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Integrated understanding of inner ear disorders and next-generation drug discovery by combination of IoT sensing and iPSC-based medicine

Research Project

Project/Area Number 21H04839
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Research InstitutionKitasato University

Principal Investigator

Fujioka Masato  北里大学, 医学部, 教授 (70398626)

Co-Investigator(Kenkyū-buntansha) 岡野 栄之  慶應義塾大学, 医学部(信濃町), 教授 (60160694)
水足 邦雄  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 病院 耳鼻咽喉科, 講師 (40338140)
岡野 ジェイムス洋尚  東京慈恵会医科大学, 医学部, 教授 (90338020)
小島 博己  東京慈恵会医科大学, 医学部, 教授 (60234762)
細谷 誠  慶應義塾大学, 医学部(信濃町), 講師 (30645445)
栗原 渉  東京慈恵会医科大学, 医学部, 助教 (90826926)
Project Period (FY) 2021-04-05 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000)
Fiscal Year 2023: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2022: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2021: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
KeywordsiPS細胞創薬 / 聴覚障害 / 橋渡し研究 / 霊長類研究 / バイオインフォマティクス / 内耳再生 / 耳科学 / 聴覚医学 / 内耳性難聴 / IoTセンシング / hiPS細胞 / 霊長類モデル
Outline of Research at the Start

霊長類難聴モデルの知見を基盤に、我々は、ヒトiPS細胞創薬とIoTセンシングによる連日自宅検査から得るビッグデータという全く異なる表現形解析を内耳領域で開発し組み合わせ、内耳再生医療とiPS細胞創薬において、世界初の難聴治療薬導出に成功してきた。本研究ではこの研究基盤を用いて、聴覚に関するビッグデータを取得し、難聴の表現形分類に挑戦する。同時に、遺伝学的な網羅的解析データと統合することで、そのエンドタイピングを目指す。ヒトを含む霊長類での内耳性難聴の病態生理の理解に基づく次世代型創薬を実現することにより、治療法不在と言わてきた感音難聴に対する革新的治療法を切れ目なく創出し続けることを目指す。

Outline of Final Research Achievements

We have established a novel method for inducing inner ear cells from human ES/iPS cells to overcome the drawbacks of previous methods. Additionally, we developed a system to monitor physiological activity of differentiated cells via Ca imaging and reported our findings in an international journal. Concurrently, we advanced our research on gene expression and its changes during the embryonic period in the inner ear of the common marmoset, a small non-human primate. We also collected various molecular genetic insights into the differences between Old World and New World monkeys in the inner ear, highlighting the limitations of the marmoset model. Behavioral data on hearing-impaired marmosets were accumulated. Furthermore, we developed a home-based head position fluctuation testing app to examine its physiological significance. From GWAS and informatics, we obtained data suggesting the involvement of inflammaging in age-related hearing loss.

Academic Significance and Societal Importance of the Research Achievements

感音難聴の多くは、音を受容し神経活動へと変換する内耳(蝸牛)の障害で生じる。本邦での有病率は補聴器を要する者で600 万人とされ、65歳以上の30-40%が難聴で生活に支障を来している。難聴はQOL低下のみならず、気分障害や認知症発症のリスク因子でもあり、社会的損失は巨大である。本研究では、霊長類モデルとヒトiPS細胞研究、臨床試験でのIoTセンシングによる症例毎のビッグデータとを統合することで、ヒト内耳性難聴の病態を包括的に理解し、進行性難聴および慢性感音難聴に対する新規治療法を創出し続け、治療標的を鑑別する手法(難聴のエンドタイピング)を樹立することを最終目標に研究を進めた。

Report

(4 results)
  • 2023 Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Comments on the Screening Results   Annual Research Report
  • Research Products

    (60 results)

All 2023 2022 2021 Other

All Journal Article (22 results) (of which Peer Reviewed: 15 results,  Open Access: 11 results) Presentation (33 results) (of which Int'l Joint Research: 7 results,  Invited: 14 results) Remarks (1 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 3 results)

  • [Journal Article] Generation of two induced pluripotent stem cell lines from individuals without auditory disorders2023

