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Adaptive evolution/change in mammals to exogenous chemicals (xenobiotics)

Research Project

Project/Area Number 21H04919
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 63:Environmental analyses and evaluation and related fields
Research InstitutionHokkaido University

Principal Investigator

石塚 真由美  北海道大学, 獣医学研究院, 教授 (50332474)

Co-Investigator(Kenkyū-buntansha) 早川 卓志  北海道大学, 地球環境科学研究院, 助教 (00758493)
武田 一貴  北里大学, 獣医学部, 講師 (00896350)
川合 佑典  帯広畜産大学, 畜産学部, 准教授 (10709546)
山崎 淳平  北海道大学, 獣医学研究院, 准教授 (20732902)
池中 良徳  北海道大学, One Healthリサーチセンター, 教授 (40543509)
中山 翔太  北海道大学, 獣医学研究院, 准教授 (90647629)
Project Period (FY) 2021-04-05 – 2026-03-31
Project Status Granted (Fiscal Year 2025)
Budget Amount *help
¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2025: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2024: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2023: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2022: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2021: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
KeywordsシトクロムP450 / グルクロン酸転移酵素 / 硫酸転移酵素 / 哺乳類 / 環境適応 / グルクロン酸抱合 / 硫酸抱合 / 適応進化 / xenobiotics / 化学物質代謝
Outline of Research at the Start

本研究では食性の観点および重度環境汚染域に棲息する動物を中心に、哺乳類が日常的に曝露される化学物質にどのように適応してきたのか、その進化を機能面から明らかにする。これまでの研究で構築してきた多様な動物試料を用いた研究体制を生かし、食性のユニークな動物種を対象としたウェットな実験や、データベースを用いた網羅的解析により、外来性の化学物質に対する動物の「適応」と「共存」メカニズムを明らかにする。

Outline of Annual Research Achievements

我々はこれまでの研究により、高次の動物が外来性の化学物質(Xenobiotics)への「適応」ために、化学物質の代謝や排泄など、解毒のカスケードに沿って薬物代謝酵素などの一連の多様性を発展させてきたとの仮説を立てた。化学物質感受性には多様性があり、解毒代謝酵素の解析から、この多様性獲得の主要因は食餌由来の化学物質である可能性を報告した。本研究では食性の観点および重度環境汚染域に棲息する動物を中心に、哺乳類が日常的に曝露される化学物質にどのように適応してきたのか、多様な種を用いてその進化を機能面から明らかにする。これまでの研究で構築してきた多様な動物試料を用いた研究体制を生かし、食性のユニークな動物種を対象としたウェットな実験や、データベースを用いた網羅的解析により、外来性の化学物質に対する動物の「適応」と「共存」メカニズムを明らかにすることを目的としている。
本研究では、哺乳類の肝臓における「解毒」で重要なシトクロムP450(特にCYP2、CYP3ファミリー)、グルクロン酸転移酵素、硫酸転移酵素の分子種に特にフォーカスして、関連分子の比較解析を行う計画を立てた。そこで、今年度は、国内の動物園に限らず、海外の国立公園より、特徴ある食性の動物種の肝臓を収集した。ナミビア、ザンビアの国立公園からゾウの試料を採集したほか、in silico解析により、ゾウのP450の特徴を明らかにした。特に、一部のCYP2サブファミリー欠損していることなどを報告した。2022年度の研究に加えて、2023年度では草食動物、とくにアフリカ獣上目に着目した解析を実施することができた。
また、解毒に重要な腸内細菌についても解析を実施することができた。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

2023年度にも研究成果を学術雑誌報告し、多くの学会発表を行ったことから、研究がおおむね順調に進んでいると評価した。

Strategy for Future Research Activity

現在、順調に研究を進めている。今後、さらにシトクロムP450やグルクロン酸転移酵素以外の解毒酵素にも着目する。また食性に加えて、アフリカ獣条目など、特異的な遺伝体系を持つ動物種にも解析を進める。

