• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Roles of a mitochondrial respiratory supercomplex assembly factor Cox7rp in cells, organs and health

Research Project

Project/Area Number 21H04829
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

Inoue Satoshi  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (40251251)

Co-Investigator(Kenkyū-buntansha) 池田 和博  埼玉医科大学, 医学部, 准教授 (30343461)
Project Period (FY) 2021-04-05 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥42,250,000 (Direct Cost: ¥32,500,000、Indirect Cost: ¥9,750,000)
Fiscal Year 2023: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2022: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2021: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Keywordsミトコンドリア / 呼吸鎖複合体 / 健康長寿 / 超複合体 / エネルギー代謝 / 長寿 / ミトコンドリア呼吸鎖超複合体 / FRET / 筋肉 / 呼吸鎖超複合体
Outline of Research at the Start

ミトコンドリアは、近年提唱された呼吸鎖超複合体を形成しながら、エネルギーを産生し、多くの細胞内代謝経路を統括する。本研究では、 Cox7rpが超複合体形成の鍵分子であることを解明した実績に基づき、超複合体における構造状態と機能の関係、制御メカニズム、疾患と寿命での役割の解明を目的に、定量評価法と小分子創薬、可視化法開発を推進する。独自のCox7rp遺伝子改変動物モデルを活用し、ヒト組織検体を用いた実証研究に発展させ、ミトコンドリア超複合体が標的臓器への作用を介して長寿シグナルに与える役割と、新たな疾患メカニズムを明らかにし、その制御に基づく新規治療法開発への応用を図る。

Outline of Final Research Achievements

Mitochondria play a crucial role as the cell organelles efficiently generate ATP and function in homeostasis and aging process. Mitochondrial respiratory chain (MRC) complexes (I, II, III, and IV) are essential components, and higher-order MRC supercomplexes consisting of I, III, and IV particularly contribute to efficient respiratory ability and metabolic adaptation. We elucidated that Cox7rp functions as a regulator of MRC supercomplex formation, proposing a role of MRC supercomplex in age-related diseases. In the present study, we labeled MRC complexes and visualized supercomplex formation in living cells by observing the FRET phenomenon. We successfully evaluated and quantified the level of MRC supercomplex, and chemical screening based on this FRET technology discovered specific compounds that enhance mitochondrial respiration [Nature Communications 2023]. We also studied MRC supercomplex assembly factors as well as roles of Cox7rp in vivo using knockout and transgenic mice.

Academic Significance and Societal Importance of the Research Achievements

ミトコンドリアは、近年提唱された呼吸鎖超複合体を形成しながら、エネルギーを産生し、多くの細胞内代謝経路を統括する。本研究では、 Cox7rpが超複合体形成の鍵分子であることを解明した実績に基づき、超複合体における構造状態と機能の関係、制御メカニズム、疾患での役割を明らかにし、可視化定量法開発と小分子創薬を推進した。独自のCox7rp遺伝子改変動物モデルを活用し、ミトコンドリア超複合体が標的臓器への作用を介して代謝シグナルに与える役割と、新たな疾患メカニズムを明らかにし、その制御に基づく新規治療法開発への応用を提言した。論文・学会発表と知財の獲得も順調に進んでおり、今後の研究の発展が期待できる。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Comments on the Screening Results   Annual Research Report
  • Research Products

    (58 results)

All 2024 2023 2022 2021

All Journal Article (28 results) (of which Peer Reviewed: 28 results,  Open Access: 28 results) Presentation (27 results) (of which Int'l Joint Research: 1 results,  Invited: 9 results) Book (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] EBAG9-deficient mice display decreased bone mineral density with suppressed autophagy2024

    • Author(s)
      Azuma Kotaro、Ikeda Kazuhiro、Shiba Sachiko、Sato Wataru、Horie Kuniko、Hasegawa Tomoka、Amizuka Norio、Tanaka Shinya、Inoue Satoshi
    • Journal Title

      iScience

      Volume: 27 Issue: 2 Pages: 108871-108871

    • DOI

      10.1016/j.isci.2024.108871

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of RNA binding proteins of the <i>Drosophila</i> behavior and human splicing (DBHS) family in health and cancer2024