    • Author(s)
      Okura Shota、Ishii Honoka、Suzuki Ayano、Saegusa Chika、Fujiki Ko、Sugano Kenshi、Suzuki Noriomi、Saeki Tsubasa、Matsuzaki Saeko、Ozawa Hiroyuki、Fujioka Masato、Hosoya Makoto、Okano Hideyuki
    • Journal Title

      Stem Cell Research

      Volume: 67 Pages: 103017-103017

    • DOI

      10.1016/j.scr.2023.103017

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between genotype and phenotype with special attention to hearing in 14 Japanese cases of NF2-related schwannomatosis2023

    • Author(s)
      Oishi Naoki、Noguchi Masaru、Fujioka Masato、Nara Kiyomitsu、Wasano Koichiro、Mutai Hideki、Kawakita Rie、Tamura Ryota、Karatsu Kosuke、Morimoto Yukina、Toda Masahiro、Ozawa Hiroyuki、Matsunaga Tatsuo
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 6595-6595

    • DOI

      10.1038/s41598-023-33812-w

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Apoptosis of type I spiral ganglion neuron cells in Otof-mutant mice2023

    • Author(s)
      Tsuzuki Nobuyoshi、Namba Kazunori、Saegusa Chika、Mutai Hideki、Nishiyama Takanori、Oishi Naoki、Matsunaga Tatsuo、Fujioka Masato、Ozawa Hiroyuki
    • Journal Title

      Neuroscience Letters

      Volume: 803 Pages: 137178-137178

    • DOI

      10.1016/j.neulet.2023.137178

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potential Usefulness of Tracking Head Movement via a Wearable Device for Equilibrium Function Testing at Home2022

    • Author(s)
      Yamanobe Yoshiharu、Fujioka Masato、Ohashi Masanao、Ozawa Hiroyuki
    • Journal Title

      Journal of Medical Systems

      Volume: 46 Issue: 11 Pages: 80-80

    • DOI

      10.1007/s10916-022-01874-4

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Author Correction: MRI tractography reveals the human olfactory nerve map connecting the olfactory epithelium and olfactory bulb2022

    • Author(s)
      Kurihara Sho、Tei Masayoshi、Hata Junichi、Mori Eri、Fujioka Masato、Matsuwaki Yoshinori、Otori Nobuyoshi、Kojima Hiromi、Okano Hirotaka James
    • Journal Title

      Communications Biology

      Volume: 5 Issue: 1 Pages: 1219-1219

    • DOI

      10.1038/s42003-022-04220-z

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MRI tractography reveals the human olfactory nerve map connecting the olfactory epithelium and olfactory bulb2022

    • Author(s)
      Sho Kurihara, Masayoshi Tei, Junichi Hata, Eri Mori, Masato Fujioka, Yoshinori Matsuwaki, Nobuyoshi Otori, Hiromi Kojima, Hirotaka James Okano
    • Journal Title

      Communications Biology

      Volume: 5 Issue: 1 Pages: 843-843

    • DOI

      10.1038/s42003-022-03794-y

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Critical roles of FGF, RA, and WNT signaling in the development of human otic placode and subsequent lineages in a dish2022

    • Author(s)
      Saeki, T., Yoshimatsu, S., Ishikawa, M., Shin, JW., Hon, C-C., Shibata, S., Hosoya, M., Saegusa, C., Ogawa, K., Fujioka, M., Okano, H.
    • Journal Title

      Regen Ther

      Volume: 20 Pages: 165-186

    • DOI

      10.1016/j.reth.2022.04.008

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Early development of the cochlea of the common marmoset, a non-human primate model2022

    • Author(s)
      Hosoya Makoto、Fujioka Masato、Okahara Junko、Yoshimatsu Sho、Okano Hideyuki、Ozawa Hiroyuki
    • Journal Title

      Neural Development

      Volume: 17 Issue: 1 Pages: 6-6

    • DOI

      10.1186/s13064-022-00162-8

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Otic Organoids Containing Spiral Ganglion Neuron-like Cells Derived from Human-induced Pluripotent Stem Cells as a Model of Drug-induced Neuropathy2022

