• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Next-generation mechanomedicine through the development of new mechanical load devices

Research Project

Project/Area Number 21H04960
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionOkayama University

Principal Investigator

Naruse Keiji  岡山大学, 医歯薬学域, 教授 (40252233)

Co-Investigator(Kenkyū-buntansha) 西山 雅祥  近畿大学, 理工学部, 准教授 (10346075)
高橋 賢  岡山大学, 医歯薬学域, 准教授 (50432258)
片野坂 友紀  金城学院大学, 薬学部, 准教授 (60432639)
森松 賢順  岡山大学, 医歯薬学域, 助教 (70580934)
入部 玄太郎  旭川医科大学, 医学部, 教授 (90284885)
Project Period (FY) 2021-04-05 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
Fiscal Year 2023: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2022: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2021: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Keywordsメカニカルストレス / 高圧力環境 / 圧力刺激 / 伸展刺激 / 剪断応力 / 細胞内カルシウムイオン / 活性酸素種
Outline of Research at the Start

生体各所で、メカニカルストレス応答不全が疾患発症に直結することが実証され、疾患の成因解明・治療にメカニカルストレスを考慮に入れたメカノメディスンを我々が提唱してきた.開発した伸展や剪断応力を負荷する装置は、現在までに汎用的な技術として確立されてきたが、生体組織でのメカニカルストレスはより複雑であるため、解明したい生命現象に沿ったメカニカルストレス負荷装置の開発が急務であった.そこで本研究では、より複雑な生体環境を模倣するメカニカルストレス刺激装置を開発する.さらにこれを用いて、これまで不明であった分野へメカノメディスン研究を発展させ、生体のメカニカルストレス応答やこれに基づいた治療へ貢献する.

Outline of Final Research Achievements

In this study, we developed a novel stretch and hydrostatic pressure loading device that enables real-time observation of cellular morphological changes and intracellular signaling mechanisms under high pressure, as well as gene expression analysis. Using this device, we applied high pressure to chondrocytes and cardiomyocytes to elucidate their intracellular responses to pressure stimuli. For the heart, we investigated the role of the TRPV2 channel during the developmental stages from the fetal period and the role of reactive oxygen species in cardiac contractility. Additionally, we developed a human heart-on-a-chip by co-culturing vascular endothelial cells, fibroblasts, and iPS-derived cardiomyocytes on a microfluidic chip, enabling the simulation of human heart responses to blood pressure and flow.

Academic Significance and Societal Importance of the Research Achievements

本研究は、歯周組織や関節軟骨などの組織において生理的に生じる強い圧力を負荷しつつ、細胞の応答をリアルタイムで観察するシステムを確立した点で、医学・生物学の新しい領域を切り拓いたといえる。今後は、歯軋り・食いしばりなどにより生じる過大な圧力が歯周組織に与える影響に関し、病態生理学的な解析が可能となろう。また心臓に関しては、胎児期からの成長の過程や、血圧に対する収縮応答の仕組みが明らかとなった。これを発展させることにより、糖尿病が心不全を誘発する仕組みの解明などの応用が期待できる。さらにマルチメカニカルストレスの負荷が可能なヒト心臓チップの開発は、ヒトの心臓を対象とした研究に道を開いたといえよう。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Comments on the Screening Results   Annual Research Report
  • Research Products

    (67 results)

All 2024 2023 2022 2021

All Journal Article (16 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 11 results,  Open Access: 13 results) Presentation (50 results) (of which Int'l Joint Research: 9 results,  Invited: 15 results) Book (1 results)

  • [Journal Article] Development of lung tissue models and their applications2023

    • Author(s)
      Petpiroon Nalinrat、Netkueakul Woranan、Sukrak Kanokwan、Wang Chen、Liang Yin、Wang Mengxue、Liu Yun、Li Qiang、Kamran Rumaisa、Naruse Keiji、Aueviriyavit Sasitorn、Takahashi Ken
    • Journal Title

      Life Sciences

      Volume: 334 Pages: 122208-122208

    • DOI

      10.1016/j.lfs.2023.122208

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stretch‐induced reactive oxygen species contribute to the Frank-Starling mechanism2023

    • Author(s)
      Kaihara Keiko、Kai Hiroaki、Chiba Yumiko、Naruse Keiji、Iribe Gentaro
    • Journal Title

      The Journal of Physiology

      Volume: - Issue: 18 Pages: 1-16

    • DOI

      10.1113/jp284283

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Compounding deep sea physical impacts on marine microbial motility2023