    • Author(s)
      Takeiwa Toshihiko、Ikeda Kazuhiro、Horie Kuniko、Inoue Satoshi
    • Journal Title

      RNA Biology

      Volume: 21 Issue: 1 Pages: 1-17

    • DOI

      10.1080/15476286.2024.2332855

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vitamin K insufficiency predicts incidence of frailty in community-dwelling older adults: The Otassha Study2023

    • Author(s)
      Azuma Kotaro、Osuka Yosuke、Kojima Narumi、Sasai Hiroyuki、Inoue Satoshi
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: 41 Issue: 6 Pages: 817-821

    • DOI

      10.1007/s00774-023-01457-4

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of small-molecule inhibitors against the interaction of RNA-binding protein PSF and its target RNA for cancer treatment2023

    • Author(s)
      Takayama Ken-ichi、Matsuoka Seiji、Adachi Shungo、Honma Teruki、Yoshida Masahito、Doi Takayuki、Shin-ya Kazuo、Yoshida Minoru、Osada Hiroyuki、Inoue Satoshi
    • Journal Title

      PNAS Nexus

      Volume: 2 Issue: 6 Pages: 208-208

    • DOI

      10.1093/pnasnexus/pgad203

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stress granules sequester Alzheimer’s disease-associated gene transcripts and regulate disease-related neuronal proteostasis2023

    • Author(s)
      Sato Kaoru、Takayama Ken-ichi、Inoue Satoshi
    • Journal Title

      Aging

      Volume: 15 Issue: 10 Pages: 3984-4011

    • DOI

      10.18632/aging.204737

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stress granule‐mediated <scp>RNA</scp> regulatory mechanism in Alzheimer's disease2023

    • Author(s)
      Sato Kaoru、Takayama Ken‐ichi、Inoue Satoshi
    • Journal Title

      Geriatrics &amp; Gerontology International

      Volume: 24 Issue: S1 Pages: 7-14

    • DOI

      10.1111/ggi.14663

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression and function of estrogen receptors and estrogen-related receptors in the brain and their association with Alzheimer’s disease2023

    • Author(s)
      Sato Kaoru、Takayama Ken-ichi、Inoue Satoshi
    • Journal Title

      Frontiers in Endocrinology

      Volume: 14 Pages: 1220150-1220150

    • DOI

      10.3389/fendo.2023.1220150

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of Noncoding RNAs in Regulation of Mitochondrial Electron Transport Chain and Oxidative Phosphorylation2023

    • Author(s)
      Kobayashi Ami、Takeiwa Toshihiko、Ikeda Kazuhiro、Inoue Satoshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 11 Pages: 9414-9414

    • DOI

      10.3390/ijms24119414

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of DNA damage response-related genes as biomarkers for castration-resistant prostate cancer2023

    • Author(s)
      Oshima Masashi、Takayama Ken-ichi、Yamada Yuta、Kimura Naoki、Kume Haruki、Fujimura Tetsuya、Inoue Satoshi
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 19602-19602

    • DOI

      10.1038/s41598-023-46651-6

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] G-protein signaling of oxytocin receptor as a potential target for cabazitaxel-resistant prostate cancer2023

    • Author(s)
      Hongo Hiroshi、Kosaka Takeo、Takayama Ken-Ichi、Baba Yuto、Yasumizu Yota、Ueda Koji、Suzuki Yutaka、Inoue Satoshi、Beltran Himisha、Oya Mototsugu
    • Journal Title

      PNAS Nexus

      Volume: 3 Issue: 1 Pages: 002-002

    • DOI

      10.1093/pnasnexus/pgae002

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of piRNA biogenesis and its neuronal function in the development of neurodegenerative diseases2023

    • Author(s)
      Sato Kaoru、Takayama Ken-ichi、Inoue Satoshi
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 15 Pages: 1157818-1157818

    • DOI

      10.3389/fnagi.2023.1157818

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Editorial: Interplay between epigenetic modifiers and transcription factors in driving cancer progression2023

    • Author(s)
      Yang Yongyong、Di Ruscio Annalisa、Inoue Satoshi、Wang Guocan、Gao Shuai
    • Journal Title