    • Author(s)
      Kurihara Sho、Fujioka Masato、Hirabayashi Motoki、Yoshida Tomohiko、Hosoya Makoto、Nagase Masashi、Kato Fusao、Ogawa Kaoru、Okano Hideyuki、Kojima Hiromi、Okano Hirotaka James
    • Journal Title

      Stem Cells Translational Medicine

      Volume: 11 Issue: 3 Pages: 282-296

    • DOI

      10.1093/stcltm/szab023

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcanal endoscopic ear surgery for management of ossicular malformation: clinical outcomes of 17 cases2022

    • Author(s)
      Yoshida Alyssa、Hosoya Makoto、Kanzaki Sho、Fujioka Masato、Ozawa Hiroyuki
    • Journal Title

      Acta Oto-Laryngologica

      Volume: 142 Issue: 2 Pages: 154-160

    • DOI

      10.1080/00016489.2022.2039406

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complete Removal of Stage II Congenital Cholesteatoma Destroying Temporomandibular Joints Using Transcanal Endoscopic Ear Surgery With a Mirror Technique: A Case Report2022

    • Author(s)
      Ogawa Shigeki、Hosoya Makoto、Fujioka Masato、Ogawa Kaoru
    • Journal Title

      The Journal of International Advanced Otology

      Volume: 18 Issue: 1 Pages: 88-91

    • DOI

      10.5152/iao.2022.9145

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of conductive olfactory dysfunction using computational fluid dynamics2022

    • Author(s)
      Asama Y, Furutani A, Fujioka M , Ozawa H, Takei S , Shibata S, Ogawa K
    • Journal Title

      PLoS One

      Volume: 17 Issue: 1 Pages: 139-147

    • DOI

      10.1371/journal.pone.0262579

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ヒトiPS細胞由来内耳オルガノイドを用いたシスプラチン障害モデルの解析2022

    • Author(s)
      栗原 渉, 平林 源希, 藤岡 正人, 細谷 誠, 小島 博己
    • Journal Title

      日本耳鼻咽喉科頭頸部外科学会会報

      Volume: 125 Pages: 730-730

    • Related Report
      2022 Annual Research Report
  • [Journal Article] 同一家族の同胞間におけるGJB2変異難聴の聴力レベル差について2022

    • Author(s)
      藤岡 正人, 細谷 誠, 奈良 利光, 守本 倫子, 阪本 浩一, 大津 雅秀, 仲野 敦子, 有本 友季子, 増田 佐和子, 杉内 智子, 益田 慎, 森田 訓子, 小川 郁, 加我 君孝, 松永 達雄
    • Journal Title

      日本耳鼻咽喉科頭頸部外科学会会報

      Volume: 125 Pages: 1037-1038

    • Related Report
      2022 Annual Research Report
  • [Journal Article] 小型霊長類コモンマーモセットを用いた聴覚研究2022

    • Author(s)
      栗原渉、岡野ジェイムス洋尚、藤岡正人
    • Journal Title

      BIO Clinica

      Volume: 37-2 Pages: 91-93

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Dynamic Spatiotemporal Expression Changes in Connexins of the Developing Primate’s Cochlea2021

    • Author(s)
      Hosoya Makoto、Fujioka Masato、Murayama Ayako Y.、Ogawa Kaoru、Okano Hideyuki、Ozawa Hiroyuki
    • Journal Title

      Genes

      Volume: 12 Issue: 7 Pages: 1082-1082

    • DOI

      10.3390/genes12071082

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuronal development in the cochlea of a nonhuman primate model, the common marmoset2021

    • Author(s)
      Hosoya Makoto、Fujioka Masato、Murayama Ayako Y、Ozawa Hiroyuki、Okano Hideyuki、Ogawa Kaoru
    • Journal Title

      Developmental Neurobiology

      Volume: 81 Issue: 8 Pages: 905-938

    • DOI

      10.1002/dneu.22850

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigation of the hearing levels of siblings affected by a single GJB2 variant: Possibility of genetic modifiers2021

    • Author(s)
      Hosoya Makoto、Fujioka Masato、Nara Kiyomitsu、Morimoto Noriko、Masuda Sawako、Sugiuchi Tomoko、Katsunuma Sayaka、Takagi Akira、Morita Noriko、Ogawa Kaoru、Kaga Kimitaka、Matsunaga Tatsuo
    • Journal Title