Report

(4 results)
  • 2023 Annual Research Report
  • 2022 Annual Research Report
  • 2021 Comments on the Screening Results   Annual Research Report
  • Research Products

    (48 results)

All 2024 2023 2022 2021 Other

All Int'l Joint Research (5 results) Journal Article (17 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 16 results,  Open Access: 10 results) Presentation (26 results) (of which Int'l Joint Research: 11 results,  Invited: 4 results)

  • [Int'l Joint Research] ザンビア大学(ザンビア)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] ナミビア大学(ナミビア)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] カセサート大学(タイ)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] ザンビア大学(ザンビア)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] ノースウェスト大学(南アフリカ)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Pesticide Contamination Levels in the Stomach Contents of Wild Raccoons (Procyon lotor) and Masked Palm Civets (Paguma larvata) in Japan.2024

    • Author(s)
      So Shinya, Mariko Sashika, Miku Minamikawa, Tetsuji Itoh, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Shouta M. M. Nakayama, Mayumi Ishizuka, Yoshinori Ikenaka.
    • Journal Title

      Environmental Toxicology and Chemistry.

      Volume: 349 Issue: 5 Pages: 123907-123907

    • DOI

      10.1002/etc.5828

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of anticoagulant rodenticide sensitivity by examining in vivo and in vitro responses in avian species, focusing on raptors.2024

    • Author(s)
      K Khidkhan, F Yasuhira, A Saengtienchai, C Kasorndorkbua, R Sitdhibutr, Kohei Ogasawara, H Adachi, YWatanabe, K Saito, Hidefumi Sakai, Kazuo Horikoshi, Hajime Suzuki, Yusuke K. Kawai, Kazuki Takeda, Yared B. Yohannes, Y Ikenaka, BA Rattner, M Ishizuka, SMM Nakayama
    • Journal Title

      Environmental Pollution.

      Volume: 341 Pages: 122837-122837

    • DOI

      10.1016/j.envpol.2023.122837

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surveys of eleven species of wild and zoo birds and feeding experiments in white-tailed eagles reveal differences in the composition of the avian gut microbiome based on dietary habits between and within species2023

    • Author(s)
      Kohei Ogasawara, Naoki Yamada, Shouta MM Nakayama, Yukiko Watanabe, Keisuke Saito, Akane Chiba, Yoshitake Uchida, Kaoru Ueda, Yasunori Takenaka, Kentaro Kazama, Mami Kazama, Junya Yamagishi, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 85 Issue: 12 Pages: 1355-1365

    • DOI

      10.1292/jvms.23-0138

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of the Effect of Pb Pollution on Avian Influenza Virus-Specific Antibody Production in Black-Headed Gulls (Chroicocephalus ridibundus)2023

    • Author(s)
      Nana Ushine, Makoto Ozawa, Shouta M. M. Nakayama, Mayumi Ishizuka, Takuya Kato, Shin-ichi Hayama
    • Journal Title

      Animals

      Volume: 13 Issue: 14 Pages: 2338-2338

    • DOI

      10.3390/ani13142338

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Comparative Genomic and Phylogenetic Investigation of the Xenobiotic Metabolism Enzymes of Cytochrome P450 in Elephants Shows Loss in CYP2E and CYP4A.2023

    • Author(s)
      Kanami Watanabe, Mitsuki Kondo, Yoshinori Ikenaka, Shouta M. M. Nakayama, Mayumi Ishizuka.
    • Journal Title

      Animals

      Volume: 13 Issue: 12 Pages: 1939-1939

    • DOI

      10.3390/ani13121939

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characteristics of cytochrome P450-dependent metabolism against acetamiprid in the musk shrew (Suncus murinus)2023

    • Author(s)
      Shinya So、Kawai Yusuke、Kondo Mitsuki、Nakayama Shouta M.M.、Ishizuka Mayumi、Ikenaka Yoshinori
    • Journal Title

      Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology

      Volume: 265 Pages: 109537-109537

    • DOI

      10.1016/j.cbpc.2022.109537

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of cytochrome P450-dependent metabolism in the liver of the wild raccoon, <i>Procyon lotor</i>2022

    • Author(s)
      SHINYA So、YOHANNES Yared Beyene、IKENAKA Yoshinori、NAKAYAMA Shouta MM、ISHIZUKA Mayumi、FUJITA Shoichi
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 84 Issue: 12 Pages: 1665-1672

    • DOI

      10.1292/jvms.22-0182

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Duplication, Loss, and Evolutionary Features of Specific UDP-Glucuronosyltransferase Genes in Carnivora (Mammalia, Laurasiatheria)2022

    • Author(s)
      Kondo Mitsuki、Ikenaka Yoshinori、Nakayama Shouta M. M.、Kawai Yusuke K.、Ishizuka Mayumi
    • Journal Title

      Animals

      Volume: 12 Issue: 21 Pages: 2954-2954

    • DOI

      10.3390/ani12212954

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Specific Gene Duplication and Loss of Cytochrome P450 in Families 1-3 in Carnivora (Mammalia, Laurasiatheria)2022

    • Author(s)
      Kondo Mitsuki、Ikenaka Yoshinori、Nakayama Shouta M. M.、Kawai Yusuke K.、Ishizuka Mayumi
    • Journal Title

      Animals

      Volume: 12 Issue: 20 Pages: 2821-2821

    • DOI

      10.3390/ani12202821

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Estimation of the reference lead (Pb) concentration levels affecting immune cells in the blood of Black-headed Gulls (Chroicocephalus ridibundus, Laridae)2022

    • Author(s)
      Ushine Nana、Kurata Osamu、Tanaka Yoshikazu、Nakayama Shouta M.M、Ishizuka Mayumi、Kato Takuya、Hayama Shin-Ichi
    • Journal Title

      Avian Conservation and Ecology

      Volume: 17 Issue: 2

    • DOI

      10.5751/ace-02336-170240

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Toxicokinetic analysis of the anticoagulant rodenticides warfarin & diphacinone in Egyptian fruit bats (Rousettus aegyptiacus) as a comparative sensitivity assessment for Bonin fruit bats (Pteropus pselaphon)2022

    • Author(s)
      Takeda Kazuki、Manago Kosuke、Morita Ayuko、Kawai Yusuke K.、Yasuo Nobuaki、Sekijima Masakazu、Ikenaka Yoshinori、Hashimoto Takuma、Minato Ryuichi、Oyamada Yusuke、Horikoshi Kazuo、Suzuki Hajime、Ishizuka Mayumi、Nakayama Shouta M.M.
    • Journal Title

      Ecotoxicology and Environmental Safety

      Volume: 243 Pages: 113971-113971

    • DOI

      10.1016/j.ecoenv.2022.113971

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of the Effects of Neonicotinoid Insecticides on Wild Raccoon, Procyon lotor in Hokkaido, Japan: Urinary Concentrations and Hepatic Metabolic Capability of Neonicotinoids2022

    • Author(s)
      Shinya So、Sashika Mariko、Minamikawa Miku、Itoh Tetsuji、Yohannes Yared Beyene、Nakayama Shouta M. M.、Ishizuka Mayumi、Nimako Collins、Ikenaka Yoshinori
    • Journal Title

      Environmental Toxicology and Chemistry

      Volume: 41 Issue: 8 Pages: 1865-1874

    • DOI

      10.1002/etc.5349

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolomic Alteration in the Plasma of Wild Rodents Environmentally Exposed to Lead: A Preliminary Study2022

    • Author(s)
      Nakata Hokuto、Eguchi Akifumi、Nakayama Shouta M. M.、Yabe John、Muzandu Kaampwe、Ikenaka Yoshinori、Mori Chisato、Ishizuka Mayumi
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 19 Issue: 1 Pages: 541-541