    • Author(s)
      Mullane KK., Nishiyama M., Kurihara T., Bartlett DH.
    • Journal Title

      Frontiers in Marine Science

      Volume: 10 Pages: 1-15

    • DOI

      10.3389/fmars.2023.1181062

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 高圧力顕微鏡による心筋細胞の収縮イメージング2023

    • Author(s)
      西山雅祥, 山口陽平, 金子智之, 森松賢順
    • Journal Title

      細胞

      Volume: 55 Pages: 36-38

    • Related Report
      2023 Annual Research Report
  • [Journal Article] SGLT2阻害薬の心筋機械的負荷誘発性酸化ストレス抑制効果2023

    • Author(s)
      千葉弓子、入部玄太郎
    • Journal Title

      細胞

      Volume: 733(55) Pages: 58-60

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Effect of mechanical stretching stimulation on maturation of human iPS cell-derived cardiomyocytes co-cultured with human gingival fibroblasts2023

    • Author(s)
      Wang Mengxue、Idei Harumi、Wang Chen、Liang Yin、Liu Yun、Matsuda Yusuke、Takahashi Ken、Kamioka Hiroshi、Naruse Keiji
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2023.12.15.567696

    • Related Report
      2023 Annual Research Report
    • Open Access
  • [Journal Article] Development of a human heart-on-a-chip model using induced pluripotent stem cells, fibroblasts and endothelial cells2023

    • Author(s)
      Liu Yun、Kamran Rumaisa、Han Xiaoxia、Wang Mengxue、Li Qiang、Lai Daoyue、Naruse Keiji、Takahashi Ken
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2023.12.06.569751

    • Related Report
      2023 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] High hydrostatic pressure induces slow contraction in mouse cardiomyocytes2023

    • Author(s)
      Yamaguchi Yohei、Nishiyama Masayoshi、Kai Hiroaki、Kaneko Toshiyuki、Kaihara Keiko、Iribe Gentaro、Takai Akira、Naruse Keiji、Morimatsu Masatoshi
    • Journal Title

      Biophysical Journal

      Volume: 122 Issue: 1 Pages: 267-267

    • DOI

      10.1016/j.bpj.2022.11.2940

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High hydrostatic pressure induces slow contraction in mouse cardiomyocytes2022

    • Author(s)
      Yamaguchi Yohei、Nishiyama Masayoshi、Kai Hiroaki、Kaneko Toshiyuki、Kaihara Keiko、Iribe Gentaro、Takai Akira、Naruse Keiji、Morimatsu Masatoshi
    • Journal Title

      Biophysical Journal

      Volume: 121 Issue: 17 Pages: 3286-3294

    • DOI

      10.1016/j.bpj.2022.07.016

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Live imaging of nitric oxide release in vascular endothelial cells in response to mechanical stimuli on an organ chip2022

    • Author(s)
      Takahashi K、Liu Y、Wang M、Liang Y、Naruse K
    • Journal Title

      European Heart Journal

      Volume: 43 Issue: Supplement_2

    • DOI

      10.1093/eurheartj/ehac544.3027

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional analysis of a kidney-on-a-chip using human renal proximal tubular epithelial cells and human umbilical vein endothelial cells2022

    • Author(s)
      Yin Liang, Mengxue Wang, Yun Liu, Keiji Naruse, Ken Takahashi
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 72(S1) Pages: 146-146

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Role of the TRPM4 channel in mitochondrial function, calcium release, and ROS generation in oxidative stress2021

    • Author(s)
      Wang Chen、Chen Jian、Wang Mengxue、Naruse Keiji、Takahashi Ken
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 566 Pages: 190-196

    • DOI

      10.1016/j.bbrc.2021.03.077

    • NAID

      120007099346

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRPV2 is involved in induction of lubricin and suppression of ectopic endochondral ossification in articular joints2021

    • Author(s)
      Nakamoto Hideki、Katanosaka Yuki、Chijimatsu Ryota、Mori Daisuke、Xuan Fengjun、Yano Fumiko、Omata Yasunori、Maenohara Yuji、Murahashi Yasutaka、Kawaguchi Kohei、Yamagami Ryota、Inui Hiroshi、Taketomi Shuji、Taniguchi Yuki、Kanagawa Motoi、Naruse Keiji、Tanaka Sakae、Saito Taku
    • Journal Title