      Frontiers in Oncology

      Volume: 13 Pages: 1211537-1211537

    • DOI

      10.3389/fonc.2023.1211537

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A FRET-based respirasome assembly screen identifies spleen tyrosine kinase as a target to improve muscle mitochondrial respiration and exercise performance in mice2023

    • Author(s)
      Kobayashi Ami、Azuma Kotaro、Takeiwa Toshihiko、Kitami Toshimori、Horie Kuniko、Ikeda Kazuhiro、Inoue Satoshi
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 36697396-36697396

    • DOI

      10.1038/s41467-023-35865-x

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of Estrogen, Estrogen Receptors, and Estrogen-Related Receptors in Skeletal Muscle: Regulation of Mitochondrial Function2023

    • Author(s)
      Yoh Kenta、Ikeda Kazuhiro、Horie Kuniko、Inoue Satoshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 3 Pages: 1853-1853

    • DOI

      10.3390/ijms24031853

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PSPC1 is a potential prognostic marker for hormone-dependent breast cancer patients and modulates RNA processing of ESR1 and SCFD22022

    • Author(s)
      Takeiwa Toshihiko、Ikeda Kazuhiro、Suzuki Takashi、Sato Wataru、Iino Kaori、Mitobe Yuichi、Kawabata Hidetaka、Horie Kuniko、Inoue Satoshi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 9495-9495

    • DOI

      10.1038/s41598-022-13601-7

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] OCT1-target neural gene PFN2 promotes tumor growth in androgen receptor-negative prostate cancer2022

    • Author(s)
      Obinata Daisuke、Funakoshi Daigo、Takayama Kenichi、Hara Makoto、Niranjan Birunthi、Teng Linda、Lawrence Mitchell G.、Taylor Renea A.、Risbridger Gail P.、Suzuki Yutaka、Takahashi Satoru、Inoue Satoshi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 6094-6094

    • DOI

      10.1038/s41598-022-10099-x

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ribonuclease H2 Subunit A Preserves Genomic Integrity and Promotes Prostate Cancer Progression2022

    • Author(s)
      Kimura Naoki、Takayama Ken-ichi、Yamada Yuta、Kume Haruki、Fujimura Tetsuya、Inoue Satoshi
    • Journal Title

      Cancer Research Communications

      Volume: 2 Issue: 8 Pages: 870-883

    • DOI

      10.1158/2767-9764.crc-22-0126

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Testis-expressed gene 11 inhibits cisplatin-induced DNA damage and contributes to chemoresistance in testicular germ cell tumor2022

    • Author(s)
      Kitayama Sachi、Ikeda Kazuhiro、Sato Wataru、Takeshita Hideki、Kawakami Satoru、Inoue Satoshi、Horie Kuniko
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 18423-18423

    • DOI

      10.1038/s41598-022-21856-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Estrogen-Inducible LncRNA BNAT1 Functions as a Modulator for Estrogen Receptor Signaling in Endocrine-Resistant Breast Cancer Cells2022

    • Author(s)
      Horie Kuniko、Takagi Kiyoshi、Takeiwa Toshihiko、Mitobe Yuichi、Kawabata Hidetaka、Suzuki Takashi、Ikeda Kazuhiro、Inoue Satoshi
    • Journal Title

      Cells

      Volume: 11 Issue: 22 Pages: 3610-3610

    • DOI

      10.3390/cells11223610

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reconsideration of Alzheimer’s Disease Therapy from a Viewpoint of Amyloidogenic Evolvability2022

    • Author(s)
      Ho Gilbert、Choo Pei Chen、Waragai Masaaki、Inoue Satoshi、Masliah Eliezer、Hashimoto Makoto
    • Journal Title

      Journal of Alzheimer's Disease Reports

      Volume: 6 Issue: 1 Pages: 207-210

    • DOI

      10.3233/adr-210021

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeting phase separation on enhancers induced by transcription factor complex formations as a new strategy for treating drug-resistant cancers2022

