hyeon-Cheol、Yokomizo Takehiko
  • Journal Title: Communications Biology Volume: 5 Issue: 1 Pages: 1001-1001
  • DOI: 10.1038/s42003-022-03972-y
  • Peer Reviewed / Open Access
• [Journal Article] Role of leukotriene B4 (LTB4)-LTB4 receptor 1 signaling in post-incisional nociceptive sensitization and local inflammation in mice (2022)
  • Author(s): Asahara Miho、Ito Nobuko、Hoshino Yoko、Sasaki Takaharu、Yokomizo Takehiko、Nakamura Motonao、Shimizu Takao、Yamada Yoshitsugu
  • Journal Title: PLOS ONE Volume: 17 Issue: 10 Pages: 02761350276135-02761350276135
  • DOI: 10.1371/journal.pone.0276135
  • Peer Reviewed / Open Access
• [Journal Article] Lysophosphatidic acid receptor _1/3 antagonist inhibits the activation of satellite glial cells and reduces acute nociceptive responses (2022)
  • Author(s): Hoshino Yoko、Okuno Toshiaki、Saigusa Daisuke、Kano Kuniyuki、Yamamoto Shota、Shindou Hideo、Aoki Junken、Uchida Kanji、Yokomizo Takehiko、Ito Nobuko
  • Journal Title: The FASEB Journal Volume: 36 Issue: 4
  • DOI: 10.1096/fj.202101678r
  • Peer Reviewed / Open Access
• [Journal Article] A Western Diet Alters Skin Ceramides and Compromises the Skin Barrier in Ears (2022)
  • Author(s): Tan Kahbing Jasmine、Nakamizo Satoshi、Lee-Okada Hyeon-Cheol、Sato Reiko、Chow Zachary、Nakajima Saeko、Common John E.A.、Saeki Kazuko、Yokomizo Takehiko、Ginhoux Florent、Kabashima Kenji
  • Journal Title: Journal of Investigative Dermatology Volume: - Issue: 7 Pages: 2020-2023.e2
  • DOI: 10.1016/j.jid.2021.12.017
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification and characterization of bioactive metabolites of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2 (2022)
  • Author(s): Yasukawa K., Okuno T., Ogawa N., Kobayashi Y., Yokomizo T.
  • Journal Title: Journal of Biochemistry Volume: 173 Issue: 4 Pages: 293-305
  • DOI: 10.1093/jb/mvac105
  • Peer Reviewed / Open Access
• [Journal Article] Cutaneous Liver X Receptor Activation Prevents the Formation of Imiquimod-Induced Psoriatic Dermatitis. (2021)
  • Author(s): Otsuka M., Egawa G., Dainichi T., Okuno T., Ishida Y., Chow Z., Asahina R., Miyake T., Nomura T., Kitoh A., Yokomizo T., Kabashima K.
  • Journal Title: Journal of Investigative Dermatology Volume: 142(4) Issue: 4 Pages: 1233-1237.e1
  • DOI: 10.1016/j.jid.2021.08.432
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The c‐terminal region of BLT2 restricts its localization to the lateral membrane in a LIN7C‐dependent manner (2021)
  • Author(s): Hara Takuya、Saeki Kazuko、Jinnouchi Hiromi、Kazuno Saiko、Miura Yoshiki、Yokomizo Takehiko
  • Journal Title: The FASEB Journal Volume: 35 Issue: 2 Pages: 21364-21364
  • DOI: 10.1096/fj.202002640r
  • Peer Reviewed
• [Journal Article] FADS2 ablation exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid-depleted mice (2021)
  • Author(s): Y. Hayashi, HC. Lee-Okada, E. Nakamura, N. Tada, T. Yokomizo, Y. Fujiwara, I. Ichi
  • Journal Title: FEBS letters Volume: Accepted Issue: 14 Pages: 1920-1932
  • DOI: 10.1002/1873-3468.14134
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Development of a liquid chromatography?electrospray ionization tandem mass spectrometric method for the simultaneous analysis of free fatty acids (2021)
  • Author(s): Lee-Okada Hyeon-Cheol、Hama Kotaro、Yokoyama Kazuaki、Yokomizo Takehiko
  • Journal Title: The Journal of Biochemistry Volume: 170 Issue: 3 Pages: 389-397
  • DOI: 10.1093/jb/mvab054
  • NAID: 40022721885
  • Peer Reviewed / Open Access
• [Journal Article] Biosynthetic Crossover of 5-Lipoxygenase and Cyclooxygenase-2 Yields 5-Hydroxy-PGE2 and 5-Hydroxy-PGD2. (2021)
  • Author(s): Nakashima F., Suzuki T., Gordon O.N., Golding D., Okuno T., Gimenez-Bastida J.A., Yokomizo T., Schneider C.