      Arthritis & Rheumatology

      Volume: - Issue: 8 Pages: 1441-1450

    • DOI

      10.1002/art.41684

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Production of TRPM4 knockout cell line using rat cardiomyocyte H9c22021

    • Author(s)
      Wang C, Maeda M, Chen J, Wang M, Naruse K, Takahashi K
    • Journal Title

      MethodsX

      Volume: 8 Pages: 101404-101404

    • NAID

      120007168218

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Mechanisms of the Development of Atherosclerosis in Prediabetes2021

    • Author(s)
      Liang Yin、Wang Mengxue、Wang Chen、Liu Yun、Naruse Keiji、Takahashi Ken
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 8 Pages: 4108-4108

    • DOI

      10.3390/ijms22084108

    • NAID

      120007034439

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Systematic understanding of pathophysiological mechanisms of oxidative stress-related conditions-diabetes mellitus, cardiovascular diseases, and ischemia-reperfusion injury.2021

    • Author(s)
      Wang M, Liu Y, Liang Y, Naruse K, Takahashi K
    • Journal Title

      Front Cardiovasc Med

      Volume: 8 Pages: 649785-649785

    • NAID

      120007037390

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] マイクロ流体チップを用いた心臓機能の再構築2024

    • Author(s)
      王 夢雪、劉 云、カムラン ルマイサ、韓 暁霞、成瀬恵治、高橋 賢
    • Organizer
      第101回日本生理学会大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 新生児マウス心筋細胞のCa2+ハンドリングの成熟におけるTRPV2の役割2024

    • Author(s)
      董 玉冰、王 国昊、Chen Yanzhu、片野坂公明、成瀬恵治、片野坂友紀
    • Organizer
      第101回日本生理学会大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 筋肥大における衛星細胞TRPV2の役割2024

    • Author(s)
      陳 彦竹、董 玉冰、片野坂公明、 成瀬恵治、片野坂友紀
    • Organizer
      第101回日本生理学会大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 先天性心疾患の治療における生理学的評価の役割の重要性2024

    • Author(s)
      小谷恭弘、小松弘明、 貝原恵子、成瀬恵治、 入部玄太郎、笠原 真悟
    • Organizer
      第101回日本生理学会大会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] メカノメディスン2024

    • Author(s)
      成瀬恵治
    • Organizer
      岡山県医師会学術奨励賞受賞講演並びに日本医師会生涯教育講座
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Viewing the swimming motion of a unicellular organism in extreme conditions.2024

    • Author(s)
      Nishiyama M
    • Organizer
      Exploration and Application of Extracellular Membrane Vesicle-Producing Bacteria as a Basic Technology for Aquaculture Augmentation
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 静水圧で躍動する分子マシナリ2024

    • Author(s)
      西山雅祥
    • Organizer
      第1回関西生物物理学研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 高脂肪食負荷により心筋細胞の急性伸展誘発性ROS産生は増加する2024

    • Author(s)
      千葉弓子、入部玄太郎
    • Organizer
      第101回日本生理学会大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 新たな蛍光顕微鏡を用いた過重力下のオルガネラ挙動の解明2023

    • Author(s)
      貝原 恵子、松浦 宏治、成瀬 恵治
    • Organizer
      第62回日本生体医工学会大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] マウス心筋細胞の力学特性に対するTRPC6ノックアウトの影響2023

    • Author(s)
      山口陽平、金子智之、成瀬恵治、大矢 進、入部玄太郎
    • Organizer
      令和5年度生理学研究所研究会「新しい扉を拓くTRPチャネル」
    • Related Report
      2023 Annual Research Report
  • [Presentation] Microfluidic culture of highly barrier-functional endothelial cells: mimicking in vivo vascular environment for organ chip applications2023

    • Author(s)
      Han X, Liu Y, Wang M, Kamran R, LiQ, LaiD, Naruse K, Takahashi K
    • Organizer
      生体医工学シンポジウム2023
    • Related Report
      2023 Annual Research Report
  • [Presentation] Hydrostatic pressure stimuli increase intracellular calcium concentration2023

    • Author(s)
      Morimatsu M, Gao Z, Naruse K
    • Organizer
      第61回日本生物物理学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 臓器チップ上の血管内皮細胞におけるメカニカルストレス誘発性一酸化窒素放出のライブイメージング系の開発2023

    • Author(s)
      李 強、劉 雲、王 夢雪、Rumaisa Kamran、成瀬恵治、高橋賢
    • Organizer
      第17回日本臨床ストレス応答学会大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] メカノメディスン:深海から宇宙まで2023