    • DOI

      10.3390/ijerph19010541

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glutathione S-transferase gene polymorphisms in association with susceptibility to lead toxicity in lead- and cadmium-exposed children near an abandoned lead-zinc mining area in Kabwe, Zambia2021

    • Author(s)
      Yohannes Yared Beyene、Nakayama Shouta M. M.、Yabe John、Toyomaki Haruya、Kataba Andrew、Nakata Hokuto、Muzandu Kaampwe、Ikenaka Yoshinori、Choongo Kennedy、Ishizuka Mayumi
    • Journal Title

      Environmental Science and Pollution Research

      Volume: 29 Issue: 5 Pages: 6622-6632

    • DOI

      10.1007/s11356-021-16098-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Simultaneous quantification of imidacloprid and its metabolites in tissues of mice upon chronic low-dose administration of imidacloprid2021

    • Author(s)
      Nimako Collins、Ikenaka Yoshinori、Akoto Osei、Fujioka Kazutoshi、Taira Kumiko、Arizono Koji、Kato Keisuke、Takahashi Keisuke、Nakayama Shouta M.M.、Ichise Takahiro、Ishizuka Mayumi
    • Journal Title

      Journal of Chromatography A

      Volume: 1652 Pages: 462350-462350

    • DOI

      10.1016/j.chroma.2021.462350

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genome-wide DNA methylation analysis of dogs with high lead exposure living near a lead mining area in Kabwe, Zambia2021

    • Author(s)
      Yamazaki Jumpei、Toyomaki Haruya、Nakayama Shouta M.M.、Yabe John、Muzandu Kaampwe、Jelinek Jaroslav、Yokoyama Shoko、Ikenaka Yoshinori、Takiguchi Mitsuyoshi、Ishizuka Mayumi
    • Journal Title

      Environmental Pollution

      Volume: 286 Pages: 117229-117229

    • DOI

      10.1016/j.envpol.2021.117229

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evolutionary history of mammalian UDP-glucuronosyltransferase (UGT)1 and UGT2 families: the emergence of UGT2B subfamily in eutherians after the diversification of flowering plants2021

    • Author(s)
      View ORCID ProfileYusuke K. Kawai, Kasumi Sano, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mitsuki Kondo, Akira Kubota, Mayumi Ishizuka
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2021.08.20.457063

    • Related Report
      2021 Annual Research Report
    • Open Access
  • [Presentation] 日本の野生猛禽類及びガン・カモ類における鉛汚染の実態と鉛同位体比を用いた曝露源の解明2023

    • Author(s)
      丸山瑞貴、銅谷理緒、牛根奈々、小笠原浩平、渡辺有希子、齊藤慶輔、栗谷豪、中川光弘、池中良徳、石塚真由美、中山翔太
    • Organizer
      第2回環境化学物質3学会合同大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] アジアゾウとアフリカゾウにおけるエタノール及びアシクロビルの代謝能-アルコール脱水素酵素の遺伝学的比較解析からの考察2023

    • Author(s)
      森田鮎子,近藤充希,渡邉可菜実,池中良徳,中山翔太,石塚真由美
    • Organizer
      第29回日本野生動物医学会大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 穀物食性と魚食性鳥類が持つ腸内細菌叢の解析2023

    • Author(s)
      小笠原浩平、山田尚輝、千葉茜、内田義崇、境秀文、竹中康進、風間健太郎、風間真美、山岸潤也、池中良徳、中山翔太、石塚真由美
    • Organizer
      第29回日本野生動物医学会大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Evaluation of anticoagulant rodenticides (ARs) sensitivity of warfarin and diphacinone in sea turtle2023

    • Author(s)
      Shouta MM Nakayama, Yoshiya Yamamura, Satomi Kondo, Yoshinori Ikenaka, Mayumi Ishizuka
    • Organizer
      ICCP450
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evolution of phase II xenobiotic metabolism enzymes in mammalians.2023