      International Journal of Pediatric Otorhinolaryngology

      Volume: 149 Pages: 110840-110840

    • DOI

      10.1016/j.ijporl.2021.110840

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] あたらしい創薬のかたち作り:疾患動物モデルを用いない非臨床POC研究(iPS細胞創薬)(テーマ:Pendred症候群の治療)2021

    • Author(s)
      藤岡正人、西山結美、秋山琢己
    • Journal Title

      Otology Japan

      Volume: 31-4 Pages: 425-434

    • Related Report
      2021 Annual Research Report
  • [Journal Article] iPS細胞創薬の実際 Pendred症候群に対するシロリムス少量療法2021

    • Author(s)
      藤岡 正人, 細谷 誠
    • Journal Title

      日本耳鼻咽喉科頭頸部外科学会会報

      Volume: 124-10 Pages: 1331-1340

    • NAID

      130008110553

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 【耳鳴・難聴への効果的アプローチ】感音難聴治療の近未来2021

    • Author(s)
      藤岡 正人, 山野邉 義晴, 細谷 誠
    • Journal Title

      ENTONI

      Volume: 258 Pages: 63-68

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 未来からの提言―Medical Frontline2021

    • Author(s)
      藤岡正人
    • Journal Title

      月刊 JMS(ジャパン・メディカル・ソサエティ)

      Volume: 4月号

    • Related Report
      2021 Annual Research Report
  • [Presentation] 内耳領域におけるiPS細胞技術を用いたモデル研究と創薬2023

    • Author(s)
      藤岡 正人
    • Organizer
      第22回日本再生医療学会総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 内耳領域における iPS 細胞技術を用いたモデル研究と創薬 iPSC-based drug discovery and development for the hearing disorder2022

    • Author(s)
      藤岡 正人
    • Organizer
      第22回日本再生医療学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] “聴こえ”にまつわる耳寄りな話:難聴の原因・予防から最新の治療まで2022

    • Author(s)
      藤岡 正人
    • Organizer
      東京三田倶楽部例会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 内耳障害に対するiPS細胞創薬:Pendred症候群に対するシロリムス療法の第I/II相医師主導治験(PENDLRA試験)2022

    • Author(s)
      藤岡 正人
    • Organizer
      日本再生医療学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] DRUG DISCOVERY AND DEVELOPMENT FOR THE HEARING LOSS USING PATIENT-DERIVED IPSCS: A PHASE I/IIA CLINICAL TRIAL FOR PENDRED SYNDROME/DFNB42022

    • Author(s)
      Masato Fujioka
    • Organizer
      7th East Asian Symposium on Otology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Drug Discovery and Development of Inner Ear Disorders with hiPSCs: A Phase I/IIa Double-Blind Study of Low dose Sirolimus Therapy for Pendred Syndrome2022

    • Author(s)
      Masato Fujioka
    • Organizer
      2022 Team Science Award Symposium
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Primate models and Remote clinical trials: Strategy and Tactics for minding species gaps in between rodents and human2022

    • Author(s)
      Masato Fujioka
    • Organizer
      2nd. Inner Ear Therapeutics Summit
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of interregional connectivity using MRI images of a common marmoset model of hearing loss2022

    • Author(s)
      Motoki Hirabayashi,Sho Kurihara, Junichi Hata,Daisuke Yoshimaru,Masato Fujioka,Yutaka Yamamoto, Hiromi Kojimi,Hirotaka James
    • Organizer
      Neuro2022-日本神経科学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Pythonを用いた眼振運動追跡プログラムの検討2022

    • Author(s)
      権 英祥、山野邉 義晴、藤岡 正人
    • Organizer
      耳鼻臨,広島
    • Related Report
      2022 Annual Research Report
  • [Presentation] 幹細胞技術を用いた内耳性難聴に対する治療法の開発2022

    • Author(s)
      藤岡 正人
    • Organizer
      成育医療センターセミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 幹細胞医学を用いた感音難聴の治療薬創出:iPS細胞創薬から内耳再生まで2022