    • Author(s)
      成瀬恵治
    • Organizer
      第30回日本未病学会学術総会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] メカノメディスン2023

    • Author(s)
      成瀬恵治
    • Organizer
      令和5年度生理学研究所研究会「新しい扉を拓くTRPチャネル」
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Mechanomedicine2023

    • Author(s)
      Naruse K
    • Organizer
      Second China-Japan Symposium on Medical Exchange
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Depressurization microscopy2023

    • Author(s)
      Nishiyama M
    • Organizer
      第61回日本生物物理学会年会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] SGLT2阻害薬は心臓の機械的負荷由来の酸化ストレスを抑制する2023

    • Author(s)
      千葉弓子、入部玄太郎
    • Organizer
      第44回日本循環制御医学会総会・学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Facilitated differentiation of induced pluripotent stem cells into cardiomyocytes in a microfluidic chip2023

    • Author(s)
      Kamran R, Liu Y, Li Q, Naruse K, Takahashi K
    • Organizer
      日本理学会第100回記念大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Development of a lung fibrosis model using lung epithelial cells, fibroblasts, and vascular endothelial cells2023

    • Author(s)
      Li Q, Liu Y, Wang M, LiangnY,Naruse K, Takahashi K
    • Organizer
      日本理学会第100回記念大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] TRPV2 of muscle satellite cells is crucial for the muscle regeneration2023

    • Author(s)
      陳 彦竹、DONG YUBING、片野坂公明、深田宗一朗、成瀬恵治、片野坂友紀
    • Organizer
      日本理学会第100回記念大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 心臓の構造的・機能的成熟ににおける TRPV2の役割2023

    • Author(s)
      DONG YUBING、氏 嘉洋、CHEN YANZHU、片野坂公明、成瀬恵治、片野坂友紀
    • Organizer
      日本理学会第100回記念大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ヒト単離心筋細胞における長さ張力関係を用いた力学機能評価2023

    • Author(s)
      小松弘明、小谷恭弘、貝原恵子、成瀬恵治、笠原真悟、入部玄太郎
    • Organizer
      日本理学会第100回記念大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] メカノメディスン2022

    • Author(s)
      成瀬恵治
    • Organizer
      Brainstorming 2022
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] メカノメディスン:基礎から臨床まで2022

    • Author(s)
      成瀬恵治
    • Organizer
      第48回佐島シンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Mechanical stretch facilitates cardiomyocyte differentiation of human-induced pluripotent stem cells co-cultured with human gingival fibroblasts Invited2022

    • Author(s)
      Takahashi K, Idei H, Wang M, Matsuda Y, Kamioka H, Naruse K
    • Organizer
      9th World Congress of Biomechanics
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The role of TRPV2 in pressure overload-induced pathological cardiac remodeling2022

    • Author(s)
      Katanosaka Y, Yubing D, Yanzhu C, Naruse N
    • Organizer
      9th World Congress of Biomechanics
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TRPV2 is essential for the maturation and hypertrophic responses of cardiomyocytes via promotion of sarcoplasmic reticulum Ca2+ ATPase (SERCA)2022

    • Author(s)
      Yubing D, Yanzhu C, Naruse N, Katanosaka Y
    • Organizer
      9th World Congress of Biomechanics
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanomedicine and Piezobiology2022

    • Author(s)
      Naruse K
    • Organizer
      11th International Conference on High Pressure Bioscience and Biotechnology (HPBB2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Human heart-on-a-chip that responds to noradrenaline and mechanical stimulus2022

    • Author(s)
      Takahashi K, Liu Y, Wang M, Kamran R, Naruse K
    • Organizer
      Cell Symposium: Advances in Therapeutic Applications of Stem Cells
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Live imaging of nitric oxide release in vascular endothelial cells in response to mechanical stimuli on an organ chip2022

    • Author(s)
      Takahashi K, Liu Y, Wang M, Liang Y, Naruse K
    • Organizer
      ESC Congress 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a lung fibrosis model on transwells2022

    • Author(s)
      李 強、劉 雲、王 夢雪、梁 茵、 成瀬恵治、高橋 賢
    • Organizer
      第74回 日本生理学会中国四国地方会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ヒト単離心筋細胞における長さ張力関係を用いた力学機能評価2022