    • Author(s)
      Mitsuki Kondo, Kanami Watanabe, Yoshinori Ikenaka, Shouta M. M. Nakayama, Mayumi Ishizuka
    • Organizer
      ICCP450
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Could alcohol make elephants drunk or not? insight from a comparative genetic analysis of alcohol dehydrogenase.2023

    • Author(s)
      Ayuko Morita, Mitsuki Kondo, Kanami Watanabe, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka.
    • Organizer
      International Symposium- Impact of Chemical and Biological Hazards on the Environment, Animals and Human Health and its Countermeasure
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Simultaneous analysis of heavy metal and pesticides in feces of wild African savanna elephants in Lower Zambezi National Park, Zambia.2023

    • Author(s)
      Kanami Watanabe, Nelly Banda, Yared B. Yohannes, Rio Doya, John Yabe, Kaampwe Muzandu, Andrew Kataba, Yoshinori Ikenaka, Shouta, M.M. Nakayama, Mayumi Ishizuka
    • Organizer
      The 19th International Elephant Conservation and Research Symposium
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A comparative genetic analysis of alcohol dehydrogenase in Asian and African elephants: insight into ethanol and acyclovir metabolism.2023

    • Author(s)
      Ayuko Morita, Mitsuki Kondo, Kanami Watanabe, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka.
    • Organizer
      The 19th International Elephant Conservation and Research Symposium
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of anticoagulant rodenticides (ARs) effects in sea turtles by metabolome and lipidome analysis.2023

    • Author(s)
      Shouta MM Nakayama, Yoshiya Yamamura, Satomi Kondo, Akifumi Eguchi, Yoshinori Ikenaka, Mayumi Ishizuka.
    • Organizer
      SETAC North America 44th Annual Meeting.
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ザンビア・カブエ地区における高濃度鉛汚染を示した犬のゲノムワイドなDNAメチル化解析2022

    • Author(s)
      山﨑 淳平、豊巻 治也、中山 翔太、Yabe John、Muzandu Kaampwe、Jelinek Jaroslav、横山 晶子、池中 良徳、滝口 満喜、石塚 真由美
    • Organizer
      Japan Geoscience Union (JpGU) Meeting
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 小笠原諸島固有種における抗凝固系殺鼠剤に対する感受性試験2022

    • Author(s)
      小出将士,安平芙由,一瀬貴大,小田谷嘉弥,鈴木創,堀越和夫,池中良徳,石塚真由美,中山翔太
    • Organizer
      環境化学物質3学会合同大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 鳥類シナントロープ(ヒト生活圏近傍動物種)におけるPOPs蓄積と代謝特性の解明2022

    • Author(s)
      水川葉月、渡辺桃加、一瀬貴大、石塚真由美、池中良徳、中山翔太、高橋真
    • Organizer
      環境化学物質3学会合同大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Wild Lizards as a Target of Heavy Metal Biomonitoring Focusing on Land Use Patterns; Example from a Former Mining Site in Zambia2022

    • Author(s)
      Rio Doya, Shouta M.M. Nakayama, Hokuto Nakata, Mitsuki Kondo, Golden Zyambo, John Yabe, Kaampwe Muzandu, Yoshinori Ikenaka, and Mayumi Ishizuka
    • Organizer
      第49回日本毒性学会学術年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Carnivora (Mammalia, Laurasiatheria) specific evolutional features and specific gene loss and duplication and in CYP450 1-3 families2022

    • Author(s)
      近藤充希、池中良徳、中山翔太、川合 佑典、石塚真由美
    • Organizer
      第49回日本毒性学会学術年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 水圏から見る抗凝血殺鼠剤散布~ウミガメにおける毒性評価の試み~2022

    • Author(s)
      山村快哉、近藤理美、北山知代、武田一貴一瀬貴大、池中良徳、石塚真由美、中山翔太
    • Organizer
      第49回日本毒性学会学術年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ステロイドホルモンおよびその抱合体化物の血中組成における動物種差2022