    • Author(s)
      藤岡 正人
    • Organizer
      神奈川地方部会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 内耳血管条辺縁細胞の製造方法, 薬剤の評価方法, 及び薬剤評価用細胞培養物2022

    • Author(s)
      藤岡正人, 三枝智香
    • Organizer
      BioJapan, 横浜
    • Related Report
      2022 Annual Research Report
  • [Presentation] “加齢性難聴”のマルチモーダル研究2022

    • Author(s)
      藤岡 正人
    • Organizer
      第32回日本耳科学会総会・学術講演会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 小型霊長類難聴モデルと超高磁場MRIで明らかにする難聴が及ぼす脳の変化 common marmosetのVBM・VBA解析2022

    • Author(s)
      平林 源希, 栗原 渉, 新村 一, 吉村 豪兼, 細谷 誠, 藤岡 正人
    • Organizer
      第32回日本耳科学会総会・学術講演会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 小型霊長類を用いた音響外傷性難聴モデルの作製とその行動科学的解析2022

    • Author(s)
      栗原 渉, 平林 源希, 新村 一, 藤岡 正人, 細谷 誠, 山本 裕, 小島 博己
    • Organizer
      第32回日本耳科学会総会・学術講演会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Otof遺伝子変異マウスにおけるらせん神経節細胞のアポトーシス2022

    • Author(s)
      都築 伸佳, 難波 一徳, 藤岡 正人, 三枝 智香, 細谷 誠, 西山 崇経, 松永 達雄, 小澤 宏之
    • Organizer
      第32回日本耳科学会総会・学術講演会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] ウェアラブルデバイスによる頭部動揺検査による自宅平衡機能検査の可能性2022

    • Author(s)
      山野邉義晴,藤岡正人
    • Organizer
      第81回めまい平衡医学会総会・学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Cutting edge of the development of drugs for the deafness in 2022: What is the clinically meaningful improvement?2022

    • Author(s)
      Masato Fujioka
    • Organizer
      the 4th World Congress on Endoscopic Ear Surgery Innovations in Ear Surgery and Hearing Therapeutics
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Let’s start with 3 hand (double handed) TEES!!: How to set-up, learn and educate2022

    • Author(s)
      Masato Fujioka
    • Organizer
      the 4th World Congress on Endoscopic Ear Surgery Innovations in Ear Surgery and Hearing Therapeutics
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] “聴こえ”にまつわる耳寄りな話:難聴の原因・予防から最新の治療まで2022

    • Author(s)
      藤岡 正人
    • Organizer
      東京三田倶楽部, 東京
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] PTCH1-null induced pluripotent stem cells exclusively differentiate into immature ectodermal cells with large areas of medulloblastoma-like tissue2022

    • Author(s)
      長尾和右、三枝知香、高山吉永、亀山孝三、藤岡正人
    • Organizer
      第45回日本分子生物学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 内耳障害に対するiPS細胞創薬:Pendred症候群に対するシロリムス療法の第I/II相医師主 導治験(PENDLRA試験) iPSC-based drug discovery and development for hearing and balance disorder2022

    • Author(s)
      藤岡正人
    • Organizer
      第21回日本再生医療学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] コモンマーモセットの難聴モデルにおける脳Voxel Based Analysisおよび行動解析2021

    • Author(s)
      平林 源希, 栗原 渉, 野武 幸子, 力武 聖月, 藤岡 正人, 山本 裕, 小島 博己
    • Organizer
      第66回日本聴覚医学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 耳科学におけるベンチャー企業の動向 日本初の耳科関連ベンチャー企業「株式会社オトリンク(Otolink Inc.)」2021

    • Author(s)
      小川 郁, 新田 清一, 藤岡 正人, 細谷 誠, 松崎 佐栄子
    • Organizer
      第31回日本耳科学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 一過性にFT3高値を呈したPendred症候群の一例2021

    • Author(s)
      高橋 利奈, 栗原 勲, 小林 佐紀子, 宮下 和季, 横田 健一, 杉田 絵里那, 日鼻 瑛, 藤岡 正人, 伊藤 裕
    • Organizer
      第64回日本甲状腺学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 慶應義塾大学臨床遺伝学センター難聴遺伝外来の動向<BR>―難聴における臨床遺伝学2021