    • Author(s)
      Takayama Ken-ichi、Inoue Satoshi
    • Journal Title

      Frontiers in Oncology

      Volume: 12 Pages: 1024600-1024600

    • DOI

      10.3389/fonc.2022.1024600

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emerging Roles of COX7RP and Mitochondrial Oxidative Phosphorylation in Breast Cancer2022

    • Author(s)
      Kamada Shuhei、Takeiwa Toshihiko、Ikeda Kazuhiro、Horie Kuniko、Inoue Satoshi
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 10 Pages: 717881-717881

    • DOI

      10.3389/fcell.2022.717881

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aging-associated stem/progenitor cell dysfunction in the salivary glands of mice2021

    • Author(s)
      Takamatsu Koki、Tanaka Junichi、Katada Ryogo、Azuma Kotaro、Takakura Ikuko、Aota Keiko、Kamatani Takaaki、Shirota Tatsuo、Inoue Satoshi、Mishima Kenji
    • Journal Title

      Experimental Cell Research

      Volume: 409 Issue: 1 Pages: 112889-112889

    • DOI

      10.1016/j.yexcr.2021.112889

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRIM47 activates NF-κB signaling via PKC-ε/PKD3 stabilization and contributes to endocrine therapy resistance in breast cancer2021

    • Author(s)
      Azuma Kotaro、Ikeda Kazuhiro、Suzuki Takashi、Aogi Kenjiro、Horie-Inoue Kuniko、Inoue Satoshi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 118 Issue: 35

    • DOI

      10.1073/pnas.2100784118

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer2021

    • Author(s)
      Takayama Ken-ichi、Kosaka Takeo、Suzuki Takashi、Hongo Hiroshi、Oya Mototsugu、Fujimura Tetsuya、Suzuki Yutaka、Inoue Satoshi
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 3766-3766

    • DOI

      10.1038/s41467-021-23974-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicopathological and Preclinical Patient-Derived Model Studies Define High Expression of NRN1 as a Diagnostic and Therapeutic Target for Clear Cell Renal Cell Carcinoma2021

    • Author(s)
      Kamada Shuhei、Ikeda Kazuhiro、Suzuki Takashi、Sato Wataru、Kitayama Sachi、Kawakami Satoru、Ichikawa Tomohiko、Horie Kuniko、Inoue Satoshi
    • Journal Title

      Frontiers in Oncology

      Volume: 11 Pages: 758503-758503

    • DOI

      10.3389/fonc.2021.758503

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeting Epigenetic and Posttranscriptional Gene Regulation by PSF Impairs Hormone Therapy-Refractory Cancer Growth2021

    • Author(s)
      Takayama Ken-ichi、Honma Teruki、Suzuki Takashi、Kondoh Yasumitsu、Osada Hiroyuki、Suzuki Yutaka、Yoshida Minoru、Inoue Satoshi
    • Journal Title

      Cancer Research

      Volume: 81 Issue: 13 Pages: 3495-3508

    • DOI

      10.1158/0008-5472.can-20-3819

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vitamin K-dependent γ-glutamyl carboxylase in Sertoli cells is essential for male fertility in mice.2021

    • Author(s)
      Sachiko Shiba, Kazuhiro Ikeda, Kuniko Horie-Inoue, Kotaro Azuma, Tomoka Hasegawa, Norio Amizuka, Tomoaki Tanaka, Toshihiko Takeiwa, Yasuaki Shibata, Takehiko Koji, Satoshi Inoue
    • Journal Title

      Mol Cell Biol.

      Volume: 41(4) Issue: 4 Pages: 404-20

    • DOI

      10.1128/mcb.00404-20

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] エストロゲン関連受容体とミトコンドリア呼吸鎖超複合体形成因子COX7RPの前立腺がんにおける役割2023

    • Author(s)
      池田和博、鈴木貴、堀江公仁子、井上聡
    • Organizer
      第31回日本ステロイドホルモン学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 核内受容体に制御されるミトコンドリア遺伝子 COX7RP は酸素呼吸を促進してホルモン依存性がんの病態進行に関わる2023

    • Author(s)
      堀江公仁子、池田和博、井上聡
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 前立腺がんにおけるミトコンドリア呼吸鎖超複合体形成促進因子COX7RPを介するエネルギー代謝制御と患者予後における役割2023