  • Journal Title: JACS Au Volume: 1(9) Issue: 9 Pages: 1380-1388
  • DOI: 10.1021/jacsau.1c00177
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Trimebutine suppresses Toll-like receptor 2/4/7/8/9 signaling pathways in macrophages (2021)
  • Author(s): Ogawa Natsumi、Nakajima Shingo、Tamada Kenya、Yokoue Natsuki、Tachibana Haruki、Okazawa Miwa、Oyama Takahiro、Abe Hideaki、Yamazaki Hiroaki、Yoshimori Atsushi、Sato Akira、Kamiya Takanori、Yokomizo Takehiko、Uchiumi Fumiaki、Abe Takehiko、Tanuma Sei-ichi
  • Journal Title: Archives of Biochemistry and Biophysics Volume: 711 Pages: 109029-109029
  • DOI: 10.1016/j.abb.2021.109029
  • Peer Reviewed
• [Journal Article] Eicosanoid profiling in patients with complete form of pachydermoperiostosis carrying SLCO2A1 mutations. (2021)
  • Author(s): Oiwa T., Ishibashi M., Okuno T., Ohba M., Endo Y., Uozumi R., Ghazawi F.M., Yoshida K., Niizeki H., Yokomizo T., Nomura T., Kabashima K.
  • Journal Title: Journal of Dermatology Volume: 48(9) Issue: 9 Pages: 1442-1446
  • DOI: 10.1111/1346-8138.16012
  • Peer Reviewed
• [Journal Article] Metabolism and biological functions of 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (2021)
  • Author(s): Okuno Toshiaki、Yokomizo Takehiko
  • Journal Title: Prostaglandins & Other Lipid Mediators Volume: 152 Pages: 106502-106502
  • DOI: 10.1016/j.prostaglandins.2020.106502
  • Peer Reviewed
• [Journal Article] Sphingosine 1-Phosphate (S1P) in the Peritoneal Fluid Skews M2 Macrophage and Contributes to the Development of Endometriosis. (2021)
  • Author(s): Ono Y., Kawakita T., Yoshino O., Sato E., Kano K., Ohba M., Okuno T., Ito M., Koga K., Honda M., Furue A., Hiraoka T., Wada S., Iwasa T., Yokomizo T., Aoki J., Maeda N., Unno N., Osuga Y., Hirata S.
  • Journal Title: Biomedicines Volume: 9(11) Issue: 11 Pages: 1519-1519
  • DOI: 10.3390/biomedicines9111519
  • Peer Reviewed / Open Access
• [Journal Article] Dietary intake of n-3 polyunsaturated fatty acids alters the lipid mediator profile of the kidney but does not attenuate renal insufficiency. (2021)
  • Author(s): Shioda R., Jo-Watanabe A., Lee-Okada H.C., Yasukawa K., Okuno T., Suzuki Y., Yokomizo T.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 582 Pages: 49-56
  • DOI: 10.1016/j.bbrc.2021.10.028
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of both cyclooxygenase-1 and -2 promotes epicutaneous Th2 and Th17 sensitization and allergic airway inflammation on subsequent airway exposure to protease allergen in mice (2021)
  • Author(s): Suchiva, P., Takai, T., Kamijo, S., Maruyama, N., Yokomizo, T., Sugimoto, Y., Okumura, K., Ikeda, S., Ogawa, H.
  • Journal Title: International Archives of Allergy and Immunology Volume: - Issue: 9 Pages: 788-799
  • DOI: 10.1159/000514975
  • Peer Reviewed / Open Access
• [Journal Article] Up-regulation of cytosolic prostaglandin E synthase in fetal-membrane and amniotic prostaglandin E2 accumulation in labor (2021)
  • Author(s): Nanase Takahashi, Toshiaki Okuno, Hiroki Fujii, Shintaro Makino, Masaya Takahashi, Mai Ohba, Kazuko Saeki, Atsuo Itakura, Satoru Takeda, Takehiko Yokomizo
  • Journal Title: PLoS One Volume: 16 Issue: 4 Pages: e0250638-e0250638
  • DOI: 10.1371/journal.pone.0250638
  • Peer Reviewed / Open Access
• [Journal Article] Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation. (2020)
  • Author(s): Tomoaki Koga, Fumiyuki Sasaki, Kazuko Saeki, Soken Tsuchiya, Toshiaki Okuno, Mai Ohba, Takako Ichiki, Satoshi Iwamoto, Hirotsugu Uzawa, Keiko Kitajima, Chikara Meno, Eri Nakamura, Norihiro Tada, Yoshinori Fukui, Junichi Kikuta, Masaru Ishii, Yukihiko Sugimoto, and Mitsuyoshi Nakao, Takehiko Yokomizo.