    • Author(s)
      山野邉義晴、藤岡正人、吉浜圭介、細谷誠、小川郁、松永達雄
    • Organizer
      第122回日本耳鼻咽喉科学会総会・学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Clinical audiology in our facility for the hereditary hearing loss: From clinics to basic research and backwards当院の難聴遺伝外来における基礎・臨床一体型研究2021

    • Author(s)
      藤岡 正人、山野邉 義晴、吉浜 圭祐、 細谷 誠、三枝 智香、小澤 宏之、小崎 健次郎、松永 達雄
    • Organizer
      日本人類遺伝学会第66回大会 第28回日本遺伝子診療学会大会 合同開催
    • Related Report
      2021 Annual Research Report
  • [Presentation] Pendred症候群/DFNB4に対する、オートファジー促進を作用機序としたシロリムス少量療法の単施設二重盲検並行群間比較第I/IIa相医師主導治験(PENDLRA試験)2021

    • Author(s)
      藤岡 正人、細谷 誠、山野邉 義晴
    • Organizer
      第2回シロリムス新作用研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 低用量シロリムス療法における有害事象:Pendred症候群/DFNB4を対象に2021

    • Author(s)
      山野邉義晴、藤岡正人、西山結美
    • Organizer
      第2回シロリムス新作用研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ヒト多能性幹細胞からの血管条辺縁細胞分化誘導系の検討2021

    • Author(s)
      三枝智香、細谷誠、藤岡正人、小澤宏之
    • Organizer
      第31回日本耳科学会総会・学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] INDUCED MARGINAL CELLS OF INNER EAR FROM HUMAN IPS CELLS AS THE DISEASE MODELS FOR HEARING LOSS2021

    • Author(s)
      Chika Saegusa、Hiroyuki Ozawa、Hideyuki Okano、Masato Fujioka
    • Organizer
      ISSCR/JSRM 2021 Tokyo International Symposium
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DRUG DISCOVERY AND DEVELOPMENT FOR THE HEARING LOSS USING PATIENT-DERIVED IPSCS: A PHASE I/IIA CLINICAL TRIAL FOR PENDRED SYNDROME/DFNB42021

    • Author(s)
      Masato Fujioka
    • Organizer
      ISSCR/JSRM 2021 Tokyo International Symposium
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] iPS細胞創薬の実際: Pendred症候群の病態解析とシロリムス少量療法の創出2021

    • Author(s)
      藤岡正人
    • Organizer
      第64回日本甲状腺学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Remarks] 北里大学医学部分子遺伝学 研究内容

    • URL

      https://www.med.kitasato-u.ac.jp/lab/molgen/sub3.html

    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] Methods for Producing Inner Ear Stria Vascularis Marginal Cells, Methods for Evaluating Drugs, and Cell Cultures for Drug Evaluation2022

    • Inventor(s)
      三枝智香, 藤岡正人, 岡野栄之
    • Industrial Property Rights Holder
      三枝智香, 藤岡正人, 岡野栄之
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Related Report
      2022 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 内耳前駆細胞の製造方法、内耳有毛細胞の製造方法、薬剤の評価方法、及び内耳細胞分化 誘導用組成物2021

    • Inventor(s)
      佐伯 翼、藤岡 正 人、細谷 誠、岡野 栄之、松崎 佐栄子
    • Industrial Property Rights Holder
      学校法人慶應義塾
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 内耳有毛細胞の製造方法、薬剤の評価方法、及び細胞分化誘導用組成物2021

    • Inventor(s)
      佐伯 翼、藤岡 正 人、細谷 誠、岡野 栄之、松崎 佐栄子
    • Industrial Property Rights Holder
      学校法人慶應義塾
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 内耳血管条辺縁細胞の製造方法、薬剤の評価方法、及び薬剤評価用細胞培養物2021

    • Inventor(s)
      三枝智香、藤岡正人、岡野栄之
    • Industrial Property Rights Holder
      学校法人慶應義塾
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-098423
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report

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Published: 2021-04-28   Modified: 2025-01-30  

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