    • Author(s)
      小松弘明、小谷恭弘、貝原恵子、成瀬恵治、笠原真悟、入部玄太郎
    • Organizer
      第45回日本生体医工学会中国四国支部大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 重力が老化に及ぼす影響2022

    • Author(s)
      高橋 賢、成瀬恵治
    • Organizer
      第61回日本生体医工学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 高圧刺激下での細胞動態の可視化2022

    • Author(s)
      森松賢順、成瀬恵治
    • Organizer
      第61回日本生体医工学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] High Hydrostatic Pressure induces slow Contraction in mouse Cardiomyocytes2022

    • Author(s)
      Yamaguchi Y, Nishiyama M, Kai H, Kaneko T, Kaihara K, Iribe G, Takai A, Naruse K, Morimatsu M
    • Organizer
      第60回日本生物物理学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 過重力下における細胞内小器官観測可能な新たな蛍光遠心顕微鏡の開発2022

    • Author(s)
      貝原恵子、成瀬恵治
    • Organizer
      第60回日本生物物理学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] SGLT2阻害薬はSMIT1を介して心筋の急性伸展刺激誘発性ROS産生を抑制する2022

    • Author(s)
      千葉弓子、金井秀太、板倉正道、入部玄太郎
    • Organizer
      第102回日本生理学会北海道地方会
    • Related Report
      2022 Annual Research Report
  • [Presentation] メカノメディスン2022

    • Author(s)
      成瀬恵治
    • Organizer
      第21回日本再生医療学会総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] メカノメディスン2022

    • Author(s)
      成瀬恵治
    • Organizer
      生理学研究所 : 細胞の局所コミュニティ研究会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] メカノメディスンーメカノバイオロジーから医療へー2022

    • Author(s)
      成瀬恵治
    • Organizer
      Liaison Tsunaguミーティング
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Role of NOX4-TRPV1 interaction on single cell mechanics in mouse ventricular cardiomyocytes.2022

    • Author(s)
      Kaihara K, Naruse K, Iribe G
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Functional analysis of a kidney-on-a-chip using human renal proximaltubular epithelial cells and human umbilical vein endothelial cells.2022

    • Author(s)
      Takahashi K, Liang Y,Wang M,Liu Y, Naruse K
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] TRPV2 is Involved in the Hypertrophic Response of Skeletal Muscle Induced by Mechanical Overload.2021

    • Author(s)
      Katanosaka Y, Chen Y, Dong Y, Shibuya M, Naruse K
    • Organizer
      The 3rd International Yangtze River Delta Symposium on Mechanobiology & the 9th Chinese National Symposium of Medical Biophysics
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of a human heart-on-a-chip model using induced pluripotent stem cells, fibroblasts and endothelial cells.2021

    • Author(s)
      Liu Y, Wang M, Liang Y, Naruse K, Takahashi K
    • Organizer
      ESC Congress 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a model of human heart using organ-on-a-chip2021

    • Author(s)
      Takahashi K,Liu Y,Wang M,Liang Y, Naruse K
    • Organizer
      第60回日本生体医工学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] メカノメディスン:メカノバイオロジーと宇宙医学2021

    • Author(s)
      成瀬恵治
    • Organizer
      第67回日本宇宙航空環境医学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] SMAD 3 Signaling Pathway in Chondrocytes under High Hydrostatic Pressure2021

    • Author(s)
      Xinxuan Li, Keiji Naruse, Masatoshi Morimatsu
    • Organizer
      Materials, Mimics, and Microfluidics: Engineering Tools for Mechanobiology (MBI 3M)
    • Related Report
      2021 Annual Research Report
  • [Presentation] 高圧刺激下での軟骨細胞の動態計測2021

    • Author(s)
      森松 賢順,Li Xinxuan,西山 雅祥, 成瀬 恵治
    • Organizer
      第44回日本生体医工学会中国四国支部大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] High hydrostatic pressure regulate TGF-β signaling pathway in human chondrocytes2021

    • Author(s)
      M. Morimatsu, X. Li, M.Nishiyama, K.Naruse
    • Organizer
      第59回日本生物物理学会年会
    • Related Report
      2021 Annual Research Report
  • [Book] 1-5-5: 極限環境で復活する鞭毛運動, 極限環境微生物の先端科学と社会実装最前線(伊藤政博 他編著)2023

    • Author(s)
      西山雅祥, 八木俊樹
    • Total Pages
      11
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2023 Annual Research Report

URL: 

Published: 2021-04-28   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi