| Budget Amount *help |
¥41,860,000 (Direct Cost: ¥32,200,000、Indirect Cost: ¥9,660,000)
Fiscal Year 2024: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2023: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2022: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2021: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
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| Outline of Final Research Achievements |
In this study, we demonstrated that a novel form of respiration using the intestine, known as "intestinal ventilation," is feasible in mammals through a liquid oxygen delivery model in animals, and elucidated its molecular and cellular mechanisms. Furthermore, we successfully engineered ectopic intestines capable of receiving liquid oxygen using human iPSC-derived rectal organoids. These findings suggest the potential of this approach as an innovative technology to provide a new means of oxygen supply in cases of severe respiratory failure.
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