  • Journal Title: Cellular & Molecular Immunology Volume: 8 Issue: 6 Pages: 1-13
  • DOI: 10.1038/s41423-020-00559-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 高度不飽和脂肪酸の生理機能の解明に向けた動物モデルの作製と応用 (2023)
  • Author(s): 李賢哲, 横溝岳彦
  • Organizer: 第65回日本脂質生化学会
• [Presentation] FADS1/2二重欠損マウスを用いた新規PUFA欠乏モデルの開発 (2023)
  • Author(s): 安藤美沙, 李賢哲, 佐々木崇晴, 横溝岳彦
  • Organizer: 第65回日本脂質生化学会
• [Presentation] 細胞質型ホスホリパーゼcPLA2ζは皮膚の創傷治癒を促進する脂質を動員する. (2023)
  • Author(s): 長崎祐樹, 武富芳隆, 三木寿美, 安川賢, 佐伯和子, 横溝岳彦, 山本登志子, 村上誠.
  • Organizer: 第96回日本生化学会
• [Presentation] 重篤な脂肪肝を引き起こす高度不飽和脂肪酸欠乏モデルマウスの開発 (2023)
  • Author(s): 安藤美沙, 李賢哲, 佐々木崇晴, 横溝岳彦
  • Organizer: 第96回日本生化学会
• [Presentation] 精子形成における脂肪酸輸送体 (FATP1)の役割の解明 (2023)
  • Author(s): 陣内ひろみ, 佐伯和子, 中村衣里, 多田昇弘, 李賢哲, 横溝岳彦
  • Organizer: 第96回日本生化学会
• [Presentation] ケミカルツールを用いたリゾリン脂質分解酵素の探索および解析 (2023)
  • Author(s): 李賢哲, 花田剛郎, 横溝岳彦
  • Organizer: 第96回日本生化学会
• [Presentation] ロイコトリエンB4第2受容体BLT2を活性化する腸内細菌由来脂肪酸代謝物の探索の保護的役割 (2023)
  • Author(s): 城(渡辺)愛理, 佐藤智子, 岸野重信, 小川順, 横溝岳彦
  • Organizer: 第96回日本生化学会
• [Presentation] 高度不飽和脂肪酸の欠乏が引き起こす貧血のメカニズムの解明 (2023)
  • Author(s): 佐伯和子, 李賢哲, 横溝岳彦
  • Organizer: 第96回日本生化学会
• [Presentation] マウスドライアイモデルの点状表層角膜症の堅牢で客観的な評価方法の開発 (2023)
  • Author(s): 藤井寛紀, 佐伯 和., 星崇仁, 門屋悠里, 大鹿哲郎, 横溝岳彦
  • Organizer: 第43回日本眼薬理学会
• [Presentation] The protective role of 12-HHT/BLT2 axis on the plasma membrane disruption-induced cell damage. (2023)
  • Author(s): 遅源, 佐伯和子, 横溝岳彦
  • Organizer: 第46回日本分子生物学会年会
• [Presentation] The roles of polyunsaturated fatty acids in vivo revealed by analyzing polyunsaturated fatty acid-deficient mice. (2023)
  • Author(s): Yokomizo T.
  • Organizer: 63th ICBL, International Conference on the Bioscience of Lipids
  • Int'l Joint Research / Invited
• [Presentation] The roles of polyunsaturated fatty acids in vivo. (2023)
  • Author(s): Yokomizo T.
  • Organizer: 26th Bomun Synposium
  • Int'l Joint Research / Invited
• [Presentation] アレルギー疾患・免疫疾患における脂質メディエーターの役割 (2023)
  • Author(s): 横溝岳彦
  • Organizer: 第72回日本アレルギー学会学術大会
  • Invited
• [Presentation] 高度不飽和脂肪酸の新しい役割 (2023)
  • Author(s): 横溝岳彦
  • Organizer: 第96回日本生化学会
  • Invited
• [Presentation] Yokomizo TThe roles of leukotriene B4/BLT1 axis in immune complex-mediated glomerulonephritis17th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases, (2022)
  • Author(s): Yokomizo T
  • Organizer: 17th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases, Symposium
  • Int'l Joint Research / Invited
• [Presentation] The leukotriene B4/BLT1-dependent neutrophil accumulation exacerbates immune complex-mediated glomerulonephritis (2022)
  • Author(s): Yokomizo T, Shioda R, Okuno T, Nakayama M, Suzuki Y , Jo-Watanabe A
  • Organizer: 62th ICBL, International Conference on the Bioscience of Lipids, Invited lecture
  • Int'l Joint Research / Invited
• [Presentation] New roles of bioactive lipids and unsaturated fatty acids in vivo (2022)
  • Author(s): Yokomizo T
  • Organizer: 11th International Singapore Lipid Symposium (iSLS) Singapore
  • Int'l Joint Research / Invited
• [Presentation] 12-HHT/BLT2 axis promotes cell membrane repair and protects epithelial cells from pore-forming toxin-induced cell death (2022)
  • Author(s): Chi Y, Saeki K , Yokomizo T
  • Organizer: 62th ICBL, International Conference on the Bioscience of Lipids
  • Int'l Joint Research
• [Presentation] Discovery of 5-hydroxy- prostaglandin (2022)
  • Author(s): Nakanishi F, Suzuki T, Gordon ON, Golding D, Okuno T, Gimenez-Bastida J, Yokomizo T , Schneider C
  • Organizer: 17th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases, Symposium
  • Int'l Joint Research
• [Presentation] The leukotriene B4-BLT1 axis in neutrophils exacerbates crescentic glomerulonephritis. (2022)
  • Author(s): Oh-hora M, Shioda R, Jo-Watanabe A, Okuno T, Saeki K, Nakayama M, Suzuki Y , Yokomizo T
  • Organizer: 第51回日本免疫学会学術集会
• [Presentation] Cellular senescence affects secretary phenotype and myogenic differentiation in mouse myoblasts (2022)
  • Author(s): Ono T, Jo-Watanabe A , Yokomizo T
  • Organizer: 第45回日本基礎老化学会大会
• [Presentation] Identification of the pathological mechanism of glomerulonephritis by the LTB4-BLT1 axis and its application to therapy (2022)
  • Author(s): Shioda R, Jo-Watanabe A, Okuno T, Nakayama M, Yokomizo T , Suzuki Y
  • Organizer: World Congress of Nephrology (WCN) WCN’22
  • Int'l Joint Research
• [Presentation] Leukotriene B4-BLT1-dependent neutrophil recruitment contributes to the pathogenesis of crescent glomerulonephritis. (2022)
  • Author(s): Shioda R, Jo-Watanabe A, Okuno T, Yokomizo T , Suzuki Y
  • Organizer: 第11回CKD frontier
• [Presentation] 10T1/2細胞における脂肪細胞内ホルモン感受性リパーゼ（HSL）の 調節メカニズムの研究 (2022)
  • Author(s): 呂詩萌, 李賢哲 , 横溝岳彦
  • Organizer: 第64回日本脂質生化学会
• [Presentation] C型肝炎治療薬ソホスブビルはホルモン感受性リパーゼを阻害する (2022)
  • Author(s): 李賢哲, 伊志嶺百々子, 數野彩子, 高ひかり, 三浦芳樹 , 横溝岳彦
  • Organizer: 第64回日本脂質生化学会
• [Presentation] ProTideプロドラッグによる内在性セリン加水分解酵素阻害 (2022)
  • Author(s): 李賢哲 , 横溝岳彦
  • Organizer: 日本ケミカルバイオロジー学会第16回年会
• [Presentation] HDSFはLYPLA1およびLYPLA2の活性を阻害する (2022)
  • Author(s): 花田剛郎, 李賢哲 , 横溝岳彦
  • Organizer: 第64回日本脂質生化学会
• [Presentation] 膜孔形成毒素による上皮細胞障害に対するBLT2の保護的役割 (2022)
  • Author(s): 遅源, 佐伯和子 , 横溝岳彦
  • Organizer: 第64回日本脂質生化学会
• [Presentation] 細胞質型ホスホリパーゼ cPLA2ζは皮膚の適応修復に関わる (2022)
  • Author(s): 長崎祐樹, 武富芳隆, 三木寿美, 安川賢, 佐伯和子, 横溝岳彦, 山本登志子 , 村上誠
  • Organizer: 第95回日本生化学会
• [Presentation] 雄性生殖における脂肪酸輸送体 (FATP1)の役割の解明 (2022)
  • Author(s): 陣内ひろみ, 佐伯和子, 中村衣里, 多田昇弘, 李賢哲 , 横溝岳彦
  • Organizer: 第95回日本生化学会
• [Presentation] 精子における脂肪酸輸送体 (FATP1)の役割の解明 (2022)
  • Author(s): 陣内ひろみ, 佐伯和子, 中村衣里, 多田昇弘, 李賢哲 , 横溝岳彦.
  • Organizer: 第64回日本脂質生化学会
• [Presentation] A critical role of transient receptor melastatin 7 in early T cell development (2021)
  • Author(s): Oh-hora M , Yokomizo T
  • Organizer: 第50回日本免疫学会学術集会
• [Presentation] Leukotriene B4-BLT1 axis controls neutrophil accumulation via Fcγ receptor-dependent leukotriene B4 production in experimental glomerulonephritis (2021)
  • Author(s): Shioda R, Jo-Watanabe A, Okuno T, Nakayama M, Yokomizo T , Suzuki Y
  • Organizer: American Society of Nephrology(ASN) Kidney Week 2021
  • Int'l Joint Research
• [Presentation] ロイコトリエンB4受容体BLT1の発現で規定される炎症性樹状細胞の機能解析 (2021)
  • Author(s): 古賀友紹, 横溝岳彦 , 中尾光善
  • Organizer: 東京呼吸器リサーチフォーラム
• [Presentation] LTB4-BLT1軸による糸球体腎炎の病態制御機構の解明と治療への応用 (2021)
  • Author(s): 塩田遼太郎, 城愛理, 奥野利明, 鈴木祐介 , 横溝岳彦
  • Organizer: 第94回日本生化学会
• [Presentation] ロイコトリエンB4-BLT1軸はFcγ受容体依存的に腎炎急性期の好中球浸潤を制御する (2021)
  • Author(s): 塩田遼太郎, 城愛理, 奥野利明, 鈴木祐介 , 横溝岳彦
  • Organizer: 第63回日本脂質生化学会
• [Presentation] ロイコトリエンB4-BLT1軸はFcγ受容体依存的に腎炎急性期の好中球浸潤を制御する (2021)
  • Author(s): 塩田遼太郎, 城愛理, 横溝岳彦 , 鈴木祐介
  • Organizer: 第64回日本腎臓学会学術総会
• [Presentation] cPLA2εは複数組織において抗炎症性脂質NAEの産生に関わる (2021)
  • Author(s): 杉本奈央, 高宮里奈, 三木寿美, 宇山徹, 上田夏生, 李賢哲, 横溝岳彦 , 村上誠
  • Organizer: 第94回日本生化学会
• [Presentation] Protective roles of leukotriene B4 receptor type 2 on pore forming toxin-induced cell membrane damage (2021)
  • Author(s): 遅源, 佐伯和子 , 横溝岳彦
  • Organizer: 第94回日本生化学会
• [Presentation] Leukotriene B4 receptor type 2 enhances cell membrane repair and protects cell death caused by pore forming agent. (2021)
  • Author(s): 遅源, 佐伯和子 , 横溝岳彦
  • Organizer: 第8回日本細胞外小胞学会学術集会
• [Book] ビジュアル パニーニ臨床生化学（原書第2版） (2023)
  • Author(s): 横溝岳彦
  • Total Pages: 544
  • Publisher: 南江堂
  • ISBN: 9784524232871
• [Remarks] 順天堂大学医学研究科 生化学・細胞機能制御学のホームページ
  • URL: https://sites.google.com/view/jbio1/
• [Remarks] プレスリリース 重炭酸イオンを感知するGタンパク質共役型受容体の発見
  • URL: https://www.juntendo.ac.jp/news/17662.html
• [Remarks] Innovative Therapies for Ischemic Stroke
  • URL: https://en.juntendo.ac.jp/highlights/news/nid290
• [Remarks] プレスリリース：オメガ６脂肪酸の男性ホルモン産生における役割を解明
  • URL: https://www.juntendo.ac.jp/news/20220927-01.html
• [Remarks] プレスリリース：半月体形成性糸球体腎炎発症におけるロイコトリエンB4の役割を解明
  • URL: https://www.juntendo.ac.jp/news/20230125-01.html
• [Remarks] プレスリリース：双極性障害の躁・うつの両方の症状を示す世界初の動物モデルの作製に成功
  • URL: https://www.juntendo.ac.jp/news/20230221-01.html
• [Remarks] 順天堂大学医学部生化学第一講座
  • URL: http://plaza.umin.ac.jp/j_bio/