    • Author(s)
      伊藤愛真、近藤充希、池中良徳、田中亜紀、下鶴倫人、佐鹿万里子、柳川洋二郎、笠松雅彦、角川雅俊、中山翔太、石塚真由美
    • Organizer
      第165回日本獣医学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Sensitivity and toxicity evaluation of anticoagulant rodenticides, warfarin and diphacinone in green sea turtles (Chelonia mydas).2022

    • Author(s)
      Shouta MM Nakayama, Yoshiya Yamamura, Satomi Kondo, Chiyo Kitayama, Takahiro Ichise, Yoshinori Ikenaka, Mayumi Ishizuka
    • Organizer
      15th International Conference of Asian Society of Conservation Medicine
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Simultaneous quantitative analysis of pesticides on wild raccoons (Procyon lotor) in Japan.2022

    • Author(s)
      So Shinya, Mariko Sashika, Miku Minamikawa, Shouta MM Nakayama, Mayumi Ishizuka, Yoshinori Ikenaka
    • Organizer
      15th International Conference of Asian Society of Conservation Medicine
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phylogenetic analysis of Elephant Cytochrome P450 (CYP) gene family.2022

    • Author(s)
      Kanami Watanabe, Mitsuki Kondo, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka
    • Organizer
      15th International Conference of Asian Society of Conservation Medicine
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Avian interspecific differences in VKOR activity and inhibition: Insights from amino acid sequence and mRNA expression ratio of VKORC1 and VKORC1L1.2022

    • Author(s)
      Ayuko Morita, Shouta M.M. Nakayama, Yoshinori Ikenaka, Yusuke K. Kawai, Yared B. Yohannes, Kohei Ogasawara, Yukiko Watanabe, Keisuke Saito, Kaoru Ueda, Mayumi Ishizuka
    • Organizer
      15th International Conference of Asian Society of Conservation Medicine
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of anticoagulant rodenticides, warfarin and diphacinone sensitivity in sea turtles2022

    • Author(s)
      Shouta M.M. Nakayama, Yoshiya Yamamura, Satomi Kondo, Chiyo Kitayama, Takahiro Ichise, Yoshinori Ikenaka, Mayumi Ishizuka.
    • Organizer
      SETAC North America 43rd Annual Meeting
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 食肉目Cytochrome P450 1-3 ファミリーの遺伝子重複・欠損による進化性状解明2022

    • Author(s)
      近藤充希、池中良徳、中山翔太、川合佑典、石塚真由美
    • Organizer
      内外環境応答・代謝酵素研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] (Epi) Genetic Effects of δ-Aminolevulinic Acid Dehydratase (ALAD) in Children Exposed to Environmental Lead; a primary study from Kabwe, Zambia.2021

    • Author(s)
      Yared Beyene Yohannes, Shouta M.M. Nakayama, John Yabe, Hokuto Nakata, Haruya Toyomaki, Andrew Kataba, Kaampwe Muzandu, Kennedy Choongo, Yoshinori Ikenaka, Mayumi Ishizuka.
    • Organizer
      日本毒性学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Simultaneous Quantification of Imidacloprid and its Metabolites in Tissues of Mice upon Chronic Low-dose Administration of Imidacloprid.2021

    • Author(s)
      Collins Nimako, Yoshinori Ikenaka, Osei Akoto, Kazutoshi Fujioka, Kumiko Taira, Koji Arizono, Keisuke Kato, Keisuke Takahashi, Shouta M.M. Nakayama, Takahiro Ichise and Mayumi Ishizuka.
    • Organizer
      日本毒性学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] xenobiotics 代謝と解毒の動物種差2021

    • Author(s)
      石塚真由美, 中山翔太, 池中良徳
    • Organizer
      日本毒性学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 薬物 /異物代謝と毒性の種差2021

    • Author(s)
      石塚真由美、池中良徳、中山翔太
    • Organizer
      日本薬物動態学会
    • Related Report
      2021 Annual Research Report
    • Invited

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Published: 2021-04-28   Modified: 2025-06-20  

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