    • Author(s)
      池田和博、堀江公仁子、井上聡
    • Organizer
      第4回オール埼玉医大研究の日
    • Related Report
      2023 Annual Research Report
  • [Presentation] フレイル・サルコペニアの最先端基礎研究:ミトコンドリア超複合体と筋機能2023

    • Author(s)
      東浩太郎、竹岩俊彦、池田和博、井上聡
    • Organizer
      第10回日本サルコペニア・フレイル学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ミトコンドリア呼吸鎖超複合体の健康長寿における役割とそのライブセルイメージング法の開発2023

    • Author(s)
      井上聡
    • Organizer
      第96回日本生化学会大会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 分子内のエチレングリコールの数が新規呼吸鎖複合体I阻害剤9bwの機能に与える影響2023

    • Author(s)
      藤原恭子、関本和祥、廣田大樹、神戸洸哉、金城はなか、小林佑朔、松田大聖、村上瑞希、坂口陸、佐藤睦、長崎瑛里、池田和博、高山賢一、井上聡、大月穣
    • Organizer
      第82回日本癌学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 呼吸鎖超複合体のライブイメージング法開発と筋肉機能向上・サルコペニア治療への応用2023

    • Author(s)
      竹岩俊彦、東浩太郎、池田和博、堀江公仁子、井上聡
    • Organizer
      第9回日本筋学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ミトコンドリア呼吸鎖超複合体と筋機能2023

    • Author(s)
      井上聡
    • Organizer
      第41回日本骨代謝学会学術集会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 難治性前立腺がんにおけるミトコンドリア呼吸鎖超複合体形成因子COX7RPの役割とその上流転写因子のエストロゲン関連受容体ERRαによる発現制御機構2023

    • Author(s)
      池田和博、鈴木貴、堀江公仁子、井上聡
    • Organizer
      日本アンドロロジー学会第42回学術大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ミトコンドリア呼吸鎖超複合体の生細胞FRETイメージング法開発とサルコペニア治療・筋肉抗老化への応用2023

    • Author(s)
      竹岩俊彦、東浩太郎、池田和博、堀江公仁子、井上聡
    • Organizer
      第46回日本基礎老化学会大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 疫と骨免疫に関わる新しい因子EBAG92023

    • Author(s)
      井上聡
    • Organizer
      第23回日本抗加齢医学会総会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] がん代謝を調節するミトコンドリア呼吸鎖超複合体形成因子COX7RPの前立腺がんにおける役割とその核内受容体ERRαと転写共役因子PGC-1αによる発現制御機構2023

    • Author(s)
      池田和博, 鈴木貴, 堀江公仁子, 井上聡
    • Organizer
      第9回 がんと代謝研究会 in 松山
    • Related Report
      2023 Annual Research Report
  • [Presentation] Stress granules sequester Alzheimer’s disease-associated gene transcripts in human neuronal cells.2023

    • Author(s)
      Sato K, Takayama K, Inoue S
    • Organizer
      IAGG Asia/Oceania Regional Congress 2023
    • Related Report
      2023 Annual Research Report
  • [Presentation] Mitochondrial respiratory chain supercomplex assembly factor COX7RP is transcriptionally regulated by ERα and ERRα and associated with tumor progression in hormone-dependent cancers.2023

    • Author(s)
      Ikeda K, Horie K, Inoue S
    • Organizer
      16th Annual Symposium: Mechanisms and Models of Cancer Meeting, Salk Institute for Biological Studies
    • Related Report
      2023 Annual Research Report
  • [Presentation] Mitochondrial Respiratory Supercomplex and Aging.2023

    • Author(s)
      Inoue S
    • Organizer
      7th NCGG-ICAH-TMIG International Joint Symposium 2023 IAGG-AOR Satellite
    • Related Report
      2023 Annual Research Report
  • [Presentation] [シンポジウム]ミトコンドリア代謝とアンチエイジング2022

    • Author(s)
      井上聡
    • Organizer
      第22回日本抗加齢医学会総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] がん増殖・代謝を制御するミトコンドリア呼吸鎖超複合体の役割2022

    • Author(s)
      池田和博、堀江公仁子、井上聡
    • Organizer
      第8回がんと代謝研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] [シンポジウム]ミトコンドリア呼吸鎖超複合体によるマウス個体レベルでの代謝調節2022

    • Author(s)
      池田和博、堀江公仁子、井上聡
    • Organizer
      第95回日本生化学会大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] [優秀演題賞受賞]筋肉ミトコンドリアの呼吸鎖超複合体形成の可視・定量化に基づくサルコペニア未病への介入・予防法の開発2022

    • Author(s)
      竹岩俊彦、東浩太郎、北見俊守、井上聡
    • Organizer
      第29回日本未病学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ミトコンドリア呼吸鎖超複合体の生細胞FRETイメージングによる定量法の開発と筋疾患治療・予防法への応用2022

    • Author(s)
      竹岩俊彦、東浩太郎、北見俊守、堀江公仁子、池田和博
    • Organizer
      第21回日本ミトコンドリア学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Development of a FRET-based evaluation system of mitochondrial respiratory supercomplex formation in live cells and its potential clinical application to muscle disorders.2022

    • Author(s)
      Takeiwa T, Azuma K, Ikeda K, Horie-Inoue K, Inoue S
    • Organizer
      Keystone Symposia, Mitochondrial Dysfunction: From Ultra-Rare Diseases to Aging, BeaverRunResort, Colorado, United States.
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ミトコンドリア呼吸鎖超複合体を介する代謝リモデリングとがん増殖(ワークショップ発表)2021

    • Author(s)
      池田和博、堀江公仁子、井上聡
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 呼吸鎖超複合体の可視・定量化に基づくミトコンドリア機能促進化合物の同定(ワークショップ発表)2021

    • Author(s)
      東浩太郎、竹岩俊彦、池田和博、井上聡
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 呼吸鎖超複合体イメージング技術の開発による筋肉機能を向上させる新規化合物のハイスループット探索と応用2021

    • Author(s)
      竹岩俊彦、東浩太郎、井上聡
    • Organizer
      第28回日本未病学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ミトコンドリア呼吸鎖超複合体と筋肉、健康長寿(シンポジウム発表)2021

    • Author(s)
      井上聡
    • Organizer
      第8回日本サルコペニア・フレイル学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] COX7RPミトコンドリア呼吸鎖超複合体形成因子を軸とした子宮体がんにおける代謝変容の解明(シンポジウム発表)2021

    • Author(s)
      池田和博、堀江公仁子、井上聡
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 【若手奨励賞・Most Impressive Presentater賞受賞】FRET-based high-throughput screen identifies a compound that promotes mitochondrial function by respiratory chain supercomplex assembly2021

    • Author(s)
      Kobayashi A, Azuma K, Ikeda K, Inoue
    • Organizer
      第44回日本基礎老化学会大会
    • Related Report
      2021 Annual Research Report
  • [Book] ミトコンドリアダイナミクス-機能研究から疾患・老化まで 第2章第3節「ミトコンドリア呼吸と乳がん・子宮がん」2021

    • Author(s)
      池田和博、井上聡
    • Total Pages
      458
    • Publisher
      株式会社エヌ・ティー・エス
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] ミトコンドリア超複合体の形成促進剤、筋力維持又は増進用組成物、及び筋機能低下若しくはミトコンドリア機能低下疾患の治療又は予防用医薬組成物、並びにミトコンドリアの超複合体の形成2022

    • Inventor(s)
      井上聡、東浩太郎、小林天美
    • Industrial Property Rights Holder
      井上聡、東浩太郎、小林天美
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Related Report
      2022 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ミトコンドリア超複合体の形成促進剤、筋力維持又は増進用組成物、及び筋機能低下若しくはミトコンドリア機能低下疾患の治療又は予防用医薬組成物、並びにミトコンドリアの超複合体の形成-以下略2021

    • Inventor(s)
      井上聡、東浩太郎、小林天美
    • Industrial Property Rights Holder
      井上聡、東浩太郎、小林天美
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report

URL: 

Published: 2021-04-28   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi